A5078485909- melanin and skin pigmentation
- Skin Protection and Aging
- Caveolin-1 and cellular processes
- Ion Channels and Receptors
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Skin and Cellular Biology Research
- RNA regulation and disease
- Tactile and Sensory Interactions
- Protein Tyrosine Phosphatases
- Cell Adhesion Molecules Research
- Olfactory and Sensory Function Studies
- Advanced Sensor and Energy Harvesting Materials
- Chemical Reactions and Isotopes
- Atherosclerosis and Cardiovascular Diseases
Groupe Clarins (France)
2014-2023
Abstract Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes melanocytes in the epidermis. Here we report that secreted by enhance melanin synthesis increasing both expression activity of melanosomal proteins. Furthermore, show function keratinocyte-derived is phototype-dependent modulated ultraviolet B. In sum, this study uncovers...
Abstract Tissue homeostasis requires regulation of cell–cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melanocytes into cues promoting their pigmentation dendrite outgrowth, while transfer melanin pigments to convey photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we show that caveolae are asymmetrically distributed in particularly abundant at the...
Emilin-1 is a versatile protein abundant in tissues where resilience and elastic recoil are prominent interacting with components of the extracellular matrix. Still, little known about skin. Therefore, we investigated skin, its localization, fate upon ageing, interactions other proteins effect knockdown.Skin explants from young or old Caucasian women, immunofluorescently labelled by anti-Emilin-1, anti-Fibrillin-1 anti-Elastin antibodies, were analysed using confocal microscopy. Skin...
Tactile sensitivity generally decreases with aging and is associated impairments in skin properties. Products that hydrate the can combat touch deficits aromatic compounds have been shown to improve mechanical Thus, we tested a base cosmetic oil against perfumed oil, applied of females aged 40-60 years, on tactile properties after repeated application. detection thresholds were assessed using calibrated monofilaments at index finger, palm, forearm, cheek. Spatial discrimination finger was...
Summary Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete specific factors transduced by melanocytes into cues to promote their pigmentation dendrite outgrowth, while transfer melanin pigments convey photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we found that caveolae polarize in are particularly abundant at...