A5100454598- Prostate Cancer Treatment and Research
- Berberine and alkaloids research
- Synthesis and Biological Activity
- Phytochemical Studies and Bioactivities
- Hormonal and reproductive studies
- Aortic Disease and Treatment Approaches
- Estrogen and related hormone effects
- Aortic aneurysm repair treatments
- Prostate Cancer Diagnosis and Treatment
- Selenium in Biological Systems
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
Nanjing Drum Tower Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2025
Peking Union Medical College Hospital
2025
Shanghai University of Traditional Chinese Medicine
2024
Guangdong Medical College
2015-2024
Tulane University
2011-2024
Soochow University
2015-2024
First Affiliated Hospital of Soochow University
2024
Shandong First Medical University
2023-2024
Suzhou Traditional Chinese Medicine Hospital
2024
Abstract Purpose: We evaluated the association of PSA and androgen receptor splice variant-7 (AR-V7) transcript levels in patients' blood with time to treatment failure (TTF) overall survival (OS) abiraterone acetate and/or enzalutamide castration-resistant prostate cancer (CRPC) patients. Experimental Design: RNA AR-V7 peripheral collected before were quantified using droplet digital-PCR retrospective cohorts treated (N = 81) or 51) for CRPC. Multivariable Cox regression adjusted known...
Vascular endothelial growth factor (VEGF) inhibition has been demonstrated to be an effective strategy in preserving the integrity of blood-brain barrier (BBB) patients with acute ischemic stroke. Loss BBB is key event associated morbidity and mortality these patients. However, underlying mechanisms remain poorly understood. In present study, effects VEGF possible mechanism that underlies cerebral ischemia rats was investigated. Following induction transient middle artery occlusion for a...
Reprogramming of lipid metabolism, which modulates energy utilization and cell signaling, maintains survival promotes cancer metastasis in cells. Ferroptosis is a type necrosis caused by an overload oxidation, has been demonstrated to be involved metastasis. However, the mechanism fatty acid metabolism regulates anti-ferroptosis signaling pathways not fully understood. The formation ovarian spheroids helps counteract hostile microenvironment peritoneal cavity with low oxygen, shortage...
A previous controlled intervention trial showed that selenium supplementation was effective in reducing the incidence of prostate cancer. Physiological concentrations have also been reported to inhibit growth human cancer cells vitro. The present study describes observation able significantly down-regulate expression prostate-specific antigen (PSA) transcript and protein within hours androgen-responsive LNCaP cells. Decreases androgen receptor (AR) followed a similar dose time response...
Doxorubicin is an effective drug against breast cancer. However, the favorable therapeutic response to doxorubicin often associated with severe toxicity. The present research was aimed at developing a strategy of increasing sensitivity so that lower doses may be used without compromising efficacy. MCF-7 human cancer cell line currently in use our laboratory did not respond killing during 24-h treatment period. By combining selenium, we were successful producing brisk enhancement apoptosis....
AIM:To investigate the mechanism by which galangin, a polyphenolic compound derived from medicinal herbs, induces apoptosis of hepatocellular carcinoma (HCC) cells. METHODS:The 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay was used to measure cell viability.Apoptosis evaluated in situ uptake propidium iodide and Hoechst 33258 then detected fluorescence microscopy.Protein expressions were Western blotting.To confirm apoptotic pathway mediated cells transfected bcl-2...
// Guanyi Zhang 1, 2, 6 , Xichun Liu Jianzhuo Li Elisa Ledet 4, 5, Xavier Alvarez 7 Yanfeng Qi 3, Xueqi Fu 1 Oliver Sartor Yan Dong Haitao College of Life Sciences, Jilin University, Changchun, P.R. China 2 Department Pathology, Tulane University School Medicine, New Orleans, Louisiana, USA 3 Structural and Cellular Biology, 4 5 Urology, Cancer Center, Division Comparative National Primate Research Covington, Correspondence to: Zhang, e-mail: hzhang@tulane.edu Keywords: androgen receptor,...
Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical characteristics and risk factors severe infection in Chinese patients AAV after therapy. A total 248 a new diagnosis ANCA-associated were included this study. The incidence, time, site, by induction therapies analysed. Multivariate Cox proportional hazards models used to calculate hazard...
