A5056139436- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Muscle metabolism and nutrition
- Complement system in diseases
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- Advanced Fluorescence Microscopy Techniques
- Ubiquitin and proteasome pathways
- Renal Diseases and Glomerulopathies
- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Parathyroid Disorders and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- Pancreatic function and diabetes
- Exercise and Physiological Responses
- Skin Protection and Aging
- Physiological and biochemical adaptations
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Telomeres, Telomerase, and Senescence
New York University
2019-2025
CY Cergy Paris Université
2024
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires
2024
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2022-2023
Université de Limoges
2016-2018
Abstract Aging leads to a number of disorders caused by cellular senescence, tissue damage, and organ dysfunction. It has been reported that anti‐inflammatory insulin‐sensitizing compounds delay, or reverse, the aging process prevent metabolic disorders, neurodegenerative disease, muscle atrophy, improving healthspan extending lifespan. Here we investigated effects PPARγ agonists in preventing increasing longevity, given their known properties lowering inflammation decreasing glycemia. Our...
Abstract Fibroblast growth factor 23 (FGF23) is a bone-secreted protein widely recognized as critical regulator of skeletal and mineral metabolism. However, little known about the nonskeletal production FGF23 its role in tissues other than bone. Growing evidence indicates that circulating levels rise with high-fat diet (HFD) they are positively correlated body mass index (BMI) humans. In present study, we show for first time increased obese humans correlate expression adipose Fgf23 both BMI....
Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control this network by microRNAs remains incompletely understood. MiR-33 critically regulates genes involved in metabolic pathways, including cholesterol efflux, reverse transport, fatty acid oxidation, autophagy. Given its role homeostasis, we investigated whether miR-33 participates the regulation BAT activity, white beiging, adaptive...
Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat and oxidative proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism fat tissues; however, whether is differentially expressed adipose depots how its levels are regulated tissues remain unclear. Here, we show that higher brown subcutaneous than those visceral depot more abundant differentiated, thermogenic adipocytes. Gene expression...
GASP-2 is a secreted multi-domain glycoprotein known as specific inhibitor of myostatin and GDF-11. Here we investigate the role on myogenesis effect its glycosylation activity.GASP-2 overexpression or knockdown by shRNAs were carried out C2C12 myoblasts cells. In silico analysis protein was performed to identify sites. We produced mouse recombinant in prokaryotic system obtain fully deglycosylated allowing us study importance this post-translational modification activity.Both mature...
Overexpression of Gasp-1, an inhibitor myostatin, leads to a hypermuscular phenotype due hypertrophy rather than hyperplasia in mice. However date, the cellular and molecular mechanisms underlying this are not investigated.Skeletal muscles overexpressing Gasp-1 mice, called Tg(Gasp-1) were analyzed by histological methods. Satellite cell-derived myoblasts from these mice used investigate mechanisms.We demonstrated that was related myonuclear accretion during first 3 postnatal weeks...
Purpose Polymorphisms in complement genes are risk-associated for age-related macular degeneration (AMD). Functional analysis revealed a common deficiency to control the alternative pathway by gene polymorphisms. Thus, we investigated levels of terminal complex (TCC) plasma wet AMD patients with defined genotypes and impact activation their on second-messenger signaling, expression, cytokine/chemokine secretion retinal pigment epithelium (RPE) cells. Design Collection from (n = 87: 62%...
Background/Aims: Myostatin is known as a powerful negative regulator of muscle growth playing key role in skeletal homeostasis. Recent studies revealed that myostatin-deficient mice lead to an increase insulin sensitivity, decrease adiposity and resistance obesity, showing myostatin can also impact on metabolism. Thus, appeared potential therapeutic target treat resistance. Methods: We generated transgenic overexpressing Gasp-1, inhibitor. Results: Surprisingly, we found these gained weight...
Abstract Zinc finger factors are implicated in a variety of cellular processes, including adipose tissue differentiation and thermogenesis. We have previously demonstrated that zinc protein 638 (ZNF638) is transcriptional coactivator acting as an early regulator adipogenesis vitro. In this study, we show, to our knowledge for the first time, that, vivo, ZNF638 abounds selectively mature brown subcutaneous fat tissues fully differentiated thermogenic adipocytes. Furthermore, gene expression...
Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis due to its well-known anti-inflammatory role in immune cells but impact on brown and beige adipose tissue biology has not yet been investigated. Here, we present novel evidence that MTX increases gene expression thermogenic genes tissues a fat cell autonomous manner. Furthermore, show mice with associated cold resistance, improved glucose homeostasis, decreased inflammation, reduced hepatosteatosis high-fat diet...
Forkhead box transcription factors have been shown to be involved in various developmental and differentiation processes. In particular, members of the FoxP family previously characterized depth for their participation regulation lung neuronal cell T-cell development function; however, role adipocyte functionality has not yet investigated. Here, we report first time that P4 (FoxP4) is expressed at high levels subcutaneous fat depots mature thermogenic adipocytes. Through molecular gene...
Since the re-classification of membranoproliferative glomerulonephritis new disease entity C3 glomerulopathy is diagnosed if deposition clearly dominant over immunoglobulins in immunohistochemistry or immunofluorescence. Although this definition more orientated at pathophysiology as mediated by activity alternative complement pathway remains a heterogenous group disorders. Genetic autoimmune causes are associated several but not all patients with disease. However, prognosis poorly...