A5085113170- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
- Data-Driven Disease Surveillance
- Influenza Virus Research Studies
Sun Yat-sen University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Xichang University
2025
First Affiliated Hospital of Zhengzhou University
2014-2024
Anhui Medical University
2014-2024
Sun Yat-sen University Cancer Center
2014-2024
Guangdong Province Women and Children Hospital
2022-2024
First Affiliated Hospital of Anhui Medical University
2014-2024
State Key Laboratory of Oncology in South China
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2003-2023
Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients with advanced esophageal squamous carcinoma (ESCC); however, little is known about the efficacy of PD-1 as neoadjuvant therapy resectable ESCC. We aim to assess safety and feasibility using combination chemotherapy Methods Patients previously untreated, (stage II or III) ESCC were enrolled. Each patient received two 21-day cycles treatment camrelizumab, nab-paclitaxel, carboplatin before undergoing...
Introduction Cereals are an important source of food, feed and fuel with a rapidly increasing global demand. However, cereal seeds contain high levels starch polysaccharides, making the isolation quality RNA extremely difficult. Objective To develop novel method for extracting total from various starch‐ polysaccharides‐rich seeds, such as maize, rice, sorghum wheat. Methodology We developed modified sodium dodecyl sulphate (SDS)/TRIzol method. The combined use Tris buffer (pH 9.0) SDS before...
Human gastric cancers contain a population of cancer stem cells (GCSCs) that can undergo self-renewal and multipotent differentiation. GCSCs be enriched with EpCAM+/CD44+ cells. However, the underlying mechanisms controlling balance GCSC differentiation remain to explored. Because miRNAs regulate cell fates, we compared miRNA expression in tumorspheric more differentiated We found miR-17-92 cluster members miR-19b, miR-20a miR-92a were gradually reduced during GCSCs. Therefore, speculated...
Lung cancer is the leading cause of death in world, and aberrant expression miRNA a common feature during initiation development. Our previous study showed that levels miRNA-148a assessed by quantitative real-time polymerase chain reaction (qRT-PCR) were good prognosis factor for non-small cell lung (NSCLC) patients. In this study, we used high-throughput formalin-fixed paraffin-embedded (FFPE) tissue arrays situ hybridization (ISH) to determine clinical significances aimed find novel target...
Background: The outbreak of coronavirus disease 2019 (COVID-19) has posed stress on the health and well-being people worldwide. Global public interest in this new issue largely reflects people's attention to COVID-19 their willingness take precautionary actions. This study aimed examine global awareness using Google Trends.Methods: Using Trends, we retrieved query data for terms [2019-nCoV + SARS-CoV-2 novel Corona Virus Disease 2019] between 31th Dec 24th Feb 2020 six major English-speaking...
Chemotherapy has improved the survival of patients with gastric cancer by unknown mechanisms. In this study, we showed that cisplatin and docetaxel used in treatment increase expression miRNA-29 (miR-29) family members decrease their oncogenic targets, mediating a significant part efficacious benefits these chemotherapeutic agents. particular, who experienced recurrences after chemotherapy tended to exhibit low levels miR-29c tumors, suggesting activation may contribute efficacy. Enforced...
5-Methylcytosine (m5C) methylation is an important RNA modification pattern that can participate in oncogenesis and progression of cancers by affecting stability, expression oncogenes, the activity cancer signaling pathways. Alterations long non-coding RNAs (lncRNAs) are potentially correlated with abnormalities m5C regulation features cancers. Our aim was to reveal mechanisms which lncRNAs regulated process, explore impact aberrant on biological properties lower-grade gliomas (LGG),...
Multiple-ligament injured knee (MLIK) is a rare but severe injury. Although the principles of MLIK management have progressed over past 40 years, there paucity high-quality evidence upon which to base MLIK. Treatment strategies for are challenging most orthopedic surgeons, and optimal treatment remains controversial, especially with regard repair vs. reconstruction ligaments. The aim present study was observe clinical outcomes single-stage in situ suture dislocation multiple-ligament injury...