Abstract Galangin suppresses proliferation and induces apoptosis autophagy in hepatocellular carcinoma (HCC) cells, but the precise mechanism is not clear. In this study, we demonstrated that galangin induced autophagy, enhanced binding of SIRT1-LC3 reduced acetylation endogenous LC3 HepG2 cells. But was inhibited by inactivation SIRT1 meanwhile, failed to reduce after knocked-down. Collectively, these findings demonstrate a new which via deacetylation SIRT1.
Abstract Androgen receptor splice variants (AR-V) are implicated in resistance of prostate cancer to androgen-directed therapies. When expressed alone cells, some AR-Vs (e.g., AR-V7) localize primarily the nucleus, whereas others AR-V1, AR-V4, and AR-V6) mainly cytoplasm. Significantly, latter often coexpressed with nucleus-predominant full-length AR (AR-FL). An important question be addressed is whether cytoplasmic-localized play a role castration-resistant (CRPC) through interaction AR-FL....
Aldo-keto reductase family 1 member C3 has recently been regarded as a potential therapeutic target in castrate-resistant prostate cancer. Herein, we investigated whether berberine delayed the progression of cancer by reducing androgen synthesis through inhibition C3. Cell viability and cellular testosterone content were measured cells. mRNA protein level detected RT-PCR Western bolt analyses, respectively. Computer analysis with AutoDock Tools explored molecular interaction We found that...
The incidence of papillary thyroid cancer (PTC) shows a predominance in females, with male:female ratio 1:3, and none the known risk factors are associated gender difference. Increasing evidence indicates role estrogen tumorigenesis, but mechanism involved remains largely unknown. This study aimed to assess contribution autophagy receptor α (ERα)-mediated growth PTC. expression ERα tissue patients PTC tissues was analyzed. Cell viability, proliferation, apoptosis were evaluated after...
Despite its side-effects, docetaxel (DTX) remains a first-line treatment against castration resistant prostate cancer (CRPC). Therefore, strategies to increase anti-tumor efficacy and decrease side effects are critically needed. Targeting of the constitutive endoplasmic reticulum (ER) stress in cells is being investigated as chemosensitization approach. We hypothesized that simultaneous induction ER-stress suppression PI3K/AKT survival pathway will be more effective In CRPC cell line, C4-2B,...
Aldo-keto reductase family 1 member C3 (AKR1C3) is a key steroidogenic enzyme that overexpressed in prostate cancer (PCa) and associated with the development of castration-resistant (CRPC). The aim this study was to investigate correlation between expression level AKR1C3 progression PCa. Sixty human needle biopsy tissue specimens ten LNCaP xenografts from intact or castrated male mice were included study. relationship by immunohistochemistry evaluation factors for PCa progression, including...
No AccessJournal of UrologyInvestigative Urology1 Dec 2016A Whole Blood Assay for AR-V7 and ARv567es in Patients with Prostate Cancer Xichun Liu, Elisa Ledet, Dongying Li, Ary Dotiwala, Allie Steinberger, Allison Feibus, Jianzhuo Yanfeng Qi, Jonathan Silberstein, Benjamin Lee, Yan Dong, Oliver Sartor, Haitao Zhang LiuXichun Liu Department Pathology, Tulane University School Medicine, New Orleans, Louisiana Center, Equal study contribution. More articles by this author , LedetElisa Ledet...
Lung cancer is the widespread carcinogenesis in men and third most familiar women. It one of mostly aggressive human cancers, which responsible for around 1.4 million deaths per annum has utmost mortality incidence with 1.8 new incidences 1.6 yearly. In this present study, we have evaluated anticancer potential zinc oxide nanopartices (ZnONPs) synthesized from a root extract Euphorbia fischeriana (EF), through apoptosis signaling markers A549 lung cells. The EF-ZnONPs were transmission...
Background: This study aims to analyze the clinical characteristics and factors influencing postoperative limb function recovery in patients with acute type A aortic dissection (ATAAD) complicated by lower extremity malperfusion (LEM). The objective is accurately assess preoperative conditions, identify manage risk factors, improve surgical techniques, offer insights enhance rate of LEM following surgery. Methods: retrospective included 131 ATAAD LEM, admitted Department Cardiothoracic...