A5102773192- Human Mobility and Location-Based Analysis
- Urban Transport and Accessibility
- Microbial Natural Products and Biosynthesis
- Single-cell and spatial transcriptomics
- Transportation Planning and Optimization
- Fungal Biology and Applications
- Traffic Prediction and Management Techniques
- Smart Parking Systems Research
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- CRISPR and Genetic Engineering
- Geochemistry and Elemental Analysis
- Retinal Development and Disorders
- Congenital heart defects research
- T-cell and B-cell Immunology
- Groundwater and Isotope Geochemistry
- Topic Modeling
- Coronary Artery Anomalies
- Insect and Pesticide Research
- Congenital Heart Disease Studies
- Genetics and Neurodevelopmental Disorders
- Sphingolipid Metabolism and Signaling
- Complex Network Analysis Techniques
- RNA and protein synthesis mechanisms
Genomic Health (United States)
2024
New York University
2015-2024
University of California, Los Angeles
2024
University of Washington
2010-2023
Harvard University
2023
Massachusetts General Hospital
2023
California Institute of Technology
2020-2022
Washington University in St. Louis
2021
Dana-Farber Cancer Institute
2020
Group Health Cooperative
2020
The last decade has witnessed very active development in two broad, but separate fields, both involving understanding and modeling of how individuals move time space (hereafter called "travel behavior analysis" or "human mobility analysis"). One field comprises transportation researchers who have been working the for decades other involves new comers from a wide range disciplines, primarily computer scientists physicists. Researchers these fields work with different datasets, apply...
Abstract This study evaluates ten commercially available single-cell RNA sequencing (scRNA-seq) approaches across four technology groups: Emulsion-based kits from 10x Genomics and Fluent Biosciences; Microwell-based Becton Dickinson, Honeycomb Technologies Singerlon Technologies; Combinatorial-indexing Parse Biosciences Scale a Matrigel-based kit Scipio Biosciences. Peripheral blood mononuclear cells (PBMCs) single donor were used to assess analytical performance. Key features such as sample...
Transformer models are revolutionizing machine learning, but their inner workings remain mysterious. In this work, we present a new visualization technique designed to help researchers understand the self-attention mechanism in transformers that allows these learn rich, contextual relationships between elements of sequence. The main idea behind our method is visualize joint embedding query and key vectors used by transformer compute attention. Unlike previous attention techniques, approach...
Arsenic, a toxic metalloid, is commonly associated with sulfide minerals in anoxic sediments. Here we characterize arsenic(III) retention on sediments from sulfidic estuarine marsh using series of sorption experiments, and probe the structure retained arsenite X-ray absorption spectroscopy. Although extent varied sampling locations, several adsorption characteristics were apparent. A fraction adsorbed over entire pH range examined, although it was most extensive at greater than 7, conformed...
Structural protein 4.1, which has crucial interactions within the spectrin–actin lattice of human red cell membrane skeleton, also is widely distributed at diverse intracellular sites in nucleated cells. We previously showed that 4.1 essential for assembly functional nuclei vitro and capacity to bind actin required. Here we report colocalize mammalian using fluorescence microscopy and, by higher-resolution detergent-extracted whole-mount electron microscopy, are associated on nuclear...
Significance Both the mitochondrial respiratory chain and reactive oxygen species (ROS) control numerous physiological pathological cellular responses. ROS such as hydrogen peroxide (H 2 O ) are thought to initiate signaling by broadly nonspecifically redox-modifying molecules, suggesting that H may be distinct from other signal transduction pathways. Here, we provide evidence is under of what appears a typical cascade connects intermembrane space-localized conserved Syk pathway results in...
Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing on microplates more efficient barcoding but labor-intensive. Here we present Overloading And unpacKing (OAK), which uses system initial compartmentalization followed second aliquoting round to achieve combinatorial indexing. We demonstrate...
Biomechanical forces and endothelial-mesenchymal transition (EndoMT) are known to mediate valvulogenesis. However, the relative contributions of myocardial contractile hemodynamic shear remain poorly understood. We integrated 4D light-sheet imaging transgenic zebrafish models with moving-domain computational fluid dynamics determine effects changes in wall stress (WSS) on ventriculobulbar (VB) valve development. Augmentation contractility isoproterenol increased both WSS Notch1b activity...
The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study rodents.POD occurs 9% 50% of older undergoing anesthesia/surgery but lacks effective treatments or prevention. High-throughput metabolomics using liquid chromatography tandem mass spectrometry has accelerated disease-related biomarkers discovery. We performed metabolomic studies humans identify potential metabolite linked POD...
Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding observed peripheral changes neurodegeneration. Here, we employ over 909k blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI),...
THE male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since shorter alleles CAG and GGC polymorphisms AR are associated with increased expression we sought to determine whether they were also behaviors. We examined 302 subjects consisting Tourette syndrome probands controls. ANOVA showed a significant association between haplotypes ADHD (p < 0.0001), conduct disorder (CD; p 0.017), oppositional defiant (ODD; 0.004) lowest scores in those...
Osmium is one of the rarer elements in seawater, with typical concentration ≈10 × 10 −15 g −1 (5.3 −14 mol kg ). The osmium isotope composition ( 187 Os/ 188 Os ratio) deep oceans 1.05, reflecting a balance between inputs from continental crust (≈1.3) and mantle/cosmic dust (≈0.13). Here, we show that ratios measured rain snow collected around world range 0.16 to 0.48, much lower than expected (>1), but similar ores (≈0.2) are processed extract platinum other metals be used primarily...