Sanford Chen

ORCID: 0000-0003-4054-9199
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About
Contact & Profiles
Research Areas
  • Retinal Diseases and Treatments
  • Retinal and Macular Surgery
  • Retinal and Optic Conditions
  • Retinal Development and Disorders
  • Retinal Imaging and Analysis
  • Vascular Malformations Diagnosis and Treatment
  • Intraocular Surgery and Lenses
  • Glaucoma and retinal disorders
  • Traumatic Ocular and Foreign Body Injuries
  • Effects of Vibration on Health
  • Ocular Oncology and Treatments
  • Spinal Fractures and Fixation Techniques
  • Ocular Diseases and Behçet’s Syndrome
  • Ubiquitin and proteasome pathways
  • Cancer-related Molecular Pathways
  • Central Venous Catheters and Hemodialysis
  • Ergonomics and Musculoskeletal Disorders
  • Acupuncture Treatment Research Studies
  • Spine and Intervertebral Disc Pathology
  • History of Medicine Studies
  • Ophthalmology and Visual Health Research
  • Neuroscience and Neural Engineering
  • Musculoskeletal pain and rehabilitation

Retina Vitreous Associates of Florida
2023

University of South Florida
2023

Orange County Research Center
2022

Orange County Healthcare Agency
2015-2020

Laguna Research
2008

Importance Aflibercept, 8 mg, may have greater therapeutic benefits compared with aflibercept, 2 in patients neovascular age-related macular degeneration (nAMD), including potentially improved outcomes and decreased treatment burden. Objective To assess safety efficacy of nAMD. Design, Setting, Participants The CANDELA trial was a phase 2, randomized, single-masked, open-label, 44-week clinical conducted the US. Treatment-naive active subfoveal choroidal neovascularization secondary to nAMD...

10.1001/jamaophthalmol.2023.2421 article EN cc-by-nc-nd JAMA Ophthalmology 2023-08-03

Anti-VEGF treatment of diabetic macular edema in clinical practice: effectiveness and patterns use (ECHO Study Report 1) Kevin J Blinder,1 Pravin U Dugel,2,3 Sanford Chen,4 Michael Jumper,5 John G Walt,6 David A Hollander,6 Lanita C Scott6 On behalf the ECHO Group 1The Retina Institute, St Louis, MO, 2Retinal Consultants Arizona, Phoenix, AZ, 3USC Roski Eye Keck School Medicine, University Southern California, Los Angeles, 4Orange County Retina, Santa Ana, 5West Coast Medical Group, San...

10.2147/opth.s128509 article EN cc-by-nc Clinical ophthalmology 2017-02-01

Purpose: To report 1-year follow-up of a phase 1/2a clinical trial testing composite subretinal implant having polarized human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells on an ultrathin parylene substrate in subjects with advanced non-neovascular age-related macular degeneration (NNAMD) Methods: The included 16 two cohorts. main endpoint was safety assessed at 365 days using ophthalmic and systemic exams. Pseudophakic geographic atrophy (GA) severe vision loss...

10.1167/tvst.10.10.13 article EN cc-by-nc-nd Translational Vision Science & Technology 2021-10-06

To report the end-of-study results from Ladder clinical trial of Port Delivery System with ranibizumab (PDS) for treatment neovascular age-related macular degeneration (nAMD). Multicenter, randomized, active treatment–controlled phase 2 trial. Patients diagnosed nAMD a documented response to anti–vascular endothelial growth factor who received study (N = 220). were randomized 3:3:3:2 PDS filled 10-mg/ml, 40-mg/ml, and 100-mg/ml formulations or monthly intravitreal 0.5-mg injections....

10.1016/j.oret.2020.11.004 article EN cc-by-nc-nd Ophthalmology Retina 2020-11-19

Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety preliminary efficacy of a subretinal implant consisting polarized monolayer allogeneic human embryonic stem cell-derived retinal pigmented epithelium (RPE) cells in subjects with geographic atrophy (GA) secondary dry age-related macular degeneration. Postmortem histology from one subject very...

10.1016/j.stemcr.2022.01.001 article EN cc-by Stem Cell Reports 2022-02-03

To evaluate the efficacy, safety, and injection frequency of vascular endothelial growth factor (VEGF) antagonists in treatment macular edema secondary to retinal vein occlusion (RVO) clinical practice.A multicenter retrospective study medical records 165 patients (95 branch RVO, 70 central RVO) treated with at least three anti-VEGF injections eye was conducted. Available data collected for 6 months after first included Snellen best-corrected visual acuity (BCVA), thickness (CRT) by...

10.2147/opth.s163859 article EN cc-by-nc Clinical ophthalmology 2018-04-01

To educate ophthalmologists on the potential dangers of periocular acupuncture and to describe an unusual mechanism retinal injury.A 42-year-old woman who presented with blurred central vision loss peripheral vision. Her medical history was significant for hemifacial spasms related a facial nerve injury, which she had sought treatment. Clinical examination showed vertically oriented subretinal track measuring 12 mm in length, contiguous macula, normal optic appearance foveal reflexes....

10.1097/icb.0000000000000018 article EN Retinal Cases & Brief Reports 2014-01-01

In Brief Purpose: To describe the atypical intraoperative positioning of a kyphosis patient resulting in successful retinal detachment repair. Methods: Case report. Results: A 66-year-old man presented with bilateral vision loss, and pars plana lensectomy repair were planned for left eye. Innovative surgical was required patient's severe ankylosing spondylitis–related kyphosis, fixed 90° curvature his cervical spine. With straps, orthopedic padding tape, he securely placed head-down on...

10.1097/icb.0000000000000142 article EN Retinal Cases & Brief Reports 2015-01-01

Abstract Background The purpose of this report is to describe the occurrence a retinal tear, pre-retinal and vitreous hemorrhages after completing session whole-body vibration training. Though our patient third documented case hemorrhage following training, he first show close association tear with Case presentation This describes 59-year-old male who had acute onset floaters shadows in left eye. results examination revealed temporal inferior hemorrhage, mild hemorrhage. He was successfully...

10.1186/s12886-019-1291-y article EN cc-by BMC Ophthalmology 2020-01-29

Diamond dust particles were identified within patients’ eyes both during vitrectomy procedures using diamond-dusted membrane scrapers and in postoperative clinical examinations. The had no impact on the vision caused apparent sequelae. Scanning electron microscopy analysis showed average particle size to be 23.4 μm an unequal surface area for adhesion onto soft tip. It was determined that diamond can dislodge from silicone tip of Tano insertion into valve trocars throughout operations...

10.1159/000506623 article EN cc-by-nc Case Reports in Ophthalmology 2020-03-19

10.3928/1542-8877-19970301-20 article EN Ophthalmic surgery, lasers & imaging retina 1997-03-01
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