A5045753153- RNA modifications and cancer
- Nicotinic Acetylcholine Receptors Study
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Head and Neck Surgical Oncology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- Hippo pathway signaling and YAP/TAZ
Beijing Tian Tan Hospital
2022-2025
Capital Medical University
2022-2025
Jinan Central Hospital
2016-2025
Shandong University
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Shandong First Medical University
2020-2025
Weifang Medical University
2024-2025
Peking University First Hospital
2024-2025
Peking University
2024-2025
Lanzhou University
2015-2023
Gastric signet ring cell carcinoma (GSRC) is a special subtype of gastric cancer (GC) associated with poor prognosis, but an in-depth and systematic study GSRC lacking. Here, we perform single-cell RNA sequencing to assess GC samples. We identify (SRCC) cells. Microseminoprotein-beta (MSMB) can be used as marker gene guide the identification moderately/poorly differentiated adenocarcinoma (SRCC). The upregulated differentially expressed genes in SRCC cells are mainly enriched abnormally...
Ferroptosis holds great potential as a therapeutic approach for gastric cancer (GC), prevalent and deadly malignant tumor associated with high rates of incidence mortality. Myricetin, well-known its multifaceted biomedical attributes, particularly anticancer properties, has yet to be thoroughly investigated regarding involvement in ferroptosis. The aim this research was elucidate the impact myricetin on ferroptosis GC progression. present study observed that could trigger cells by enhancing...
This study aims to elucidate the primary signaling communication among papillary craniopharyngioma (PCP) tumor cells. Five samples of PCP were utilized for single-cell RNA sequencing. The most relevant ligand and receptor interactions different cells calculated using CellChat package in R software. Bulk sequencing 11 five normal controls was used investigate pair detected by Fibroblasts not found ACP, whereas they PCP. InferCNV revealed high CNV scores clusters epithelial fibroblasts immune...
Immune inhibitory receptors play an important role in organ transplantation, autoimmune diseases and cancers. Immunoglobulin-like transcript (ILT)2 ILT3 belong to the of ILT family, which have been reported regulate a broad range cellular functions involved immune response. They contain immunoreceptor tyrosine-based motifs (ITIMs), are related regulation. Although studied dendritic cells (DCs), T cells, NK other cell types, expression clinical significance ILT2 gastric cancer yet be...
This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats.A total 45 rats were randomly divided into control (n = 15, normal diet) groups 30, fed for 16 weeks. Body weight organ indexes determined after sacrifice. Indicators reproductive function, including sperm count, motility, apoptosis spermatogenic cells, oxidative stress levels, measured. Serum metabolic parameters hormones also assayed.Compared with...
Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted therapies and immunotherapies yielded limited clinical benefits for cancer patients. It hoped that delineating molecular mechanisms underlying drug resistance in may provide therapeutic options. Using acquired gemcitabine cell lines, we revealed an...
Helicobacter pylori (H. pylori) infection causes aberrant DNA methylation and contributes to the risk of gastric cancer (GC). Guanine nucleotide-binding protein subunit beta-4 (GNB4) is involved in various tumorigenic processes. We found an level GNB4 H. pylori-induced GC our previous bioinformatic analysis; however, its expression underlying molecular mechanisms are poorly understood.The expression, signaling pathways, clinical significance were analyzed a local cohort 107 patients with...
Gastrointestinal (GI) cancer is one of the most severe types cancer, with a significant impact on human health worldwide. Due to urgent demand for more effective therapeutic strategies against GI cancers, novel research metal ions treating cancers has attracted increasing attention. Currently, accumulating relationship between and therapy, several have been discovered induce cell death. In particular, three modes death, including ferroptosis, cuproptosis, calcicoptosis, become focal points...
Abstract Background Suicidal ideation (SI) is very common in patients with major depressive disorder (MDD). However, its neural mechanisms remain unclear. The anterior cingulate cortex (ACC) region may be associated SI MDD patients. This study aimed to elucidate the of by analyzing changes gray matter volume (GMV) brain structures ACC region, which has not been adequately studied date. Methods According REST-meta-MDD project, this subjects consisted 235 healthy controls and 246 patients,...
Breast cancer remains the most prevalent malignancy and leading cause of cancer-related mortality among women worldwide. The primary factors contributing to deterioration death patients with breast are metastasis, recurrence, drug resistance. These phenomena closely related presence stem cells; however, exact mechanisms regulating stemness remain be elucidated. Rack1 (Receptor for Activated C Kinase 1), a well-known versatile scaffold protein, has been implicated in tumorigenesis progression...
Mesenchymal stem cells (MSCs) can differentiate into chondroblasts, adipocytes, or osteoblasts under appropriate stimulation. Mechano-growth factor (MGF) reportedly displays a neuroprotective effect in cerebral regions that were exposed to ischemia and is expressed stromal of the eutopic endometrium glandular ectopic endometrium.This study sought understand potential involvement phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) MGF-induced growth rabbit MSCs (rMSCs). We applied...
Abstract Gastric cancer (GC) is a lethal disease, and among its variety of etiological factors, Helicobacter pylori ( H. ) infection the strongest risk factor. However, genetic molecular mechanisms underlying ‐related GC need further elucidation. We investigated competing endogenous RNA (ceRNA) network differences between (+) (−) GC. The long noncoding (lncRNA), microRNA (miRNA), messenger (mRNA) expression data from 32 adjacent noncancerous samples 18 141 stomach adenocarcinoma were...
Nicotine and nicotinic acetylcholine receptors (nAChRs) are considered to be involved in lung cancer risk, onset progression, but their precise physiological roles these contexts remain unclear. Our previous studies suggested that α5-nAChR mediates nicotine-induced cell proliferation, migration invasion vitro. In this study, we aimed determine the role of development progression non-small (NSCLC). microarray results reveal knockdown CHRNA5 gene encoding significantly modulates key pathways...
Abstract Background Immunotherapy has proven to be an emerging treatment for non-small-cell lung cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD-L1) expression and better responses PD-1/PD-L1 inhibitors than nonsmokers. Genome-wide association studies that the CHRNΑ5 encoding α5-nicotinic acetylcholine receptor (α5-nAChR) is especially relevant nicotine dependence. Jab1 a key regulatory factor promotes stabilization of PD-L1. Our previous study...
GLI1, a key transcription factor of the Hedgehog (Hh) signaling pathway, plays an important role in development cancer. However, function and mechanisms by which GLI1 regulates gene are not fully understood gastric cancer (GC). Here, we found that induced proliferation metastasis GC cells, accompanied transcriptional upregulation INHBA. This increased INHBA expression exerted promoting activity on Smads then transcriptionally activated expression. Notably, our results demonstrate disrupting...
Abstract Background Gastric cancer is a leading causes of cancer-related deaths ,but the underlying molecular mechanisms its progression are largely unknown. Differentiated embryonic chondrocyte-expressed gene 1 (DEC1), an important transcription factor involved in tumors and has recently been identified to be strongly inducible by hypoxia. Little known about contribution DEC1 intracellular hypoxia proliferation signaling events gastric cancer. Methods Immunohistochemistry was used detect...