A5101406784- Retinal Diseases and Treatments
- Ferroptosis and cancer prognosis
- Glaucoma and retinal disorders
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Retinal Imaging and Analysis
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Intestinal Malrotation and Obstruction Disorders
- RNA Interference and Gene Delivery
- Data-Driven Disease Surveillance
- Phenothiazines and Benzothiazines Synthesis and Activities
- Health disparities and outcomes
- Retinal and Optic Conditions
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Crystal structures of chemical compounds
- Epigenetics and DNA Methylation
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Child and Adolescent Psychosocial and Emotional Development
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Pandemic Impacts
- Metabolomics and Mass Spectrometry Studies
Jiangsu University
2014-2025
Affiliated Hospital of Jiangsu University
2014-2025
First Affiliated Hospital of Soochow University
2024-2025
Soochow University
2024-2025
Qiqihar Medical University
2021-2025
Fudan University
2019-2024
Anhui Medical University
2019-2024
Second Hospital of Anhui Medical University
2021-2024
China Medical University
2024
University of Hong Kong
2024
BackgroundThe outbreak of coronavirus disease 2019 (COVID-19) has posed stress on the health and well-being both Chinese people public worldwide.Global interest in this new issue largely reflects people' s attention to COVID-19 their willingness take precautionary actions.This study aimed examine global awareness using Google Trends.Methods Using Trends, we retrieved query data for terms "2019-nCoV + SARS-CoV-2 novel Corona Virus Disease 2019" between 31 st December 24 th February 2020 six...
Background: The outbreak of coronavirus disease 2019 (COVID-19) has posed stress on the health and well-being people worldwide. Global public interest in this new issue largely reflects people's attention to COVID-19 their willingness take precautionary actions. This study aimed examine global awareness using Google Trends.Methods: Using Trends, we retrieved query data for terms [2019-nCoV + SARS-CoV-2 novel Corona Virus Disease 2019] between 31th Dec 24th Feb 2020 six major English-speaking...
The pandemic of coronavirus disease 2019 (COVID-19) is spreading worldwide with an uncertain ultimate impact on every aspect human society. Recognizing the groups higher susceptibility and fatality are in urgent need.We retrieved total number confirmed incident death cases COVID-19 177 countries/territories from Center for Systems Science Engineering (CSSE) at Johns Hopkins University (JHU). Data age gender composition were collected United Nations Department Economic Social Affairs....
Thrombolytic agents have thus far yielded limited therapeutic benefits in the treatment of thrombotic disease due to their short half-life, low targeting ability, and association with serious adverse reactions, such as bleeding complications. Inspired by natural roles platelets during thrombus formation, we fabricated a platelet-based delivery system (NO@uPA/PLTs) comprising urokinase (uPA) arginine (Arg) for targeted thrombolysis inhibition re-embolism. The anchoring uPA platelet surface...
Abstract Background Although previous studies have found that parenting style significantly predicts emotional and behavioral problems (EBPs) among Chinese adolescents, the mechanism between different styles EBPs requires in-depth investigation. In our study, we aimed to investigate mediating effect of resilience, a positive psychological characteristic, adolescents. Methods this cross-sectional used multistage stratified cluster random sampling method collect data in Shenyang, Liaoning...
Photothermal therapy combined with chemotherapy has shown great promise in the treatment of cancer. In this synergistic system, a safe, stable, and efficient photothermal agent is desired. Herein, an effective agent, carbon quantum dots (CQDs), was initially synthesized then rationally constructed folic acid (FA)-targeted multifunctional nanoplatform by encapsulating CQDs anticancer drug doxorubicin (DOX) liposomes. Indocyanine green (ICG), near infrared (NIR) approved U.S. Food Drug...
Hepatocellular carcinoma(HCC) has a high mortality and morbidity rate seriously jeopardizes human life. Chemicals chemotherapeutic agents have been experiencing problems such as side effects drug resistance in the treatment of HCC, which cannot meet needs clinical treatment. Therefore, finding novel low-toxicity high-efficiency anti-hepatocellular carcinoma drugs exploring their mechanisms action become current to be solved HCC. Several studies reported anticancer inotodiol. This study...
Amiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated systemic and ocular complications. While keratopathy being the most prevalent, affecting 70–100% of long-term users, amiodarone-associated optic neuropathy (AAON), though rare (incidence: 0.36–2%), can induce diverse visual impairments, ranging from mild deficits to profound vision loss. Given that patients on amiodarone frequently possess risk factors vascular diseases, it essential...
Purpose: We aimed to assess the current status of depressive symptoms and quality life (QoL) among rural elderly in central China (Anhui Province) explore their correlation associated factors for symptoms. Methods: A multi-stage random sampling method was used obtain 3349 participants (aged ≥60): 1206 poor 2143 non-poor. The 30-item Geriatric Depression Scale (GDS-30) five-dimensional European health scale (EQ-5D) were employed evaluate QoL, respectively. Results: prevalence 52.9%, that...
Introduction Adolescent suicide is a prevalent issue globally, with various factors contributing to this phenomenon. This study aimed investigate these and their interrelationships better understand the causes of adolescent provide evidence for its prevention. Methods conducted among middle school students in Liaoning Province, China, from April May 2016, A cross-sectional survey was administered 1,028 aged 10–19, using instruments such as Behavior Questionnaire-Revised (SBQ-R), Children's...
Abstract Antagonizing vascular endothelial growth factor receptor 2 (VEGFR2) to block angiogenesis has been applied toward cancer therapy for its role in promoting and metastasis. However, most these clinical anticancer drugs have unexpected side effects. Development of novel VEGFR2 inhibitors with less toxicity remains an urgent need. In this study, we describe a novel, well-tolerated orally active inhibitor, YLT192, which inhibits tumor growth. YLT192 significantly inhibited kinase...
The global burden of digestive diseases has been rising in the last 30 years. rates and trends incidence, deaths, disability-adjusted life-years (DALYs) for need to be investigated.We extracted data on overall by cause between 1990-2019 from Global Burden Diseases 2019 website, including absolute number corresponding age-standardized incidence (ASIR), deaths (ASDR), DALYs (ASDALYs).Globally, incident cases, increased 74.44, 37.85, 23.46%, respectively, compared with that 1990, an increasing...
This study was designed to investigate the association between polymorphisms in three insulin resistance-related genes, uncoupling protein-1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ) and transcription factor 7-like 2 (TCF7L2) susceptibility diabetic retinopathy (DR) a Chinese type diabetes mellitus (T2DM) cohort. A total of 792 patients with T2DM were enrolled categorized into two groups: (1) DR group consisted 448 patients, which further subclassified proliferative (PDR)...