A5002440088- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Treatment and Research
- Neurological disorders and treatments
- Prostate Cancer Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Wound Healing and Treatments
- Hormonal and reproductive studies
- Cerebrospinal fluid and hydrocephalus
- Genetic factors in colorectal cancer
- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- Ginkgo biloba and Cashew Applications
- Neurological and metabolic disorders
- Acute Ischemic Stroke Management
- Reconstructive Surgery and Microvascular Techniques
- Autism Spectrum Disorder Research
- Peptidase Inhibition and Analysis
- Laser Material Processing Techniques
- Botulinum Toxin and Related Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
Inje University Sanggye Paik Hospital
2021-2025
Seoul National University Hospital
2025
Seoul National University Bundang Hospital
2025
Yonsei University
2015-2024
Samsung (South Korea)
2024
Inje University Ilsan Paik Hospital
2023
Chung-Ang University
2023
Circuit Therapeutics (United States)
2022
Inje University Busan Paik Hospital
2021-2022
Inje University
2022
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies content in 0.1× coverage whole-genome data without prior knowledge mutations. We apply ichorCNA to 1439 samples 520 patients with metastatic prostate or breast cancers. In earliest tested sample for each patient, 34% have ≥10% tumor-derived cfDNA, sufficient...
Significance The results of the recent clinical trials, ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) and Systemic Advanced or Metastatic Cancer: Evaluation Drug Efficacy (STAMPEDE), suggest a significant contribution androgen receptor signaling to sensitivity docetaxel prostate cancer. This study provides evidence that KDM5D (lysine-specific demethylase 5D) encoded on Y chromosome plays an important role by interacting...
Abstract Purpose: We evaluated the association of PSA and androgen receptor splice variant-7 (AR-V7) transcript levels in patients' blood with time to treatment failure (TTF) overall survival (OS) abiraterone acetate and/or enzalutamide castration-resistant prostate cancer (CRPC) patients. Experimental Design: RNA AR-V7 peripheral collected before were quantified using droplet digital-PCR retrospective cohorts treated (N = 81) or 51) for CRPC. Multivariable Cox regression adjusted known...
Background The choroid plexus (CP) is involved in the clearance of harmful metabolites from brain, as a part glymphatic system. This study aimed to investigate association between CP volume (CPV), nigrostriatal dopaminergic degeneration and motor outcomes Parkinson’s disease (PD). Methods We retrospectively searched drug-naïve patients with early-stage PD who underwent dopamine transporter (DAT) scanning MRI. Automatic segmentation was performed, CPV calculated. relationship CPV, DAT...
As a part of the glymphatic system, choroid plexus (CP) is involved in clearance harmful metabolites from brain. We investigated association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition patients on Alzheimer's disease (AD) continuum. retrospectively reviewed records 203 AD continuum 82 healthy controls who underwent brain magnetic resonance imaging <sup>18</sup>F-florbetaben positron emission tomography. Automatic segmentation was performed, CPV calculated. Cognitive...
Epigenetic modifications control cancer development and clonal evolution in various types. Here, we show that loss of the male-specific histone demethylase lysine-specific 5D (KDM5D) encoded on Y chromosome epigenetically modifies methylation marks alters gene expression, resulting aggressive prostate cancer. Fluorescent situ hybridization demonstrated segmental or total deletion cells is one causes decreased KDM5D mRNA expression. The result ChIP-sequencing analysis revealed preferably...
Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors are widely used hypoglycaemic agents and improve glucose metabolism by enhancing the bioavailability of active glucagon-like peptide-1. In this study, we hypothesized that treatment with DPP4 may have beneficial effects on nigrostriatal dopamine longitudinal motor performance in diabetic patients Parkinson’s disease. We classified 697 drug naive de novo disease who had undergone transporter imaging into three groups according to a prior...
We evaluated the patterns of quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD), Lewy body (LBD), and mixed disease. Sixteen AD, 38 LBD, 20 disease, 17 control participants were recruited underwent EEG. The theta/alpha ratio theta/beta measured. relationship log-transformed (TAR) (TBR) group, presence AD clinical symptoms evaluated. Participants LBD groups had higher TBR all lobes except for occipital lobe than those group. was independently associated...
Abstract Background and purpose The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of glymphatic system. We investigated association CP volume (CPV) with baseline longitudinal cognitive decline in patients Parkinson disease (PD). Methods retrospectively reviewed medical records 240 newly diagnosed PD who had undergone detailed neuropsychological tests high‐resolution T1‐weighted structural magnetic resonance imaging during initial assessment. CPV each...
Statins are more widely used not only for the primary and secondary prevention of cardiovascular disease by blocking cholesterol biosynthesis but also potential neuroprotective agents during neurological disorders due to their pleiotropic effects. In this study, we investigate whether previous use statins affect baseline nigrostriatal dopamine loss at time diagnosis longitudinal motor cognitive outcomes in patients with Parkinson's disease. Five hundred drug-naïve who underwent transporter...
