A5100694792- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
- PI3K/AKT/mTOR signaling in cancer
- Phytochemistry and Biological Activities
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Genomics and Diagnostics
- FOXO transcription factor regulation
- Nuclear Receptors and Signaling
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Stochastic Gradient Optimization Techniques
- Privacy-Preserving Technologies in Data
Shanghai Jiao Tong University
2021-2025
Nanjing University
2025
Nanjing General Hospital of Nanjing Military Command
2025
Northeast Agricultural University
2023-2025
Guangxi Medical University
2014-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Target (United States)
2024
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
China Institute of Atomic Energy
2024
Axonal regeneration and functional recovery after complete spinal cord injury (SCI) are limited in adult mammals. The purpose of this study was to investigate whether an innovative composite matrix made from a denuded human amniotic membrane (DHAM) seeded with bone marrow stromal cells (BMSCs) could promote axonal SCI. We transplanted the between stumps severed cords immediately following Twelve weeks surgery, hindlimbs operated rats evaluated by Basso-Beattie-Bresnahan (BBB) locomotor...
DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging diseases. Therefore, genome-wide mapping of DMRs across various temporal spatial methylomes is revealing the impact epigenetic modifications on heritable phenotypic variation. We present a quantitative approach, differentially (QDMRs), to quantify difference identify from profiles by adapting Shannon entropy....
hsa-miR-191 is highly expressed in hepatocellular carcinoma (HCC), but the factors regulating this elevated expression are unknown. This study aimed to investigate epigenetic mechanisms of increased by analyzing relationship between DNA methylation status and miR-191 expression. Methylation-specific polymerase chain reaction (PCR), bisulfite sequencing PCR, Northern blot, quantitative real-time PCR were performed examine levels. Western transwell, scratch assays function molecular...
Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver. However, the molecular mechanisms responsible for steroid-induced remain largely enigmatic. Here, we show that hepatic Krüppel-like factor 9 (Klf9) gene expression is induced by dexamethasone fasting. The overexpression of Klf9 in primary hepatocytes strongly stimulated Pgc1a through direct binding to its promoter, thereby activating gluconeogenic program. mutation abolished stimulatory effect on...
AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, members of which catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. plays important role tumor progression metastasis, however, little known about function molecular mechanism underlying hepatocellular carcinoma (HCC). In this study, we report that significantly upregulated HCC increased associated with poor survival. positively regulated cell proliferation metastasis
Abstract Epilepsy is a chronic brain disease characterized by recurrent seizures. Circular RNA (circRNA) novel family of endogenous non‐coding RNAs that have been proposed to regulate gene expression. However, there lack data on the role circRNA in epilepsy. In this study, profiles were evaluated microarray analysis. total, 627 circRNAs up‐regulated, whereas 892 down‐regulated hippocampus mice with kainic acid (KA)‐induced epileptic seizures compared control. The expression circHivep2 was...
Abstract Zinc finger protein 143 (ZNF143) belongs to the zinc family and possesses transcription factor activity by binding sequence-specific DNA. The exact biological role of ZNF143 in hepatocellular carcinoma (HCC) has not been investigated. Here we report that is overexpressed HCC tissues its overexpression correlates with poor prognosis. Gain- loss-of-function experiments showed promoted cell proliferation, colony formation, tumor growth vitro vivo. accelerated cell-cycle progression...
Abstract Osteosarcoma is a common malignant bone tumour characterised by an aggressive metastatic potential. The microenvironment, particularly the M2‐polarised macrophages, crucial for progression. Cucurbitacin B (CuB), triterpenoid derivative, recognised its anti‐inflammatory and antitumour properties. This study investigates CuB effect on M2 macrophage differentiation osteosarcoma progression, aiming to contribute new treatment strategies. In vitro, THP‐1 monocytes were stimulated with...
Phytopathogen Xanthomonas campestris pv (Xcc) uses various mechanisms, including the quorum sensing (QS) system, to regulate infection and colonize cruciferous host plants. Hydroxycinnamic acids (HCAs) are widely distributed in plant kingdom, but their effect on diffusible signaling factor family QS signal of Xcc remains unknown. In this study, we report that HCAs activate RpfB-dependent turnover via sensor protein HepR, which turn activates HepABCD resistance-nodulation-division efflux pump...
Ribonucleotide reductase (RR)M2B is an enzyme belonging to the ribonucleotide family, which essential for DNA synthesis and repair. RRM2B plays important role in tumor progression metastasis; however, little known about expression underlying molecular mechanisms of hepatocellular carcinoma (HCC). In present study, we report that down-regulation HCC negatively associated with intrahepatic metastasis, regardless p53 status. Moreover, ectopic overexpression decreased cell migration invasion...
Abstract Accumulating evidence indicates that heat shock protein (HSP) 60 is strongly associated with the pathology of atherosclerosis (AS). However, precise mechanisms by which HSP60 promotes remain unclear. In present study, we found mRNA and expression levels in thoracic aorta are enhanced not only a mouse model AS but also high-fat diet (HFD) mice. secretion was activated platelet-derived growth factor-BB (PDGF-BB) interleukin (IL)-8 both human umbilical vein endothelial cells (HUVECs)...
Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chronic hepatitis B virus (HBV) infection remains major risk factor for HCC. this study, we performed a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci contributing susceptibility HBV-related HCC.Experimental Design: GWAS scan in collection 205 HCC trios (each trio includes an affected proband and his/her both parents), 355 HBV carriers with (cases) 360...
Rosamultin is one of the main active compounds isolated from Potentilla anserina L., which belongs to a triterpene compound. Few studies have examined effect rosamultin on oxidative stress and its molecular mechanism. The aim this present study was elucidate protective H 2 O ‐induced damage apoptosis in H9c2 cardiomyocytes results showed that pretreatment not only increased cell viability but also reduced release LDH CK. inhibited decrease SOD, CAT, GSH‐Px activities an increase MDA content....