A5078027978- Prostate Cancer Treatment and Research
- Neonatal Respiratory Health Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infant Nutrition and Health
- Immune cells in cancer
- Congenital Diaphragmatic Hernia Studies
- Hormonal and reproductive studies
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Metabolism and Genetic Disorders
- Cancer Treatment and Pharmacology
- Urinary and Genital Oncology Studies
- Congenital Heart Disease Studies
- Multiple and Secondary Primary Cancers
- Diabetes Management and Research
Brown University
2015-2025
AdventHealth for Children
2018-2025
Research Network (United States)
1996-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1996-2025
Icahn School of Medicine at Mount Sinai
2015-2024
Women & Infants Hospital of Rhode Island
2013-2024
Tisch Cancer Institute
2013-2024
Tisch Hospital
2014-2024
Mount Sinai Medical Center
2010-2024
Sema4 (United States)
2020-2024
Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia term infants with encephalopathy uncertain. We conducted a randomized trial gestational age at least 36 weeks who were admitted to hospital or before six hours either severe acidosis perinatal complications resuscitation birth had moderate encephalopathy. Infants randomly assigned usual care (control group) whole-body cooling an esophageal temperature 33.5...
Objective. Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence late-onset sepsis, risk factors for disease, and impact on subsequent hospital course, we evaluated a cohort 6956 VLBW (401–1500 g) neonates admitted to clinical centers National Institute Child Health Human Development Neonatal Research Network over 2-year period (1998–2000). Methods. The maintains prospective registry all...
There are no robust data on prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (RCC) treated vascular endothelial growth factor (VEGF) -targeted therapy.Baseline characteristics and outcomes 645 anti-VEGF therapy-naïve RCC were collected from three US four Canadian cancer centers. Cox proportional hazards regression, followed by bootstrap validation, was used to identify independent OS.The median OS the whole cohort 22 months (95% CI, 20.2 26.5...
Objectives. To determine the mortality and morbidity for infants weighing 401 to 1500 g (very low birth weight [VLBW]) at by gestational age, weight, gender. Study Design. Perinatal data were collected prospectively on an inborn cohort from January 1995 through December 1996 14 participating centers of National Institute Child Health Human Development Neonatal Research Network compared with corresponding previous reports. Sociodemographic factors, perinatal events, neonatal course 120 days...
Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 NCT03085888) assessed the performance of targeted methylation analysis circulating cell-free DNA (cfDNA) to detect localize multiple types across all stages high specificity.
PURPOSE: Prostate-specific antigen (PSA) is a glycoprotein that found almost exclusively in normal and neoplastic prostate cells. For patients with metastatic disease, changes PSA will often antedate bone scan. Furthermore, many but not all investigators have observed an association between decline levels of 50% or greater survival. Since the majority phase II clinical trials for androgen-independent cancer (AIPC) used as marker, we believed it was important to agree on definitions values...
Background. The interpretation of growth rates for very low birth weight infants is obscured by limited data, recent changes in perinatal care, and the uncertain effects multiple therapies. Objectives. To develop contemporary postnatal curves preterm to relate velocity weight, nutritional practices, fetal status (small- or appropriate-for-gestational-age), major neonatal morbidities (chronic lung disease, nosocomial infection late-onset infection, severe intraventricular hemorrhage,...
It is uncertain whether the rates and causes of early-onset sepsis (that occurring within 72 hours after birth) among very-low-birth-weight infants have changed in recent years, since antibiotics begun to be used more widely during labor delivery.
Objective. We evaluated the efficacy of probiotics in reducing incidence and severity necrotizing enterocolitis (NEC) very low birth weight (VLBW) infants. Patients Methods. A prospective, masked, randomized control trial was conducted to evaluate beneficial effects NEC among VLBW (<1500 g) infants who started fed enterally survived beyond seventh day after were eligible for trial. They into 2 groups parental informed consents obtained. The study group with Infloran (Lactobacillus...
BACKGROUND. Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported. METHODS. Data were collected prospectively neonates born at <1000 g National Institute of Child Health Human Development-sponsored Research Network sites between September 1, 1998, December 31, 2001. Uniform evaluations, including assessments mental motor development the Bayley Scales Infant Development...
In advanced prostate cancer (APC), successful drug development as well advances in imaging and molecular characterisation have resulted multiple areas where there is lack of evidence or low level evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some these topics. To present the report APCCC 2017. Ten important controversy APC management were identified: high-risk localised locally cancer; “oligometastatic” castration-naïve castration-resistant role APC;...
Objectives. In the era before widespread use of inhaled nitric oxide, to determine prevalence persistent pulmonary hypertension (PPHN) in a multicenter cohort, demographic descriptors population, treatments used, outcomes those treatments, and variation practice among centers. Study Design. A total 385 neonates who received ≥50% inspired oxygen and/or mechanical ventilation had documented evidence PPHN (2D echocardiogram or preductal postductal difference) were tracked from admission at 12...
Vitamin A supplementation may reduce the risk of chronic lung disease and sepsis in extremely-low-birth-weight infants. The results our pilot study suggested that a dose 5000 IU administered intramuscularly three times per week for four weeks was more effective than lower doses given past trials.
Early administration of high doses dexamethasone may reduce the risk chronic lung disease in premature infants but can cause complications. Whether moderate would be as effective safer is not known.
Abstract BACKGROUND The majority of the prostatic cancers are adenocarcinomas characterized by glandular formation and expression luminal differentiation markers androgen receptor (AR) prostate‐specific antigen (PSA). Most indolent androgen‐dependent. Hormonal therapy that inhibits AR signaling produces symptomatic relief in patients with advanced metastatic adenocarcinomas. Prostatic small cell neuroendocrine carcinoma (SCNC) is a variant form prostate cancer (PC). In contrast to...
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear hormone that plays key role in the differentiation of adipocytes. Activation this liposarcomas and breast colon cancer cells also induces cell growth inhibition differentiation. In present study, we show PPARγ expressed human prostate adenocarcinomas lines derived from these tumors. with specific ligands exerts an inhibitory effect on lines. Further, do not have intragenic mutations gene, although 40% informative tumors...
Septicemia is a major antecedent of morbidity and mortality in very low birth weight (501- to 1500-g) infants. Our purpose was determine prospectively the incidence, clinical presentation, laboratory features, risk factors, associated with late onset septicemia infants 501 1500 g.Clinical data were collected for 2416 enrolled multicenter trial efficacy intravenous immunoglobulin preventing nosocomial infections. confirmed by positive blood culture 395 symptomatic Multivariate analyses...
OBJECTIVE. This study compared the effects of immediate (ICC) and delayed (DCC) cord clamping on very low birth weight (VLBW) infants 2 primary variables: bronchopulmonary dysplasia (BPD) suspected necrotizing enterocolitis (SNEC). Other outcome variables were late-onset sepsis (LOS) intraventricular hemorrhage (IVH). STUDY DESIGN. was a randomized, controlled unmasked trial in which women labor with singleton fetuses <32 weeks’ gestation randomly assigned to ICC (cord clamped at 5–10...
Objectives. Parenchymal involvement of intraventricular hemorrhage (IVH) is a major risk factor for neurodevelopmental handicap in very low birth weight neonates. Previous trials have suggested that indomethacin would lower the incidence and severity IVH Methods. We enrolled 431 neonates 600- to 1250-g with no evidence at 6 11 hours age prospective, randomized, placebo-controlled trial test hypothesis low-dose (0.1 mg/kg intravenously 12 postnatal every 24 two more doses) IVH. Serial cranial...