To investigate the effects of enlarged perivascular space (EPVS) on amyloid burden and cognitive function in Alzheimer disease (AD) continuum.We retrospectively reviewed 208 patients with AD across continuum (preclinical, prodromal, dementia) who showed deposition 18F-florbetaben PET scans 82 healthy controls. EPVSs were counted for each patient basal ganglia (BG), centrum semiovale (CSO), hippocampus (HP) axial T2-weighted images. Patients then classified according to number into EPVS+ (>10...
Abstract Background White matter hyperintensities, prevalent in patients with Parkinson's disease (PD), significantly affect parkinsonian motor symptoms. The objective of this study was to investigate the relationship between white hyperintensities and nigrostriatal dopamine depletion their interaction or mediating effects on symptoms drug‐naive early‐stage PD. Methods This cross‐sectional enrolled 501 de novo PD who initially underwent [ 18 F]...
Abstract Patients with dementia Lewy bodies (DLB) show widespread brain metabolic changes. This study investigated whether hypo- and hypermetabolism in DLB have differential effects on cognition. We enrolled 55 patients (15 prodromal [MCI-LB] 40 probable DLB) 13 healthy controls who underwent 18 F-fluorodeoxyglucose positron emission tomography detailed neuropsychological tests. Metabolic indices reflecting associated changes regional cerebral glucose metabolism were calculated as follows:...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder and characterized by progressive dopaminergic non-dopaminergic neuronal loss presence of Lewy bodies, which are primarily composed aggregated α-synuclein. Despite advancements in symptomatic therapies, such as dopamine replacement deep brain stimulation, no disease-modifying therapies (DMTs) have been identified to slow or arrest neurodegeneration PD. Challenges DMT development include heterogeneity, absence...
<sec> <title>BACKGROUND</title> A decline in applications to vital medical specialties, particularly general surgery, obstetrics and gynecology, pediatrics Republic of Korea threatens the nation's healthcare infrastructure. Despite multiple contributing factors, there is limited qualitative research exploring students' specialty choice decisions. </sec> <title>OBJECTIVE</title> This study aimed examine key factors influencing Korean selection processes, identify how recent policy changes...
To investigate whether dipeptidyl peptidase-4 inhibitors (DPP-4i) have beneficial effects on amyloid aggregation and longitudinal cognitive outcome in diabetic Alzheimer disease-related impairment (ADCI).We retrospectively reviewed 282 patients with ADCI positive 18F-florbetaben PET images. Patients were classified into 3 groups according to prior diagnosis of diabetes DPP-4i use: being treated (ADCI-DPP-4i+, n = 70) or without (ADCI-DPP-4i-, 71) nondiabetic (n 141). Multiple linear...
Abstract Dementia with Lewy bodies (DLB), the second most common neurodegenerative dementia, is characterized by cognitive decline, fluctuation of cognition and alertness, visual hallucinations, rapid eye movement sleep behaviour disorder parkinsonism. Imaging biomarkers are great importance in diagnosing patients DLB associated characteristic clinical features including decline. In this study, we investigate interrelation between nigrostriatal dopamine depletion, brain metabolism DLB. We...
Patients with Parkinson's disease (PD) exhibit widespread brain perfusion changes.This study investigated whether cerebral regions hypoperfusion and hyperperfusion have differential effects on motor cognitive symptoms in PD using early-phase 18 F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18 F-FP-CIT) positron emission tomography (PET) scans.We enrolled 394 patients newly diagnosed who underwent dual-phase F-FP-CIT PET scans. Indices reflecting associated changes...
Neuropsychiatric symptoms (NPS) are closely associated with cognitive decline in patients Parkinson disease (PD). We investigated which profiles of NPS the risk dementia PD mild impairment (PD-MCI).
Although hypertension is a critical risk factor for dementia, the association between primary aldosteronism (PA) and dementia has been scarcely reported. We aimed to investigate whether of in patients with PA was elevated compared essential (EH).From National Health Insurance Claim database Korea (2003-2017), 3,687 (adrenalectomy [ADX], n = 1,339, mineralocorticoid receptor antagonist [MRA] 2,348) no prior were age- sex-matched at 1:4 ratio EH (n 14,741). The outcomes all-cause events,...
Individual variability in nigrostriatal dopaminergic denervation is an important factor underlying clinical heterogeneity Parkinson disease (PD). This study aimed to explore whether the pattern of striatal dopamine depletion was associated with white matter (WM) networks PD.A total 240 newly diagnosed patients PD who underwent 18F-FP-CIT PET scans and brain diffusion tensor imaging at initial assessment were enrolled this study. We measured tracer uptake as indirect marker for depletion....