A5090267635- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Trauma and Emergency Care Studies
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Retinal Imaging and Analysis
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare Policy and Management
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Neonatal and fetal brain pathology
- Neurobiology and Insect Physiology Research
- COVID-19 Impact on Reproduction
- Pediatric Urology and Nephrology Studies
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Cerebrospinal fluid and hydrocephalus
- Retinal and Optic Conditions
- Genetics and Neurodevelopmental Disorders
- Pregnancy and preeclampsia studies
- Neuroscience of respiration and sleep
- Glaucoma and retinal disorders
- Prenatal Substance Exposure Effects
- Circadian rhythm and melatonin
Pennsylvania Hospital
2024
University of Pennsylvania
2021
Oregon Health & Science University
2018-2020
Columbia University
2017
Columbia University Irving Medical Center
2015
Fragile X syndrome, the most common known monogenic cause of autism, results from loss FMR1, a conserved, ubiquitously expressed RNA-binding protein. Recent evidence suggests that syndrome and other types autism are associated with immune system defects. We found Drosophila melanogaster Fmr1 mutants exhibit increased sensitivity to bacterial infection decreased phagocytosis bacteria by systemic cells. Using tissue-specific RNAi-mediated knockdown, we showed plays cell-autonomous role in...
Spectral-domain optical coherence tomography (SD-OCT) is an accessible clinical tool for measuring structural changes to the retina, and increasingly as a biomarker brain-predominant neurodegenerative diseases like Alzheimer's. Information about retinal function can also be extracted from OCT images, but under-studied, with literature examples often employing challenging protocols or requiring specialized hardware. The first goal of this study was verify that functional imaging feasible...
Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes. However, steroid administration in setting a viral respiratory infection can worsen maternal Therefore, decision administer must balance benefits with potential harm mother if she is infected novel coronavirus disease 2019 (COVID-19). This study aimed determine gestational ages for which administering antenatal women at high labor concurrent COVID-19 results improved combined and infant
While antenatal corticosteroids are routinely used to decrease adverse neonatal outcomes following preterm delivery, also associated with worse in patients viral respiratory infections. Currently the setting of COVID-19 pandemic, it is unclear whether for infant benefit outweigh potential harm a pregnant woman infection.To determine at which gestational ages administering optimal management strategy hospitalized women prelabor rupture membranes (PPROM) who have infection.We designed...
OBJECTIVE: To evaluate the cost effectiveness of three different approaches to care neonates born at 22 weeks gestation: universal resuscitation, selective or no resuscitation. METHODS: We constructed a decision-analytic model using TreeAge compare outcomes death and survival with without neurodevelopmental impairment in theoretical cohort 5,176 (an estimate annual number deliveries that occur 22nd week gestation United States). took societal perspective lifetime horizon, all costs were...
Objective Previous studies have identified an association between obstetric interventions and the time of day in which they are performed; however, do not account for granular variations temporality delivery interventions, is influenced by both health care providers resource availability. We sought to assess differences birth among spontaneous vaginal births (SVBs) versus operative (forceps- vacuum-assisted) (OVBs). Study Design This cross-sectional study used certificate data from National...
This study seeks to determine the cost effectiveness of elective induction labor at 38 weeks for low-risk nulliparous women compared with expectant management in setting COVID-19 pandemic. A cost-effectiveness analysis model was built using TreeAge Pro 2020 software inputs derived from literature. We maternal and neonatal outcomes costs associated Maternal included hypertensive disorders pregnancy, mode delivery, hospitalization or intensive care unit admission infection death. Neonatal...
INTRODUCTION: With the rising opioid epidemic, literature has explored effect of maintenance therapies and detoxification in opioid-dependent pregnancy. However, outcomes pregnancy remit population have not yet been ascertained. This study will examine remission on maternal fetal compared to a general population. METHODS: A retrospective cohort 1,853,219 singleton gestations California women with data. Maternal comprised cesarean deliveries, placental abruption, postpartum hemorrhage,...
April 22, 2018April 10, 2018Free AccessQuantifying Retinal Layers in CASPR2 Antibody Syndrome with Optical Coherence Tomography (OCT) (P1.350)Clarice Zhou, BS, Vy Le, BA, Marissa Kellogg, MD, MPH, and Jacqueline Bernard, FAANAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P1.350 Letters to the Editor
INTRODUCTION: In women who desire resuscitation of a periviable neonate, cesarean delivery is commonly used for the usual indications. The objective this study was to examine impact mode 22-week neonate on current and future pregnancies. METHODS: Decision-analytic model constructed using TreeAge software compare outcomes method at 22 gestational age in theoretical cohort 5,200 pregnant women. interventions compared are with classical incision versus vaginal pregnancies where neonatal efforts...