A5023200291- Heavy Metal Exposure and Toxicity
- Healthcare professionals’ stress and burnout
- Health disparities and outcomes
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Microbial Metabolism and Applications
- Sleep and related disorders
- Health and Well-being Studies
- Job Satisfaction and Organizational Behavior
- Geoscience and Mining Technology
- Urban Transport and Accessibility
- Medical Education and Admissions
- Air Quality and Health Impacts
- Heavy metals in environment
- Pharmacological Effects of Natural Compounds
- Trace Elements in Health
- Health and Wellbeing Research
- Noise Effects and Management
- Global Health Care Issues
- Clostridium difficile and Clostridium perfringens research
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Fermentation and Sensory Analysis
- Aluminum toxicity and tolerance in plants and animals
- Aging and Gerontology Research
Anhui Medical University
2012-2025
Southern Medical University
2022-2025
Dongguan People’s Hospital
2023-2025
Zunyi Medical University
2025
North Sichuan Medical University
2023-2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
First Affiliated Hospital of Chengdu Medical College
2024
Fuzhou University
2021-2023
Institute of Food Science and Technology
2021-2023
Affiliated Hospital of North Sichuan Medical College
2021-2022
The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism...
Abnormal tumor metabolism creates a complex immune microenvironment that plays dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is insensitive to checkpoint blockade (ICB) therapy because insufficient cytotoxic T lymphocyte (CTL) infiltration and hyper-lactic acid-suppressive caused by abnormal glycolysis. Herein, we propose an amplified strategy based on lactic acid regulation reprogram immunosuppressive (ITM) combine it with ICB achieve enhanced antitumor...
The evidence about the effect of essential trace element (ETE) mixture on cognitive function amongst older adults is limited. This study aims to evaluate associations single ETEs and ETE with using a representative sample community-dwelling in China.A total 3814 were included study. Urinary concentrations selenium (Se), vanadium (V), cobalt (Co), strontium (Sr), molybdenum (Mo) detected by inductively coupled plasma mass spectrometry. Cognitive was assessed Chinese version Mini-Mental State...
Objective: The gut microbiota and its metabolites are important for host physiological homeostasis, while dysbiosis is related to diseases including the development of cancers such as colorectal cancer (CRC). In this study, we characterized relationship an altered microbiome with fecal metabolome in CRC patients comparison volunteers having a normal mucous membrane (NC). Methods: richness composition samples 30 36 NC controls were analyzed through 16S rRNA gene sequencing, was determined by...
The hypopermeability and hypoxia in the tumor milieu are important factors that limit multiple treatments. Herein, reactive oxygen species (ROS)-triggered self-assembled nanoparticles (RP-NPs) was constructed. natural small molecule Rhein (Rh) encapsulated into RP-NPs as a sonosensitizer highly accumulated at site. Then tissue-permeable ultrasound (US) irradiation induced apoptosis of cells through excitation Rh acoustic cavitation, which prompted rapid production large amounts ROS hypoxic...
Abstract Background Job burnout is a prevalent and emerging challenge in the primary medical system, causing mass turnover, especially of staff. Little attention has been paid to different dimensions job (emotional exhaustion, personality disintegration, reduced sense achievement), which may hinder efforts tackle high turnover intention among From perspective conservation resources theory, social support psychological capital are basic with potential diminish thus lower intention. However,...
Ferroptosis combined with photodynamic therapy (PDT) has emerged as a powerful approach to induce cancer cell death by producing and accumulating lethal reactive oxygen species (ROS) in the tumor microenvironment (TME). Despite its efficacy safety, challenges persist delivering multiple drugs site for enhanced antitumor improved tissue targeting. Hence, we designed method of inducing ferroptosis through laser-mediated human homologation-specific efficient activation, which is also higher...
Abstract RelA, also known as nuclear factor kappa B p65, plays a crucial role in the pathogenesis of various liver diseases. However, specific RelA hepatocytes during progression metabolic dysfunction-associated steatotic disease (MASLD) is not well understood. This study explored relationship between impaired signaling and lipid metabolism disorders hepatocytes, how they synergistically contribute to advancement MASLD. We assessed changes, regulatory relationships, impacts remodeling on...
The combined effects of physical activity (PA) and nitrogen dioxide (NO2) on fasting plasma glucose (FPG) levels have rarely been studied. This study aimed to examine whether long-term exposure NO2 attenuates the association between PA FPG in non-diabetic older adults. A total 2600 elderly Chinese adults were included this cross-sectional study. data collected using International Physical Activity Questionnaire (IPAQ). Space-Time Extra-Trees model was utilized estimate annual concentration...
The shortage of primary medical staff is an important issue in the management health human resources, and it also a problem that all countries world need to face together. Since 2009, China has implemented new series system reforms loss have been alleviated accordingly. However, large population difficult distribute resources evenly across regions. This study aimed explore current status turnover intention its relationship with psychological capital, social support, job burnout, as well how...
As one of the quintessential representatives Chinese rice wine, Hongqu wine is brewed with glutinous as main raw material and (Gutian Qu or Wuyi Qu) fermentation starter. The present study aimed to investigate impact on volatile compositions microbial communities in traditional production Gutian (GT) (WY). Through OPLS-DA analysis, 3-methylbutan-1-ol, isobutanol, ethyl lactate, acetate, octanoic acid, diethyl succinate, phenylethyl alcohol, hexanoic acid n-decanoic were identified...
Monascus-fermented red mold rice (RMR) has excellent physiological efficacy on lipid metabolism and liver function. This study investigated the ameliorative effects of monascuspiloin (MP) from RMR alcoholic injury in mice, further clarified its mechanism action. Results showed that MP intervention obviously ameliorated function mice with over-drinking. In addition, dietary reduced MDA levels increased CAT, SOD, GSH levels, thus alleviating oxidative stress induced by excessive drinking. 16S...
Abstract Aims Inflammatory bowel disease (IBD) is associated with F. nucleatum, and chronic stress can increase the risk of aggravation. However, whether norepinephrine (NE) enhance pathogenicity nucleatum to aggravate dextran sulfate sodium salt (DSS)-induced colitis unclear. Methods Transcriptome sequencing was used identify differentially expressed genes in bacteria treated NE. Affinity testing molecular docking were applied calculate predict binding NE Quorum sensing regulators C (QseC)....
Abstract Falls can cause serious health problems in the elderly. China is gradually entering a moderately aging society. In rural areas of China, elderly are at higher risk falling. This study aims to explore and analyze factors affecting fall people provide theoretical basis for reducing people. M County, Anhui Province, was selected as survey site by typical field sampling method, were research objects. A total 1187 investigated. Mann–Whitney U test Kruskal–Wallis H used univariate...
Purpose: We aimed to assess the current status of depressive symptoms and quality life (QoL) among rural elderly in central China (Anhui Province) explore their correlation associated factors for symptoms. Methods: A multi-stage random sampling method was used obtain 3349 participants (aged ≥60): 1206 poor 2143 non-poor. The 30-item Geriatric Depression Scale (GDS-30) five-dimensional European health scale (EQ-5D) were employed evaluate QoL, respectively. Results: prevalence 52.9%, that...
Background: The shortage of primary medical staff is a major problem in the management health human resources across many developing countries. By determining their preferences for various motivational and related factors, we examined correlation between staff's motivation preference levels turnover intention. This study aimed to further improve incentive mechanism provide reference healthcare managers formulate strategies team. Methods: A self-reported questionnaire survey was conducted...