A5046961180- Skin Protection and Aging
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Cellular Mechanics and Interactions
- Ion Channels and Receptors
- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- Air Quality and Health Impacts
- Caveolin-1 and cellular processes
- Neonatal skin health care
- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and biosynthesis
- Collagen: Extraction and Characterization
- Nail Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Plant Surface Properties and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
Groupe Clarins (France)
2014-2024
Centre Hospitalier Victor Dupouy
2008
Abstract Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes melanocytes in the epidermis. Here we report that secreted by enhance melanin synthesis increasing both expression activity of melanosomal proteins. Furthermore, show function keratinocyte-derived is phototype-dependent modulated ultraviolet B. In sum, this study uncovers...
Sensitive skin is a clinical syndrome characterized by the occurrence of unpleasant sensations, such as pruritus, burning or pain, in response to various factors, including skincare products, water, cold, heat, other physical and/or chemical factors. Although these symptoms suggest inflammation and activation peripheral innervation, pathophysiogeny sensitive remains unknown. We systematically analysed cutaneous biopsies from 50 healthy women with non-sensitive demonstrated that...
Abstract Tissue homeostasis requires regulation of cell–cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melanocytes into cues promoting their pigmentation dendrite outgrowth, while transfer melanin pigments to convey photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we show that caveolae are asymmetrically distributed in particularly abundant at the...
Abstract The effects of air pollution on health are gaining increasing research interest with limited data skin alterations available. It was suggested that is a trigger factor for sensitive (SS). However, this based surveys lack experimental data. SS related to altered nerve endings and cutaneous neurogenic inflammation. TTe present study assess the in vitro effect particulate matter (PM) epidermis ending homeostasis. PM samples were collected according validated protocol. Reconstructed...
Aging | doi:10.18632/aging.206055. Françoise Boismal, Sandy Peltier, Sophie Ly ka so, Guillaume Chevreux, Loïse Blondel, Kévin Serror, Niclas Setterblab, Elina Zuelgaray, David Boccara, Maurice Mimoun, Christelle Guere, Armand Benssussan, Marie Dorr, Gallic Beauchef, Katell Vie, Laurence Michel
Membrane lipid raft model has long been debated, but recently the concept of submicrometric domains emerged to characterize larger (micrometric) and more stable membrane domains. Such organize signaling platforms involved in normal or pathological conditions. In this study, adhering human keratinocytes were investigated for their ability such specialized Successful fluorescent probing domains, by either inserting exogenous sphingomyelin (BODIPY-SM) using detoxified fragments lysenin theta...
Emilin-1 is a versatile protein abundant in tissues where resilience and elastic recoil are prominent interacting with components of the extracellular matrix. Still, little known about skin. Therefore, we investigated skin, its localization, fate upon ageing, interactions other proteins effect knockdown.Skin explants from young or old Caucasian women, immunofluorescently labelled by anti-Emilin-1, anti-Fibrillin-1 anti-Elastin antibodies, were analysed using confocal microscopy. Skin...
Abstract Aging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development large array age-related diseases. Evidence suggests accumulation senescent cells promotes both normal pathological aging. Oxic stress key driver cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic hypoxic transitions, we hypothesized these animals have developed specific longevity strategies...
Human skin is subject to frequent changes in ambient temperature and humidity needs cope with these environmental modifications. To decipher the molecular response of human repeated climatic change, a versatile model equivalent "hot-wet" (40°C, 80% relative [RH]) or "cold-dry" (10°C, 40% RH) stress daily was used. obtain an exhaustive view mechanisms elicited by large-scale gene expression DNA microarray analysis performed modulated function determined bioinformatic annotation. This revealed...
Summary Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete specific factors transduced by melanocytes into cues to promote their pigmentation dendrite outgrowth, while transfer melanin pigments convey photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we found that caveolae polarize in are particularly abundant at...
Visual and molecular changes occurring upon aging are rather well characterized. Still, signs show great significant inter-individual variations, little is known concerning the link between perceived age cutaneous microcirculation.To investigate this point, we recruited Caucasian women in their mid-50's to mid-70's subsampled looking older or younger than age. We studied facial skin color, as microvascular reactivity local heating assessed forearm skin. also used biopsies from some of these...