A5085682671- Blood groups and transfusion
- Blood transfusion and management
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Neonatal Health and Biochemistry
- Genetics and Neurodevelopmental Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurobiology and Insect Physiology Research
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Neurosurgical Procedures and Complications
- Mosquito-borne diseases and control
- Suicide and Self-Harm Studies
- Circadian rhythm and melatonin
- Hemoglobinopathies and Related Disorders
- Invertebrate Immune Response Mechanisms
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Blood donation and transfusion practices
- Substance Abuse Treatment and Outcomes
- Autism Spectrum Disorder Research
Columbia University Irving Medical Center
2015-2024
Columbia University
2005-2024
Newark Beth Israel Medical Center
2020-2024
Johns Hopkins University
2024
New York Hospital Queens
2022-2023
NewYork–Presbyterian Hospital
2022-2023
New York Blood Center
2020
Harlem Hospital Center
2016
Shrewsbury College
2015
Rockefeller University
2009-2011
Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage is accumulation free cholesterol (FC) the ER, leading to activation unfolded protein response (UPR) C/EBP homologous (CHOP)–induced apoptosis. Here we show that p38 MAPK signaling necessary for CHOP induction Additionally, two other pathways must cooperate with p38-CHOP effect One involves type scavenger receptor (SRA). As evidence, FC loading by non-SRA mechanisms...
BACKGROUNDAlthough convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited.METHODSWe conducted a randomized, double-blind, trial among adults hospitalized with and critical COVID-19 at 5 sites in New York City (USA) Rio de Janeiro (Brazil). Patients were 2:1 receive single transfusion of either or normal control plasma. The primary outcome was clinical status 28 days following...
The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X retardation syndrome result from loss function RNA-binding protein FMRP. disease is usually caused by a triplet repeat expansion in 5'UTR FMR1 gene. This leads to through transcriptional gene silencing, pointing key for FMRP, but precluding genetic identification critical activities within protein. Moreover, antisense transcripts (FMR4, ASFMR1) same locus have been reported be silenced...
Survival of bacterial infection is the result complex host-pathogen interactions. An often-overlooked aspect these interactions circadian state host. Previously, we demonstrated that Drosophila mutants lacking regulatory proteins Timeless (Tim) and Period (Per) are sensitive to by S. pneumoniae. Sensitivity can be mediated either changes in resistance (control microbial load) or tolerance (endurance pathogenic effects infection). Here show Tim regulates against both pneumoniae marcescens. We...
Summary: Condom failure (slippage or breakage) has been shown to be associated with HIV seroconversion among men who have sex (MSM), but predictors of poorly elucidated. Of 2592 HIV-seronegative MSM participants in the Network for Prevention Trials (HIVNET) multisite Vaccine Preparedness Study reported condom use anal 6 months before enrollment, was by 16.6%. rates 2.1/100 episodes usage (2.5 failures/100 receptive and 1.9/100 insertive sex). In separate multivariate models evaluating...
Fragile X syndrome, the most common known monogenic cause of autism, results from loss FMR1, a conserved, ubiquitously expressed RNA-binding protein. Recent evidence suggests that syndrome and other types autism are associated with immune system defects. We found Drosophila melanogaster Fmr1 mutants exhibit increased sensitivity to bacterial infection decreased phagocytosis bacteria by systemic cells. Using tissue-specific RNAi-mediated knockdown, we showed plays cell-autonomous role in...
Abstract Background Although convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited. Objective To evaluate the clinical and safety of among adults hospitalized with critical COVID-19. Design Randomized, double-blind, controlled, multicenter, phase 2 trial conducted April 21 st November 27 th , 2020. Setting Five hospitals in New York City (NY, USA) Rio de Janeiro (Brazil)....
Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%). Its prevalence hypothesized to be due conferring resistance malaria. However, G6PD deficiency also results hemolytic sequelae from oxidant stress. Moreover, associated with kidney disease, diabetes, pulmonary hypertension, immunological defects, and neurodegenerative diseases. To date, only available mouse models have decreased levels...
Background: Long-chain polyunsaturated fatty acids (PUFAs) are important modulators of red blood cell (RBC) rheology. Dietary PUFAs readily incorporated into the RBC membrane, improving deformability, fluidity, and hydration. However, enriching lipid membrane with increases potential for peroxidation in oxidative environments (e.g., refrigerated storage), resulting damage. Substitution bis-allylic hydrogens deuterium ions decreases hydrogen abstraction, thereby inhibiting peroxidation. If is...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. G6PD an essential enzyme pentose phosphate pathway (PPP), generating NADPH needed for cellular biosynthesis and reactive oxygen species (ROS) homeostasis, latter especially key red blood cells (RBCs). Beyond RBC, there emerging evidence that exerts immunologic role by virtue of its functions leukocyte oxidative metabolism anabolic synthesis necessary immune effector function. We review these here,...
Two non-twin sisters issued from healthy non-consanguineous parents of normal stature demonstrated severe growth failure, hypoglycemia, and evidence deficiency hormone, thyroid stimulating hormone (TSH), adrenocorticotropic (ACTH); in addition, they both had a very small sella turcica located sphenoid bone abnormal morphology. This form familial pituitary dwarfism is different the genetic forms previously described.
Abstract Background and Objectives Platelet transfusions are increasing with medical advances. Based on FDA criteria, platelet units assessed by in vitro measures; however, it is not known how processing storage duration affect function vivo. Our study's aim was to develop a novel transfusion model stored mouse plasma that meets criteria adapted mice, transfused fresh platelets detectable clots Study Design Methods were prepared using modified platelet‐rich (PRP) collection protocol....
Long-chain polyunsaturated fatty acids (LC-PUFAs) are important modulators of red blood cell (RBC) rheology. Dietary LC-PUFAs readily incorporated into the RBC membrane, improving deformability, fluidity, and hydration. Female C57BL/6J mice consumed diets containing increasing amounts fish oil (FO) ad libitum for 8 weeks. filterability, post-transfusion recovery (PTR) were evaluated before after cold storage. Lipidomics lipid peroxidation markers in fresh stored RBCs. High-dose dietary FO...
Key words: calcification; mitral valve; dialysis was diagnosed in 1980 and complicated by hypertension which had been well controlled.Continuous ambulatory peroitoneal commenced 1994, at time her serum calcium 2.36 mmol/l
ABSTRACT Aims To evaluate the ability of a hand‐held breath analyser, Zenalyser ® (Zenics Medical), to identify alcohol‐dependent patients receiving disulfiram therapy and assess sensitivity specificity instrument at different time intervals post‐disulfiram dosing. Design Breath samples were taken from two groups patients, one group on daily regimen no disulfiram. The analysed for combined concentration carbon disulphide acetone produced metabolism From these data, reference ranges prepared...
Two children with multiple severe disabilities due to brain destruction by neonatal infection had recurrent hypothermia (<34°C) associated thrombocytopenia (<50,000), and clinical hemorrhage. They also milder, less consistent erythroid myeloid cell line abnormalities. The was presumed be hypothalamic dysfunction. Rewarming always followed correction of hematologic problems, but normal temperature difficult maintain. Recognition this entity may improve long-term management some severely...