A5102903211- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Regulation of Appetite and Obesity
- Neurofibromatosis and Schwannoma Cases
- Olfactory and Sensory Function Studies
- Multiple Myeloma Research and Treatments
- Advanced X-ray and CT Imaging
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Advanced Radiotherapy Techniques
- Neurobiology of Language and Bilingualism
- Diet and metabolism studies
- Neural dynamics and brain function
- Hedgehog Signaling Pathway Studies
- Ophthalmology and Eye Disorders
- Memory and Neural Mechanisms
- Radiation Dose and Imaging
Beijing Tian Tan Hospital
2018-2024
Capital Medical University
2018-2024
Shanghai Optical Instrument Research Institute
2014
The human brain has an extraordinary ability to functionally change or reorganize its structure in response disease. aim of this study is assess the structural and functional plasticity contralesional medial temporal lobe (MTL) patients with unilateral MTL glioma.Sixty-eight glioma (left glioma, n = 33; right 35) 40 healthy controls were recruited scanned 3D T1 MRI rest-fMRI. We explored using voxel-based morphometry (VBM) assessed memory networks hemisphere resting-state connectivity...
Craniopharyngioma (CP) is a histologically benign tumor with high mortality and morbidity. Although surgical treatment essential in managing CP, the best approach debated. A retrospective cohort of 117 patients adult-onset CP (AOCP) treated between 2018 2020 Beijing Tiantan Hospital was identified examined. The effects traditional craniotomy (TC) endoscopic endonasal transsphenoidal surgery (EETS) on extent resection, hypothalamic involvement (HI), postoperative endocrine function, weight...
Abstract Background Craniopharyngioma (CP) is a rare malformational tumor characterized by high rates of recurrence and morbid obesity. However, the role inflammatory mediators in obesity prognosis patients with CP remains unknown. Therefore, present study aimed to analyze associations weight-related outcomes CP. Methods A total 130 consecutive were included this study. The expression levels seven plasma leptin concentration investigated. Clinical parameters, weight changes, new-onset...
Growth hormone (GH) and its anabolic mediator, insulin-like growth factor-1 (IGF-1), have a critical role in the central nervous system. However, their detailed roles adult human brain are not clear. In this study, structural MRIs of 48 patients with GH-secreting pituitary adenoma (GH-PA), sex- age-matched clinical Non-Functional (NonFun-PA) healthy controls (HCs) were assessed using voxel-based morphometry (VBM) region-based (RBM). Correlation analyses helped determine relationships between...
Prior investigations of language functions have focused on the response profiles particular brain regions. However, specialized and static view processing does not explain numerous observations functional recovery following surgery. To investigate dynamic alterations connectivity (FC) within network (LN) in glioma patients, we explored a new flexible model based neuroscientific hypothesis core-periphery organization LN. Group-level LN mapping was determined from 109 patients forty-two...
Emerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed alterations in are present gliomas, meningiomas, and pituitary neuroendocrine tumors (Pit-NETs). However, correlation between craniopharyngioma (CP), a rare embryonic malformation tumor sellar region, not previously mentioned. Consequently, this study aimed to investigate composition metabolic patterns CP patients, goal of identifying potential therapeutic approaches.
Craniopharyngioma (CP) is a benign tumor with high rate of obesity and frequent recurrence. Moreover, the role leptin/leptin receptors axis in prognosis CP still unknown. Plasma leptin concentration mRNA expression were assessed patients CP. association between axis, weight-related outcomes, progression-free survival (PFS) explored patients. Leptin overexpressed tissue compared to normal brain (p < 0.05); healthy controls, was elevated or without matched age, sex, body mass index (BMI)...
Background and Objective: Large suprasellar tumors often compress the optic chiasm give rise to visual impairment. Most patients have significantly improved function at 1 4 months after chiasmal decompression surgery, only a few individuals regain normal vision week surgery. How recovery of in these affects cortex is not fully understood. In this study, we aimed investigate alterations brain functional connectivity (FC) tumor with improvement using resting-state magnetic resonance imaging...
Hypothalamic nuclei in the preoptic and anterior hypothalamic region (POAH) are critically involved thermoregulation neuroendocrine regulation can be displaced by craniopharyngiomas (CPs). We aimed to locate POAH visualizing through task-related functional magnetic resonance imaging (fMRI) guide hypothalamus protection intraoperatively. Nine adult healthy volunteers (HVs) thirty-two primary CP patients underwent fMRI for localization warm (60° C) cold (0° cutaneous thermoreceptor...
The growth hormone (GH) and insulin-like-growth factor 1 (IGF-1) axis has long been recognized for its critical role in brain growth, development. This study was designed to investigate microstructural pathology the cortex white matter hormone-secreting pituitary adenoma, which characterized by excessive secretion of GH IGF-1. 29 patients with adenoma (acromegaly) 31 non-functional as controls were recruited assessed using neuropsychological test, surface-based morphometry, T1/T2-weighted...
Obesity presents a significant challenge in managing patients with craniopharyngioma (CP). Cyst fluid (CF), rich inflammatory mediators, is implicated CP-related obesity, though the precise mechanism remains unclear. This study investigated impact of CF or C-X-C motif chemokine ligand-1 (CXCL1) injections on body weight, Lee index, plasma lipid profiles, hepatic accumulation, leptin levels, NF-κB pathway, suppressor cytokine signaling 3 (SOCS3) expression, and sensitivity rats....
To investigate the clinical and pathological factors associated with preoperative hypothalamus invasion postoperative outcomes of adamantinomatous craniopharyngiomas (ACPs) after expanded endonasal approach (EEA) resection.Ninety-three specimens ACPs, consisting 71 primary 22 recurrent tumors, were investigated for expression TGF-β1, SMAD2, SMAD3, β-catenin by immunohistochemistry staining. The information relevant patients, including extent resection, invasion, endocrinopathy,...
<title>Abstract</title> Background Emerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed alterations in are present gliomas, meningiomas, and pituitary neuroendocrine tumors (Pit-NETs). However, correlation between craniopharyngioma (CP), a rare embryonic malformation tumor sellar region, not previously mentioned. Consequently, this study aimed to investigate composition metabolic patterns CP patients, goal of...
<title>Abstract</title> Background: Craniopharyngioma (CP) is a rare malformational tumor characterized by high rates of recurrence and morbid obesity. However, the role inflammatory mediators in obesity prognosis patients with CP remains unknown. Therefore, present study aimed to analyze associations weight-related outcomes CP. Methods: A total 130 consecutive were included this study. The expression levels seven plasma leptin concentration investigated. Clinical parameters, weight changes,...
Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine multi-modal neuroimaging histological characteristics explore potential HI-related decline. 45 primary ACPs (invasive, 23; noninvasive, 22) 52 healthy control subjects (HCs) were admitted cross-sectional study. No significant difference...
Owing to the close vicinity of optic chiasma, visual dysfunction is known as one most common surgical indications and postoperative complications in adult patients with craniopharyngiomas, probably leading poor quality life. Historically, very few consistent predictive factors associated outcome are identified, which may not be helpful for patient counseling preoperative decision making. Recently, optical coherence tomography (OCT) serving a novel high-resolution imaging technique can assess...
Background:Malignant high-grade gliomas are characterized by infiltration and destruction of surrounding brain tissue. Alterations contrahemispheric structure their roles in offer prognostically valuable information have not been investigated gliomas. Methods: 153 patients with unilateral glioma (low-grade, n=77; high-grade, n=76) 115 healthy controls were recruited scanned 3D T1 imaging. Gray matter (GM), white matter, cerebrospinal fluid volume contrahemisphere examined. Correlation...