A5101615640- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- AI in cancer detection
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Nanchang University
2024
State Key Laboratory of Food Science and Technology
2024
Sun Yat-sen University Cancer Center
2023
Taoyuan Chang Gung Memorial Hospital
2022
Jiangsu University of Science and Technology
2022
Sichuan Agricultural University
2020-2021
Ultrasonic Technologies (United States)
2018-2019
Affiliated Hospital of North Sichuan Medical College
2019
To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative treatment.In total, 156 patients with primary HCC were randomly divided into the training cohort (109 patients) validation (47 patients). From pretreatment images, we extracted 3-phase two-dimensional largest cross-sectional area tumor. A region interest (ROI) was manually delineated around...
Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients with advanced esophageal squamous carcinoma (ESCC); however, little is known about the efficacy of PD-1 as neoadjuvant therapy resectable ESCC. We aim to assess safety and feasibility using combination chemotherapy Methods Patients previously untreated, (stage II or III) ESCC were enrolled. Each patient received two 21-day cycles treatment camrelizumab, nab-paclitaxel, carboplatin before undergoing...
Radiofrequency ablation (RFA) is an important curative therapy in hepatocellular carcinoma (HCC), but recurrence rate remains as high all the other HCC therapeutic modalities. Methyltransferase 1 (METTL1), enzyme for m 7 G tRNA modification, was reported to promote development. Here, we assessed role of METTL1 shaping immunosuppressive tumor microenvironment after insufficient RFA (iRFA).By immunohistochemistry and multiplex immunofluorescence (mIF) staining, showed that expression enhanced...
AIM:To assess the prognostic significance of immunological and nutritional-based indices, including nutritional index (PNI), neutrophillymphocyte ratio (NLR), platelet-lymphocyte in gastric cancer. METHODS:We retrospectively reviewed 632 cancer patients who underwent gastrectomy between 1998 2008.Areas under receiver operating characteristic curve were calculated to compare predictive ability together with estimating sensitivity, specificity agreement rate.Univariate multivariate analyses...
The dynamic N6-methyladenosine (m6 A) mRNA modification is essential for acute stress response and cancer progression. Sublethal heat from insufficient radiofrequency ablation (IRFA) has been confirmed to promote HCC progression; however, whether m6 A machinery involved in IRFA-induced recurrence remains open study.Using an IRFA orthotopic mouse model, we detected a higher level of reader YTH RNA binding protein 1-3 (YTHDF1) the sublethal-heat-exposed transitional zone close center than that...
Abstract A high rate of recurrence after curative therapy is a major challenge for the management hepatocellular carcinoma (HCC). Currently, no effective adjuvant available to prevent HCC recurrence. We designed personalized neoantigen-loaded dendritic cell vaccine and neoantigen-activated T-cell therapy, used it as treat 10 patients with who had undergone resection or radiofrequency ablation in first stage phase II trial (NCT03067493). The primary outcomes were safety neoantigen-specific...
Objective Intrahepatic cholangiocarcinoma (ICC) exhibits very low response rate to immune checkpoint inhibitors (ICIs) and the underlying mechanism is largely unknown. We investigate tumour microenvironment (TIME) of ICCs regulatory mechanisms with aim developing new target inhibit growth improve anti-programmed cell death protein-1 (PD-1) efficacy. Design Tumour tissues from patients ICC together hydrodynamic mouse models were employed identify key population in TIME ICCs. Functional...
Objective Revealing the single-cell immune ecosystems in true versus de novo hepatocellular carcinoma (HCC) recurrences could help optimal development of immunotherapies. Design We performed 5’and VDJ RNA-sequencing on 34 samples from 20 recurrent HCC patients. Bulk RNA-sequencing, flow cytometry, multiplexed immunofluorescence, and vitro functional analyses were two validation cohorts. Results Analyses mutational profiles evolutionary trajectories paired primary using whole-exome sequencing...
The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that are regulator hepatocellular carcinoma (HCC) colorectal cancer metastasis (CRLM) microenvironments. displayed distinct developmental trajectories HCC CRLM. Single-cell analysis revealed IgG+ plasma preferentially accumulated HCC, whereas IgA+ were enriched Mechanistically, recruited by tumor-associated macrophages via the...
Systemic treatments are listed as first-line therapies for HCC with portal vein tumor thrombus (PVTT), resulting in modest efficacy. We aimed to evaluate the efficacy and safety of sintilimab plus bevacizumab combined radiotherapy PVTT identify prognostic biomarkers.
The distinction of intestinal fibrosis from inflammation in Crohn's disease (CD) associated strictures has important therapeutic implications. Ultrasound elastography is useful evaluating the degree liver, but there little evidence whether it can assess bowel. We determined shear-wave (SWE), a novel modification elastography, quantifying tissue stiffness, could differentiate between inflammatory and fibrotic components patients with CD. Consecutive CD ileal/ileocolonic who underwent SWE...
Purpose To retrospectively investigate the safety and efficacy of sorafenib combined with transarterial chemoembolization (TACE) radiofrequency ablation (RFA) (hereafter, TACE-RFA) in treatment recurrent hepatocellular carcinoma (rHCC) portal vein tumor thrombosis, extrahepatic metastases (advanced carcinoma), or both after initial hepatectomy. Materials Methods The study was centrally approved by ethics committee three tertiary medical centers China. From January 2010 to 2015, 207...
This study aims to construct a strategy that uses assistance from artificial intelligence (AI) assist radiologists in the identification of malignant versus benign focal liver lesions (FLLs) using contrast-enhanced ultrasound (CEUS).A training set (patients = 363) and testing 211) were collected our institute. On four-phase CEUS images set, composite deep learning architecture was trained tuned for differentiating FLLs. In test dataset, AI performance evaluated by comparison with varied...
Targeted therapy and immunotherapy are transforming the treatment approach for intrahepatic cholangiocarcinoma (ICC). However, little is known about intertumor heterogeneity (ITH) of multifocal ICC its impacts on patient response to these treatments. We aimed characterize immunogenomic epigenomic guide decision making.We obtained 66 tumor samples from 16 patients with characterized immune using whole-exome sequencing, bulk single-cell RNA methylation microarray, multiplex immunostaining....
Radiofrequency heat ablation is an ideal radical treatment for hepatocellular carcinoma (HCC). However, insufficient radiofrequency (IRFA) could lead to high recurrence of HCC. N
Background and Aims: Scirrhous HCC (SHCC) is one of the unique subtypes HCC, characterized by abundant fibrous stroma in tumor microenvironment. However, molecular traits SHCC remain unclear, which essential to develop specialized therapeutic approaches for SHCC. Approach Results: We presented an integrative analysis containing single-cell RNA-sequencing, whole-exome sequencing, bulk RNA-sequencing usual samples from 134 patients delineate genomic features, transcriptomic profiles, stromal...