Abstract Background Circular RNAs (circRNAs) have been confirmed to be relevant the 5-fluorouracil (5-FU) resistance of breast cancer. Nevertheless, how and whether circRNA F-box leucine-rich repeat protein 5 (circFBXL5) regulates 5-FU cancer is uncertain. This study aims explore function mechanism circFBXL5 in Methods Thirty nine paired normal tissues were harvested. circFBXL5, microRNA-216b (miR-216b) high-mobility group AT-hook 2 (HMGA2) abundances examined via quantitative reverse...
The balance between type 1 and 2 T helper cell cytokine production plays an important role in several animal models of autoimmunity, skewed patterns expression have been described human inflammatory diseases. Many cytokines activate signal transducer activation transcription (STAT) factors, which, turn, effector genes. We used mononuclear priming cultures synovial fluids (SFs) derived from arthritis patients to examine the regulation STAT activity by microenvironment. Exposure SFs during...
Recent studies found that TIPE2 was involved in cancer development. However, little is known about lung cancer. Our study aims to clarify the role of carcinogenesis. We examined expression squamous (LSC), small cell and adenocarcinoma (AdC) tissues lost cancer, compared with adjacent non-tumor tissues. Overexpression significantly inhibited growth H446 vitro even suppressed tumor formation vivo. Flow cytometry analysis overexpression promoted apoptosis H446. In over-expression cells,...
// Junmou Hong 1,* , Zhenguo Liu Hua Zhu 2 Xin Zhang 1 Yongju Liang 3 Shiyuan Yao Fang Wang Xiaoyun Xie 4 Bo Tao Tan Liwu Fu Jing Nie 5 and Chao Cheng Department of Thoracic Surgery, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, People's Republic China Davis Heart Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA Key Laboratory Oncology in South China, Cancer Division Geriatrics, Tongji Hospital, School Medicine, Shanghai, Nephrology,...
microRNAs are commonly dysregulated in a number of human cancers, for example, hepatocellular carcinoma (HCC), but the precise mechanism dysregulation has not been extensively studied. Although previous studies have indicated that HCC cells resistant to endoplasmic reticulum (ER) stress-induced apoptosis, little is known about relationship between and ER stress-mediated apoptosis resistance. In this study, we demonstrated first time expression level miR-663 was significantly upregulated...
Abstract Background Gene mutations may play an important role in the development, response to treatment and prognosis of colorectal cancer (CRC). This retrospective study aimed investigate mutation profiling Chinese patients with CRC, its correlation clinicopathological features prognosis. Methods included 1190 CRC who were diagnosed between May 1998 December 2018 received clinical genetic testing. The OncoCarta Panel was used test a total 238 possible 19 common oncogenes. Results Five...
Estrogen receptor beta (ERβ) is the most highly expressed protein in patients with colon cancer. Matrix metalloproteinase 7 (MMP7) consistently throughout cancer progression. We have previously shown that endocrine therapy can inhibit MMP7 expression cells. In this study, we aim to identify prognostic effects and correlation of ERβ context levels were assessed by immunohistochemistry normal mucosa tumoral tissues from 423 stage I-III The Cox proportional hazards regression model was applied...
Although the Ficoll-Paque method is classically used to isolate peripheral blood mononuclear cells (PBMCs), modifications in this are required for a more rapid and economic output biobanks clinical laboratories, particularly developing countries. In study, we addressed issue by modifying isolation of PBMCs or from umbilical cord healthy diseased (infected, anemic, chronic obstructive pulmonary disease) adult individuals. modified method, initiated cell process buffy coat layer, which appears...
Radiotherapy is frequently applied for clinically localized prostate cancer while its efficacy could be significantly hindered by radioresistance.MicroRNAs (miRNAs) are important regulators in mediating cellular responses to ionizing radiation (IR), and strongly associate with radiosensitivity many cancers.In this study, enhancement of miR-29b-3p was demonstrated cell line LNCaP vitro.Results showed that expression upregulated response IR from both X-rays carbon ion irradiations.Knockdown...
Abstract Background Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will investigate effect BI-2865, a pan-KRAS inhibitor, on reversing induced P-gp, in vitro vivo, its reversal mechanisms be explored. Methods The cytotoxicity BI-2865 removal were tested MTT assays, corresponding function vivo assessed through P-gp mediated KBv200...