A5100392130- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Hepatitis B Virus Studies
- AI in cancer detection
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Photoacoustic and Ultrasonic Imaging
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
Peking University
2010-2025
Anhui Medical University
2011-2025
Wenzhou Medical University
2017-2025
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2025
Beijing Friendship Hospital
2017-2025
Capital Medical University
2012-2025
Shandong Maternal and Child Health Hospital
2025
Qingdao University
2015-2025
Tiangong University
2025
Discovery Institute
2018-2025
ContextGlucose-insulin-potassium (GIK) infusion is a widely applicable, low-cost therapy that has been postulated to improve mortality in patients with acute ST-segment elevation myocardial infarction (STEMI). Given the potential global importance of GIK infusion, large, adequately powered randomized trial required determine effect on STEMI.ObjectiveTo high-dose STEMI.Design, Setting, and ParticipantsRandomized controlled conducted 470 centers worldwide among 20 201 STEMI who presented...
MicroRNA (miR)-133a regulates cardiac and skeletal muscle differentiation plays an important role in development. Because miR-133a levels decrease during reactive hypertrophy, some have considered that restoring could suppress hypertrophic remodeling.To prevent the "normal" downregulation of induced by acute stimulus adult heart.miR-133a is downregulated transverse aortic constriction (TAC) isoproterenol-induced but not 2 genetic hypertrophy models. Using MYH6 promoter-directed expression a...
BackgroundStrategies for integrating artificial intelligence (AI) into thyroid nodule management require additional development and testing. We developed a deep-learning AI model (ThyNet) to differentiate between malignant tumours benign nodules aimed investigate how ThyNet could help radiologists improve diagnostic performance avoid unnecessary fine needle aspiration.MethodsThyNet was trained on 18 049 images of 8339 patients (training set) from two hospitals (the First Affiliated Hospital...
Hepatitis B virus (HBV) reactivation is a serious complication for patients with lymphoma treated rituximab-containing chemotherapies, despite lamivudine prophylaxis treatment. An optimal prophylactic antiviral protocol has not been determined.To compare the efficacy of entecavir and in preventing HBV seropositive hepatitis surface antigen untreated diffuse large B-cell receiving chemotherapy treatment rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP).Randomized,...
To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative treatment.In total, 156 patients with primary HCC were randomly divided into the training cohort (109 patients) validation (47 patients). From pretreatment images, we extracted 3-phase two-dimensional largest cross-sectional area tumor. A region interest (ROI) was manually delineated around...
Injudicious or inappropriate use of antibiotics has led to the prevalence drug-resistant bacteria, posing a huge menace global health. Here, self-assembled aggregation-induced emission (AIE) nanosphere (AIE-PEG1000 NPs) that simultaneously possesses near-infrared region II (NIR-II) fluorescence emissive, photothermal, and photodynamic properties is prepared using multifunctional AIE luminogen (AIE-4COOH). The AIE-PEG1000 NPs were encapsulated with teicoplanin (Tei) ammonium bicarbonate (AB)...
Background Large language models (LLMs) hold substantial promise for medical imaging interpretation. However, there is a lack of studies on their feasibility in handling reasoning questions associated with diagnosis. Purpose To investigate the viability leveraging three publicly available LLMs to enhance consistency and diagnostic accuracy based standardized reporting, pathology as reference standard. Materials Methods US images thyroid nodules pathologic results were retrospectively...
Chronic kidney disease (CKD) is a prevalent life-threatening frequently associated with hypertension, progression to renal fibrosis, and eventual failure. Although the pathogenesis of CKD remains largely unknown, an increased inflammatory response known be has long been speculated contribute development. However, causative factors, exact role cascade in CKD, underlying mechanisms for its remain unidentified. Here we report that interleukin 6 (IL-6) expression levels were significantly...
Thioredoxin-interacting protein (TXNIP), a regulator of cellular oxidative stress, has been associated with activation NOD-like receptor 3 (NLRP3) inflammasome, inflammation and lipid metabolism, suggesting it role in the pathogenesis non-alcoholic fatty liver disease (NAFLD) diabetes. In this study we investigated whether TXNIP is involved type 1 diabetes-associated NAFLD antioxidants, quercetin allopurinol, alleviate by targeting TXNIP.Diabetes was induced male Sprague-Dawley rats single...
To develop and validate a radiomics signature for the prediction of gastric cancer (GC) survival chemotherapeutic benefits. In this multicenter retrospective analysis, we analyzed features portal venous-phase computed tomography in 1591 consecutive patients. A was generated by using Lasso-Cox regression model 228 patients validated internal external validation cohorts. Radiomics nomograms integrating were constructed, demonstrating incremental value to traditional staging system...
Abstract Oleic acid (OA), a main ingredient of Brucea javanica oil (BJO), is widely known to have anticancer effects in many tumors. In this study, we investigated the effect OA and its mechanism tongue squamous cell carcinoma (TSCC). We found that effectively inhibited TSCC proliferation dose- time-dependent manner. treatment significantly induced cycle G0/G1 arrest, increased proportion apoptotic cells, decreased expression CyclinD1 Bcl-2, p53 cleaved caspase-3. also obviously formation...
The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that is phosphorylated by its upstream kinase, Lats1/2, multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation believed inhibit excluding it from the nucleus. Indeed, nuclear localization of or decreased at this (S168 in Drosophila , S127 humans, S112 mice) widely used current literature as a...
Hepatic infiltration of neutrophils is a hallmark steatohepatitis; however, the role in progression steatohepatitis remains unknown.
hsa-miR-191 is highly expressed in hepatocellular carcinoma (HCC), but the factors regulating this elevated expression are unknown. This study aimed to investigate epigenetic mechanisms of increased by analyzing relationship between DNA methylation status and miR-191 expression. Methylation-specific polymerase chain reaction (PCR), bisulfite sequencing PCR, Northern blot, quantitative real-time PCR were performed examine levels. Western transwell, scratch assays function molecular...
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this is regulated in development remains major challenge. Recent studies suggested signaling can be modulated by cytoskeletal tension Rok-myosin II pathway. How or its relationship to other known upstream regulators poorly defined. In study, we identify spectrin, contractile protein at cytoskeleton-membrane interface, as an regulator We show...
Abstract Radiomics reflects the texture and morphological features of tumours by quantitatively analysing grey values medical images. We aim to develop a nomogram incorporating radiomics Breast Imaging Reporting Data System (BI-RADS) for predicting breast cancer in BI-RADS ultrasound (US) category 4 or 5 lesions. From January 2017 August 2018, total 315 pathologically proven lesions were included. Patients from study population divided into training group (n = 211) validation 104) according...
Background Simvastatin exerts pleiotropic effects on cardiovascular system. However, its effect non-alcoholic fatty liver disease, especially the fibrosis, remains obscure. We aimed to clarify relationship between simvastatin and fibrosis both in vivo vitro. Methods A High-fat diet was given establish rat models with steatohepatitis (NASH)-related (4mg·kg-1·d-1) administrated intragastrically until hepatic histological findings confirmed appearance of fibrosis. Human stellate cell (HSC) line...
To assess significant liver fibrosis by multiparametric ultrasomics data using machine learning. This prospective study consisted of 144 patients with chronic hepatitis B. Ultrasomics—high-throughput quantitative from ultrasound imaging fibrosis—were generated conventional radiomics, original radiofrequency (ORF) and contrast-enhanced micro-flow (CEMF) features. Three categories features were explored pairwise correlation hierarchical clustering. Features selected diagnostic tests for...