A5014492572- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- International Student and Expatriate Challenges
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Human Resource and Talent Management
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Educational and Psychological Assessments
- Renal cell carcinoma treatment
- International Business and FDI
- Migration, Ethnicity, and Economy
- FOXO transcription factor regulation
- Cancer-related gene regulation
- Higher Education and Employability
- Cancer, Lipids, and Metabolism
- Family Business Performance and Succession
- Genetic Mapping and Diversity in Plants and Animals
- Gender Diversity and Inequality
- Employer Branding and e-HRM
- Higher Education Governance and Development
- Clinical Laboratory Practices and Quality Control
- Counseling Practices and Supervision
National University of Ireland, Maynooth
2017-2025
University of South Australia
2024
CSIRO Health and Biosecurity
2024
Commonwealth Scientific and Industrial Research Organisation
2024
Dana-Farber Cancer Institute
2016-2023
Harvard University
2020-2022
Muscular Dystrophy UK
2017
Lovelace Respiratory Research Institute
2017
Military Manpower Administration
2012
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies content in 0.1× coverage whole-genome data without prior knowledge mutations. We apply ichorCNA to 1439 samples 520 patients with metastatic prostate or breast cancers. In earliest tested sample for each patient, 34% have ≥10% tumor-derived cfDNA, sufficient...
BACKGROUND Breast cancer 2 ( BRCA2 )‐associated breast and ovarian cancers are sensitive to platinum‐based chemotherapy. It is unknown whether ‐associated prostate responds favorably such treatment. METHODS A retrospective analysis of a single‐institution cohort men with castration‐resistant, metastatic was performed determine the association between carrier status pathogenic germline variants prostate‐specific antigen response carboplatin‐based From 2001 through 2015, 8081 adult who had...
Abstract Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism adaptive resistance targeted therapy in cancer. An archetypal example development neuroendocrine prostate cancer (NEPC) after treatment adenocarcinoma (PRAD) with inhibitors androgen signaling. NEPC aggressive variant that aberrantly expresses genes characteristic (NE) tissues and no longer depends on androgens. Here, we investigate epigenomic basis this by profiling histone...
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC overexpressed in both early metastatic disease associated with poor survival, its impact on transcriptional reprogramming remains elusive. We demonstrate that overexpression significantly diminishes the androgen receptor (AR) program (the set genes directly targeted by AR protein) luminal cells without altering expression. Analyses clinical specimens reveal concurrent low high programs...
BACKGROUND. Tumor content in circulating cell-free DNA (cfDNA) is a promising biomarker, but longitudinal dynamics of tumor-derived and non–tumor-derived cfDNA through multiple courses therapy have not been well described.
Defects in genes the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that overexpression of may also drive poorer outcomes cancer. The ribonucleotide reductase small subunit M2 (RRM2) is essential for synthesis and by producing dNTPs. It frequently overexpressed cancers, but very little known about its function
While the mutational and transcriptional landscapes of renal cell carcinoma (RCC) are well-known, epigenome is poorly understood. We characterize clear (ccRCC), papillary (pRCC), chromophobe RCC (chRCC) by using ChIP-seq, ATAC-Seq, RNA-seq, SNP arrays. integrate 153 individual data sets from 42 patients nominate 50 histology-specific master transcription factors (MTF) to define histologic subtypes, including EPAS1 ETS-1 in ccRCC, HNF1B pRCC, FOXI1 chRCC. confirm MTFs via immunohistochemistry...
Abstract Although Response to Intervention (RtI) implementation efforts have been occurring in schools across the country for more than a decade, questions and concerns are emerging, as some not observing significantly improved student achievement or behavior outcomes expected. In literature on RtI implementation, most authors indicate there multiple levels of support that required effective implementation. These include individual professional development regarding rationale developing...
Is it time to reimagine the kaleidoscope career model (KCM) beyond gendered patterns? In this article, we draw upon KCM in a novel way show how skilled migrants, just like kaleidoscope, adjust their parameters and construct bespoke paths order cope with disruption of an international move. Specifically, study unpacks careers 38 migrants Ireland suggests alternative explanation for migrants’ underemployment. The findings that macro transition – from home host country presents both...
Abstract Based on existing Talent Management (TM) literature, this conceptual paper presents an integrated TM framework with principles for decision‐making and potential research avenues future studies. This aims to address the tensions biases related inclusive exclusive approaches offers a new approach guide practice in processes beyond extant ‘either/or’ partially approaches.
Purpose Externalities influence the career trajectories of self-initiated expatriates (SIEs) and their respective crafting. This study aims to explore international crafting SIEs (encompassing proactive reflection construction), taking combined external influences complexity, chance change into consideration. Design/methodology/approach The authors employ a qualitative (interpretative) approach, combining chaos theory careers (CTC) further understand, from an individual standpoint, impact...
The androgen receptor (AR) is a master transcription factor that regulates prostate cancer (PC) development and progression. Inhibition of AR signaling by deprivation the first-line therapy with initial efficacy for advanced recurrent PC. Paradoxically, supraphysiological levels testosterone (SPT) also inhibit PC However, as any therapy, not all patients show therapeutic benefit, responses differ widely in magnitude duration. In this study, we evaluated whether differences cistrome before...
Purpose This micro-level study unpacks the recruitment and retention of international professionals to small medium-sized enterprises (SMEs). The highlights influence founders' experience when applying organisational-level (meso) policies practices. With their insider as skilled migrants, we share how founders in each SMEs mobilised career capital into human resource management (HRM) strategies. Design/methodology/approach Combining literature on migrants' careers, draw upon intelligent...
The 10th Global CRO Council (GCC) Closed Forum was held in Orlando, FL, USA on 18 April 2016. In attendance were decision makers from international member companies offering bioanalytical services. objective of this meeting for GCC members to meet and discuss scientific regulatory issues specific bioanalysis. discussed at closed forum included reporting data failed method validation runs, GCP clinical sample bioanalysis, extracted stability, biomarker assay validation, processed batch...
195 Background: Quantification of circulating free DNA (cfDNA) has been proposed both as a prognostic biomarker and response resistance to therapy. However, dynamics cfDNA derived from tumor non-cancerous tissues through dense longitudinal monitoring over the course treatment with multiple therapeutic modalities have not well described. Methods: CfDNA isolated banked prospectively collected plasma samples pts metastatic castration-resistant prostate cancer (mCRPC) was subject ultra-low pass...