Clement K. Chan

ORCID: 0000-0001-7099-0976
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About
Contact & Profiles
Research Areas
  • Retinal Diseases and Treatments
  • Retinal and Macular Surgery
  • Retinal and Optic Conditions
  • Intraocular Surgery and Lenses
  • Retinal Imaging and Analysis
  • Glaucoma and retinal disorders
  • Vascular Malformations Diagnosis and Treatment
  • Ocular Diseases and Behçet’s Syndrome
  • Retinal Development and Disorders
  • Corneal surgery and disorders
  • Ophthalmology and Visual Impairment Studies
  • Sinusitis and nasal conditions
  • Ocular Infections and Treatments
  • Corneal Surgery and Treatments
  • Drug-Induced Ocular Toxicity
  • Healthcare Systems and Challenges
  • Mosquito-borne diseases and control
  • Yersinia bacterium, plague, ectoparasites research
  • Ocular Surface and Contact Lens
  • Medical and Biological Sciences
  • Viral Infections and Vectors
  • Optical Coherence Tomography Applications
  • Antioxidant Activity and Oxidative Stress
  • Global Healthcare and Medical Tourism
  • Veterinary Practice and Education Studies

Loma Linda University
2015-2024

Southern California Desert Retina Consultants
2014-2024

Bridge University
2019

California Retina Consultants
2018

VA Greater Los Angeles Healthcare System
2016

Doheny Eye Institute
2016

Black Hills Regional Eye Institute
2016

University of California, Los Angeles
2016

Cleveland Eye Clinic
2007-2010

Cleveland Clinic
2007-2010

Error in Figure in: A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Observation to Treat Vision Loss Associated Macular Edema Secondary Central Retinal Vein Occlusion: Standard Care vs Corticosteroid for Occlusion (SCORE) Study Report 5

10.1001/archophthalmol.2009.234 article EN Archives of Ophthalmology 2009-09-14
Jeffrey S. Heier Arshad M. Khanani Carlos Quezada-Ruiz Karen Basu Philip J. Ferrone and 95 more Christopher Brittain Marta S. Figueroa Hugh Lin Frank G. Holz Vaibhavi Patel Timothy Y. Y. Lai David G. Silverman Carl D. Regillo Balakumar Swaminathan Francesco Viola Chui Ming Gemmy Cheung Tien Yin Wong Ashkan M. Abbey Elmira Abdulaeva Prema Abraham Alfredo Adán Hansjürgen Agostini Arturo Alezzandrini Virgil Alfaro Arghavan Almony Lebriz Altay Payam Amini Andrew N. Antoszyk Etelka Aradi Luís Arias Jennifer Arnold Riaz Asaria Sergei Astakhov Yury S. Astakhov Carl C. Awh Chandra Balaratnasingam Sanjiv Banerjee Caroline R. Baumal Matthias Becker Rubens Belfort Galina Bratko William Jr. Z Bridges Jamin S. Brown David M. Brown M V Budzinskaya S. Buffet Stuart C Burgess Ik Soo Byon Carlo Cagini Jorge I. Calzada Stone Cameron Peter A. Campochiaro John S. Carlson Ângela Carneiro Clement K. Chan Emmanuel Chang Andrew Chang Daniel L. Chao Nauman Chaudhry Caroline Chee Andrew Cheek Shih‐Jen Chen San‐Ni Chen Chui Ming Gemmy Cheung Saradha Chexal Mark Chittum David R. Chow Abosede Cole B. Connolly Pierre Loïc Cornut Stephen Couvillion Carl J. Danzig Vesselin Daskalov Amr Dessouki François Devin Michael Dollin Rosa Dolz Louise Downey Richard F. Dreyer Pravin U. Dugel David Eichenbaum Bora Eldem Robert E. Engstrom Joan Josep Escobar Nicole Eter David Faber Naomi S. Falk Leonard Feiner Alvaro Fernandez Vega Philip J. Ferrone Marta S. Figueroa Howard F. Fine Mitchell S. Fineman Gregory M. Fox Catherine Français Pablo Moreno Franco Samantha Fraser‐Bell Nicholas Fung Federico Furno Sola Richard Gale

10.1016/s0140-6736(22)00010-1 article EN The Lancet 2022-01-24
Emily Y. Chew Traci E. Clemons Elvira Agrón Amitha Domalpally Tiarnán D L Keenan and 92 more Susan Vitale Claire Weber Douglas C. Smith William G. Christen John Paul SanGiovanni Federick L Ferris Ronald P. Danis Barbara A. Blodi Alan Ruby Andrew N. Antoszyk Ronald Klein Ivana K. Kim Gary E. Fish Wai T. Wong David H. Orth Kourous A. Rezaei Susan B. Bressler GB Hubbard Michael J. Elman Suresh Chandra Thomas R. Friberg Michael Tolentino Darmakusuma Le Mary B. Lansing Jay B. Stallman Paul Edwards Carl W. Baker Michael Novák Ricky D. Isernhagen Todd E. Schneiderman Lawrence S. Halperin Michael H. Lee David S. Boyer Philip J. Rosenfeld Pamela Rath Marc H. Levy Robert H. Rosa John C. Hoskins Clement K. Chan David M. Brown Craig M. Greven J Michael Jumper Linda J. Margulies William N. Rosenthal Richard B. Rosen Glenn Stoller Fadi El Baba W. Copley McLean Ronald Kingsley Alice T. Lyon Jeffrey S. Heier Anne E. Fung Ingrid U. Scott John A. Wells Michael J. Banach Paul M. Beer James C. Folk Joseph I. Maguire Srinivas R. Sadda Richard A. Garfinkel Judy E. Kim Paul Berstein Michael Rauser Richard A. Lewis Barron C. Fishburne Susan S. Huang Nelson R. Sabates Nicola Kim Robert N. Frank Brian C. Joondeph Odette M. Houghton Dean P. Hainsworth Edward Chaum Robert H. Millay Raymond Iezzi Rajendra S. Apte Ron A. Adelman Anita Agrawal Neelakshi Bhagat Lawrence Ulanski Steven D. Schwartz Cynthia Owsley Alan Letson Yu-Guang He Cynthia A. Toth Lawrence S. Morse Michael J. Cooney Sandeep Grover Henry Ferreyra Alexander J. Brucker David DiLoreto Aaron Weinberg

