A5042259706- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Wound Healing and Treatments
- Erythrocyte Function and Pathophysiology
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and biosynthesis
- Blood transfusion and management
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Cardiac Ischemia and Reperfusion
- Drug-Induced Adverse Reactions
- Immunodeficiency and Autoimmune Disorders
- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Blood properties and coagulation
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Cutaneous lymphoproliferative disorders research
- Cholesterol and Lipid Metabolism
- Natural Antidiabetic Agents Studies
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
Inserm
2006-2025
Université Paris Cité
2020-2025
Sorbonne Paris Cité
2025
Skin Research Center
2024
Hôpital Saint-Louis
2023-2024
Institut National de la Transfusion Sanguine
2022-2023
Innovation Plasturgie Composites
2023
Biologie Intégrée du Globule Rouge
2023
Laboratory of Excellence GR-Ex
2022
Roche (France)
2016
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this vitro process. Storage-induced microerythrocytes (SMEs) are morphologically-altered senescent RBCs that accumulate during and cleared from circulation following transfusion. However, molecular alterations trigger clearance RBC subset remain to be identified. Using a staining protocol sorts long-stored SMEs (i.e., CFSEhigh)...
Background: Long-chain polyunsaturated fatty acids (PUFAs) are important modulators of red blood cell (RBC) rheology. Dietary PUFAs readily incorporated into the RBC membrane, improving deformability, fluidity, and hydration. However, enriching lipid membrane with increases potential for peroxidation in oxidative environments (e.g., refrigerated storage), resulting damage. Substitution bis-allylic hydrogens deuterium ions decreases hydrogen abstraction, thereby inhibiting peroxidation. If is...
Healing of complex wounds requires dressings that must, at least, not hinder and should ideally promote the activity key healing cells, in particular fibroblasts. This vitro study assessed effects three wound-dressings (a pure Ca
Synthetic peptide vaccines were designed to target the neuropeptides innervating Ixodes ricinus salivary glands and hindgut they tested for their capacity afford protective immunity against nymphs or larvae Anaplasma phagocytophilum-infected nymph infestation, in mice sheep, respectively. In both models, assembly of SIFamide (SIFa) myoinhibitory (MIP) into multiple antigenic constructs (MAPs) elicited a robust IgG antibody response following immunization. Nevertheless, no observable...
To identify potential vaccine candidates against Ixodes ricinus and tick-borne pathogen transmission, we have previously sequenced the salivary gland transcriptomes of female ticks infected or not with Bartonella henselae. The hypothesized both IrSPI (I. serine protease inhibitor) IrLip1 lipocalin 1) as protective antigens decreasing tick feeding and/or transmission pathogens was based on their presumed involvement in dampening host immune response to feeding. Vaccine endpoints included...
Aging | doi:10.18632/aging.206055. Françoise Boismal, Sandy Peltier, Sophie Ly ka so, Guillaume Chevreux, Loïse Blondel, Kévin Serror, Niclas Setterblab, Elina Zuelgaray, David Boccara, Maurice Mimoun, Christelle Guere, Armand Benssussan, Marie Dorr, Gallic Beauchef, Katell Vie, Laurence Michel
Although refrigerated storage slows the metabolism of volunteer donor RBCs, cellular aging still occurs throughout this
A novel i.v. lipid preparation (MCT:FO) containing 80% medium chain-triacylglycerols and 20% fish oil was recently developed to rapidly replenish cell membrane phospholipids with omega 3 (n-3) polyunsaturated fatty acids (PUFA). In regard of this property, we investigated the effect a single administration MCT:FO on recovery cardiac function after ischemia in control n-3-depleted rats. Results were compared those obtained either preparation, where FO replaced by triolein (MCT:OO), or saline....
Long-chain polyunsaturated fatty acids (LC-PUFAs) are important modulators of red blood cell (RBC) rheology. Dietary LC-PUFAs readily incorporated into the RBC membrane, improving deformability, fluidity, and hydration. Female C57BL/6J mice consumed diets containing increasing amounts fish oil (FO) ad libitum for 8 weeks. filterability, post-transfusion recovery (PTR) were evaluated before after cold storage. Lipidomics lipid peroxidation markers in fresh stored RBCs. High-dose dietary FO...
This study aimed at determining whether glucose-insulin-potassium (GIK) solutions modify the NADH/NAD(+) ratio during postischemic reperfusion and their cardioprotective effect can be attributed to this change in part through reduction of mitochondrial reactive oxygen species (ROS) production. The hearts 72 rats were perfused with a buffer containing glucose (5.5 mM) hexanoate (0.5 mM). They maintained normoxia for 30 min then subjected low-flow ischemia (0.5% preischemic coronary flow 20...
Refrigerated storage of red cell concentrates before transfusion is associated with progressive alterations blood cells (RBC). Small RBC (type III echinocytes, sphero-echinocytes, and spherocytes) defined as storage-induced micro-erythrocytes (SME) appear during pretransfusion storage. SME accumulate variable intensity from donor to donor, are cleared rapidly after transfusion, their proportion correlates recovery. They can be objectively quantified using imaging flow cytometry (IFC)....
The present study aims mainly at exploring the effects of a severe depletion in polyunsaturated long-chain omega3 fatty acids upon fate circulating lipids. plasma concentration and acid pattern triglycerides, diglycerides, free acids, phospholipids were measured omega3-depleted control rats injected intravenously one hour before sacrifice with either saline, medium-chain triglyceride:olive oil emulsion or triglyceride:fish recently found to rapidly increase phospholipid content C20:5omega3...
Abstract Background/Introduction Hypercholesterolemia is a major risk factor for cardiovascular diseases. Some polyphenols have shown promising potential in modulating circulating cholesterol. The polyphenol-rich active substance TOTUM-070 (T070) blend of five plant extracts that previously demonstrated beneficial effects preclinical models, and subjects with moderate hypercholesterolemia when used at 5g/day 12 weeks (the HEART study NCT04760951). Purpose OLALIP an open-label, single-centre,...
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a recently discovered autoinflammatory disorder linked to somatic mutations in the UBA1 gene, resulting profound cytoplasm-restricted defect ubiquitylation. The disease characterized by macrocytic anemia that remains poorly understood. To investigate erythroid lineage VEXAS, we conducted comprehensive study combining vivo assessments of patients’ mature red cells and marrow erythroblasts, alongside vitro...
There is a significant need for highly effective vaccines against emerging and common veterinary infectious diseases. Canine adenovirus type 2 (CAV2) vectors allow rapid development of multiple have demonstrated their potential in animal models. In this study, we compared the immunogenicity non-replicating CAV2 vector encoding rabies virus glycoprotein with without MontanideTM ISA 201 VG, an oil-based adjuvant. All vaccinated mice rapidly achieved seroconversion, which was associated...