A5076180587- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- FinTech, Crowdfunding, Digital Finance
- Endometriosis Research and Treatment
- Sleep and Wakefulness Research
- LGBTQ Health, Identity, and Policy
- Plant Molecular Biology Research
- Genetics and Neurodevelopmental Disorders
- Reproductive Health and Technologies
- Social Media in Health Education
- Autism Spectrum Disorder Research
- Palliative Care and End-of-Life Issues
- Sexuality, Behavior, and Technology
- RNA Interference and Gene Delivery
- Economic and Financial Impacts of Cancer
- PI3K/AKT/mTOR signaling in cancer
- Sexual function and dysfunction studies
- Childhood Cancer Survivors' Quality of Life
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Invertebrate Immune Response Mechanisms
- Gender Politics and Representation
Cedars-Sinai Medical Center
2022-2024
Columbia University Irving Medical Center
2015-2023
Although sleep appears to be broadly conserved in animals, the physiological functions of remain unclear. In this study, we sought identify a defect common diverse group short-sleeping Drosophila mutants, which might provide insight into function and regulation sleep. We found that these mutants share phenotype sensitivity acute oxidative stress, exhibiting shorter survival times than controls. further showed increasing wild-type flies using genetic or pharmacological approaches increases...
In Drosophila, ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these secrete the neuropeptide Pdf and have been called ‘master pacemakers’ because they are essential for rhythms. A subset Pdf+ (the morning oscillator) regulates activity communicates with other non-Pdf+ neurons, including a evening oscillator. It has assumed that in is required functions. To test this, we developed validated Gal4-UAS based CRISPR tools cell-specific disruption key...
Fragile X syndrome, the most common known monogenic cause of autism, results from loss FMR1, a conserved, ubiquitously expressed RNA-binding protein. Recent evidence suggests that syndrome and other types autism are associated with immune system defects. We found Drosophila melanogaster Fmr1 mutants exhibit increased sensitivity to bacterial infection decreased phagocytosis bacteria by systemic cells. Using tissue-specific RNAi-mediated knockdown, we showed plays cell-autonomous role in...
Inhibitors of enzymes that inactivate amine neurotransmitters (dopamine, serotonin), such as catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), are thought to increase neurotransmitter levels widely used treat Parkinson's disease psychiatric disorders, yet the role these in regulating behavior remains unclear. Here, we investigated genetic loss a similar enzyme model organism Drosophila melanogaster. Because Ebony modifies inactivates neurotransmitters, its is assumed levels,...
Testosterone is commonly used as gender-affirming therapy to induce masculinization in transmasculine individuals. The effects of testosterone on endometrial tissue are complex, and while some patients experience atrophy taking testosterone, others do not. Reports gynecologic malignancies, cancer particular, extremely rare (Urban et al., May 2011, Jeevananthan Iyengar, 2021, Agnieszka Bobola, 2021). Here we report a case intraepithelial neoplasia transgender man testosterone.
Abstract In Drosophila , ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these secrete the neuropeptide Pdf and have been called “master pacemakers” because they are essential for rhythms. A subset + (the morning oscillator) regulates activity communicates with other non-Pdf neurons, including a evening oscillator. It is assumed that in required functions. To test this, we developed validated Gal4-UAS based CRISPR tools cell-specific disruption key...
To evaluate the patterns of inpatient (IP) vs outpatient (OP) initiation palliative care (PC) with a focus on primary language and factors associated successful IP to OP PC transition in gynecological cancer patients. Patients were identified by ICD10 codes first note between 01/2017 12/2021. excluded for incomplete data referral non-cancer related reasons. Baseline characteristics including social demographics, hospitalization outcomes reasons obtained. was assessed cohort. Statistical...
To describe the unmet needs disclosed by patients crowdfunding for gynecologic cancer care and to draw comparisons between with cervical, uterine, ovarian cancer. Crowdfunding refers solicitation of donations, typically using internet, from a community specific cause. We queried public forum GoFundMe.com "cervical cancer," "uterine "ovarian cancer." The first 50 posts identified on single day each disease type fundraising within US were analyzed. Data campaign goals expressed manually...