After the Age-Related Eye Disease Study 2 (AREDS2) study, beta carotene component was replaced by lutein/zeaxanthin for development of revised AREDS supplement. However, it is unknown if increased risk lung cancer observed in those assigned persists beyond conclusion AREDS2 trial and there a benefit adding to original supplement that can be with long-term follow-up.To assess 10-year developing late age-related macular degeneration (AMD).This multicenter epidemiologic follow-up study clinical...

10.1001/jamaophthalmol.2022.1640 article EN JAMA Ophthalmology 2022-06-02

To study retinal pigment epithelium (RPE) tears after off-label intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) injection for neovascular age-related macular degeneration. Eyes with a vascularized epithelial detachment (PED) that developed an RPE tear were compared eyes PED but without tear.Nine retina specialists across the United States and in Europe participated this retrospective case series. All received choroidal neovascularization (CNV) over 12 months...

10.1097/iae.0b013e3180cc2612 article EN Retina 2007-06-01

Purpose: To report 1-year follow-up of a phase 1/2a clinical trial testing composite subretinal implant having polarized human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells on an ultrathin parylene substrate in subjects with advanced non-neovascular age-related macular degeneration (NNAMD) Methods: The included 16 two cohorts. main endpoint was safety assessed at 365 days using ophthalmic and systemic exams. Pseudophakic geographic atrophy (GA) severe vision loss...

10.1167/tvst.10.10.13 article EN cc-by-nc-nd Translational Vision Science & Technology 2021-10-06

The purpose was to study preinjection optical coherence tomography-related factors in age-related macular degeneration eyes with retinal pigment epithelial detachment (PED) that may predispose (RPE) tears associated intravitreal bevacizumab injections.This multicenter retrospective case series involving 9 retina specialists and 7 centers investigated Stratus tomography (Carl Zeiss Meditec, Dublin, CA) parameters vascularized PED (vPED) from February 2006 2007. Of the 1,280 1,255 patients...

10.1097/iae.0b013e3181babda5 article EN Retina 2010-02-01

To prospectively determine the incidence and risk factors for retinal pigment epithelial (RPE) tears in eyes with vascularized detachments (PED) exudative age-related macular degeneration receiving antivascular endothelial growth factor therapy.Eyes were randomized into 1 of 4 arms: 1) 0.5 mg ranibizumab monthly 12 months; 2) 3 months then pro re nata on basis clinical optical coherence tomography-guided indications; 3) high-dose 2.0 or 4) thereafter. All PEDs measured height, greatest...

10.1097/iae.0b013e31828992f5 article EN Retina 2013-05-07

Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety preliminary efficacy of a subretinal implant consisting polarized monolayer allogeneic human embryonic stem cell-derived retinal pigmented epithelium (RPE) cells in subjects with geographic atrophy (GA) secondary dry age-related macular degeneration. Postmortem histology from one subject very...

10.1016/j.stemcr.2022.01.001 article EN cc-by Stem Cell Reports 2022-02-03

To evaluate the outcome of perfluoropropane (C3F8) gas injection for symptomatic vitreomacular traction (VMT) with or without Stage 2 macular hole (MH).A retrospective review eyes VMT treated 0.3 mL C3F8 was performed. Patients avoided supine position until resolution. small MH maintained partial face-down positioning.Forty-nine consecutive patients (50 eyes) underwent pneumatic vitreolysis between 2010 and 2016. A posterior vitreous detachment developed in 43 (86.0%) after a single...

10.1097/iae.0000000000001448 article EN Retina 2017-01-18

To evaluate the response to aflibercept therapy for Type 1 and 3 neovascularization in pigment epithelial detachments associated with treatment-naive, neovascular age-related macular degeneration.In this multicentered, prospective study, eligible eyes underwent an intravitreal injection protocol 12 months. Visual acuity morphologic features of were compared at baseline follow-up intervals between versus neovascularization.Thirty-six analyzed. At months, lesions showed a 4.5 ± 23 Early...

10.1097/iae.0000000000001271 article EN Retina 2016-09-09

Purpose To describe the unusual complication of retinal pigment epithelial (RPE) tear after intravitreal ranibizumab (Lucentis ® ) for subfoveal fibrovascular detachment (PED) and its effective management. Methods Chart review case report RPE ranibizumab. Results An inferior was documented by fluorescein angiography, fundus photography, optical coherence tomography (OCT) 1 month receiving repeat injection in right eye a patient with bilateral PED. He had undergone multiple bevacizumab...

10.1177/112067210701700432 article EN European Journal of Ophthalmology 2007-07-01
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