A5004802831- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and biosynthesis
- RNA Research and Splicing
- FOXO transcription factor regulation
- Inflammatory mediators and NSAID effects
- Retinoids in leukemia and cellular processes
- Cardiovascular Disease and Adiposity
- Heat shock proteins research
- Cancer-related gene regulation
- Exercise and Physiological Responses
- Cancer-related Molecular Pathways
- 14-3-3 protein interactions
- Bone and Joint Diseases
- Prostate Cancer Treatment and Research
- Genetics, Aging, and Longevity in Model Organisms
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
New York University
2018-2025
Shanghai University
2020
National Institute of Diabetes and Digestive and Kidney Diseases
2009-2018
National Institutes of Health
2008-2018
Institut thématique Génétique, génomique et bioinformatique
2014-2015
National Institute of Neurological Disorders and Stroke
2011
TU Dresden
2006
Dana-Farber Cancer Institute
1994-2005
Harvard University
1995-2005
Brigham and Women's Hospital
1997-2005
Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated receptor γ (PPARγ), drive MSCs to either osteoblasts or adipocytes, respectively. How these two factors regulated in order specify alternate fates remains pivotal question. Here we report 14-3-3–binding protein, TAZ (transcriptional coactivator with PDZ-binding motif), coactivates Runx2-dependent gene while...
Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not carcinomas, the most common human cancers. Here, we report t(2;3)(q13;p25), a translocation identified subset of thyroid follicular results DNA binding domains transcription factor PAX8 to A F peroxisome proliferator–activated receptor (PPAR) γ1. PAX8-PPARγ1 mRNA protein were detected 5 8 carcinomas 20 adenomas, 10 papillary or multinodular hyperplasias....
The ability to regulate specific genes of energy metabolism in response fasting and feeding is an important adaptation allowing survival intermittent food supplies. However, little known about transcription factors involved such responses higher organisms. We show here that gene expression adipose tissue for adipocyte determination differentiation dependent factor (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix has dual DNA-binding specificity, reduced...
Induction of terminal differentiation represents a promising therapeutic approach to certain human malignancies. The peroxisome proliferator-activated receptor γ (PPARγ) and the retinoid X α (RXRα) form heterodimeric complex that functions as central regulator adipocyte differentiation. Natural synthetic ligands for both receptors have been identified. We demonstrate here PPARγ is expressed at high levels in each major histologic types liposarcoma. Moreover, primary liposarcoma cells can be...
Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro . Because status is predictive clinical outcomes, modulation a tumor may favorably impact behavior. We conducted trial treatment patients with advanced by using ligand troglitazone, which extensive correlative laboratory studies were performed. report here results three intermediate high-grade...
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear hormone that plays key role in the differentiation of adipocytes. Activation this liposarcomas and breast colon cancer cells also induces cell growth inhibition differentiation. In present study, we show PPARγ expressed human prostate adenocarcinomas lines derived from these tumors. with specific ligands exerts an inhibitory effect on lines. Further, do not have intragenic mutations gene, although 40% informative tumors...
The nuclear hormone receptor peroxisome proliferator-activated (PPAR) gamma is a ligand-activated transcription factor that regulates several crucial biological processes such as adipogenesis, glucose homeostasis, and cell growth. It also the functional for new class of insulin-sensitizing drugs, thiazolidinediones, now widely used in treatment type 2 diabetes mellitus. Here we report PPARgamma protein levels are significantly reduced adipose cells fibroblasts response to specific ligands...
Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice have raised concerns about the role colon cancer. To analyze critically this receptor, we used heterozygous Ppar γ with both chemical genetic models malignancy. Heterozygous loss causes an β-catenin...
Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear that key regulator of adipogenesis and present in two isoforms generated by alternative splicing, PPARγ1 PPARγ2. Studies the ability each isoform to stimulate fat differentiation have yielded ambiguous results, part because PPARγ stimulates its own expression. We thus undertaken formal genetic analysis using PPARγ-null fibroblast cell lines assess specific role individual adipogenesis. show here both PPARγ2 intrinsic robust...
The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates adipogenesis, lipid metabolism, and glucose homeostasis, roles have emerged for this in the pathogenesis treatment of diabetes, atherosclerosis, cancer. We report here that induction PPARgamma activator adipogenesis forced by overexpression adipogenic regulatory proteins is blocked upon expression dominant-negative BRG1 or hBRM, ATPase subunits distinct SWI/SNF chromatin-remodeling enzymes. demonstrate histone...
Brown adipose tissue (BAT) found by positron emission/computed tomography (PET-CT) using flouro-deoxyglucose (FDG) is inducible cold exposure in men. Factors leading to increased BAT are of great interest for its potential role the treatment diabetes and obesity.We tested whether thyroid hormone (TH) levels related volume activity a patient with mutation insulin receptor gene. DESIGN/SETTING/INTERVENTION: Our work was based on case report an observational study at National Institutes...
Abstract BACKGROUND The objective of this study was to assess the biologic activity rosiglitazone, a peroxisome proliferator‐activated receptor γ agonist that has been approved treat type 2 diabetes, in men with recurrent prostate carcinoma using change specific antigen (PSA) doubling time (PSADT) as primary outcome variable. METHODS Men histologically confirmed carcinoma, no recent hormone therapy, rising serum PSA level after radical prostatectomy and/or radiation and radiographic evidence...
Mitochondria and peroxisomes execute some analogous, nonredundant functions including fatty acid oxidation detoxification of reactive oxygen species, and, in response to select metabolic cues, undergo rapid remodeling division. Although these organelles share components their division machinery, it is not known whether a common regulator coordinates biogenesis. Here we show that thermogenic stimuli, brown fat tissue (BAT) selective expand number demonstrate ectopic expression the...
Zinc finger proteins constitute the largest family of transcription regulators in eukaryotes. These factors are involved diverse processes many tissues, including development and differentiation. We report here characterization zinc protein ZNF638 as a novel regulator adipogenesis. is induced early during adipocyte Ectopic expression increases adipogenesis vitro, whereas its knockdown inhibits differentiation decreases adipocyte-specific genes. physically interacts transcriptionally...
PPARγ is a dominant regulator of fat cell differentiation. However, this nuclear receptor also plays an important role in the differentiation intestinal and other epithelial types. The mechanism by which can influence such diverse lineages unknown. We show here that interacts with Hic-5, coactivator protein expressed gut cells. Hic-5 colocalize to villus epithelium small intestine, their expression during embryonic development correlates transition from endoderm specialized epithelium; both...