Ivana K. Kim
A5021784289- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Cutaneous Melanoma Detection and Management
- Single-cell and spatial transcriptomics
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Metabolomics and Mass Spectrometry Studies
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
- Neurological Disease Mechanisms and Treatments
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Genetic Associations and Epidemiology
- Antioxidant Activity and Oxidative Stress
- Cell Image Analysis Techniques
Harvard University
2016-2025
Massachusetts Eye and Ear Infirmary
2016-2025
University at Buffalo, State University of New York
2018-2022
New York University
2022
University of Wisconsin–Madison
2021
Augusta University Health
2021
Jacobs (United States)
2021
Mansoura University
2021
Augustana University
2021
University of Utah
2018-2020
We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH ( P < 10 −75 ), ARMS2 −59 C2/CFB −20 C3 −9 CFI −6 ). compared our top findings with the Tufts/Massachusetts General Hospital study of advanced (821 cases, 1,709 controls) genotyped 30 promising markers additional individuals (up to 7,749 4,625 controls). With these data, we identified locus TIMP3 (overall = 1.1 × −11...
An independent Safety Review Committee (SRC), supported by Novartis Pharma AG, analyzed investigator-reported cases of intraocular inflammation (IOI), endophthalmitis, and retinal arterial occlusion in the phase 3 HAWK HARRIER trials brolucizumab versus aflibercept neovascular age-related macular degeneration (nAMD).A post hoc analysis a subset data from two 2-year, double-masked, multicenter, active-controlled randomized (NCT02307682, NCT02434328).Patients (N = 1817) with untreated, active...
Background BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation few individuals from cancer-prone families. These findings suggest that constitutional changes may predispose metastatic OM familial permeation deleterious alleles could delineate new cancer syndrome. Design To characterize BAP1's contribution melanoma risk, we sequenced set 100 patients with OM, including 50 cases matched non-metastatic controls, 200...
After the Age-Related Eye Disease Study 2 (AREDS2) study, beta carotene component was replaced by lutein/zeaxanthin for development of revised AREDS supplement. However, it is unknown if increased risk lung cancer observed in those assigned persists beyond conclusion AREDS2 trial and there a benefit adding to original supplement that can be with long-term follow-up.To assess 10-year developing late age-related macular degeneration (AMD).This multicenter epidemiologic follow-up study clinical...
Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries, and affects more than 150 million worldwide. Despite effective anti-angiogenic therapies for less prevalent neovascular form AMD, treatments are lacking dry form. Similarities risk factors pathogenesis between AMD atherosclerosis have led investigators to study effects statins on incidence progression with mixed results. A limitation these studies has been heterogeneity disease lack...
Abstract Single-cell RNA-seq is a powerful tool in decoding the heterogeneity complex tissues by generating transcriptomic profiles of individual cell. Here, we report single-nuclei (snRNA-seq) study on human retinal tissue, which composed multiple cell types with distinct functions. Six samples from three healthy donors are profiled and high-quality data obtained for 5873 single nuclei. All major observed marker genes each type identified. The gene expression macular peripheral retina...
<h3>Importance</h3> Despite high rates of local tumor control in patients who are treated for uveal melanoma, most will eventually die metastasis. When metastasis develops, the liver is involved cases, and hepatic metastases particularly refractory to treatment. Finding effective treatments has been challenging. A comparison survival were over approximately 30 years may offer insights into progress that made prolonging survival. <h3>Objective</h3> To compare after treatment a cohort melanoma...
<h3>Importance</h3> Somatic mutations in<i>BAP1</i>(BRCA1-associated protein 1 gene) are frequently identified in uveal melanoma. To date, the role of germline<i> BAP1</i>mutations melanoma has not been characterized. <h3>Objective</h3> characterize clinical phenotype patients with germline<i>BAP1</i>mutations. <h3>Design, Setting, and Participants</h3> Retrospective cohort study at an academic ophthalmology referral center among 507 who consented for collection blood samples. The dates were...
Purpose.: Difficulty with night vision is a common complaint of patients age-related macular degeneration (AMD). Consistent this complaint, dark adaptation (DA) substantially impaired in these patients. Because the severity deficit, measurement DA has been suggested as means for diagnosis AMD. Previous methods were time intensive (>30 minutes), which made them unsuitable clinical use. This study evaluated rapid test (≤6.5 minutes) detection Methods.: Dark was measured by using AdaptDx...
Cell classes in the human retina are highly heterogeneous with their abundance varying by several orders of magnitude. Here, we generated and integrated a multi-omics single-cell atlas adult retina, including more than 250,000 nuclei for single-nuclei RNA-seq 137,000 ATAC-seq. Cross-species comparison among human, monkey, mice, chicken revealed relatively conserved non-conserved types. Interestingly, overall cell heterogeneity primate decreases compared that rodent retina. Through...