A5058744278- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Ocular Diseases and Behçet’s Syndrome
- Iron Metabolism and Disorders
- Trace Elements in Health
- Connexins and lens biology
- Retinopathy of Prematurity Studies
- Advanced Memory and Neural Computing
- Hemoglobinopathies and Related Disorders
- Biosensors and Analytical Detection
- Vascular Malformations Diagnosis and Treatment
- Barrier Structure and Function Studies
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Machine Learning and Data Classification
- Atherosclerosis and Cardiovascular Diseases
- RNA regulation and disease
Retina Associates
2016-2024
University of Kassel
2024
University of Regensburg
2023-2024
Technical University of Darmstadt
2023
New York University
2019-2020
Duke University
2011-2018
Duke Medical Center
2012-2017
Duke University Hospital
2013-2017
University of Pennsylvania
2003-2016
Penn Presbyterian Medical Center
2002-2009
Most simian-human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding CD4 (rhCD4) limits virus entry and replication could be enhanced by substituting naturally occurring simian residues at position 375, which resides a critical location in the CD4-binding pocket is under strong positive evolutionary pressure across broad spectrum of primate lentiviruses. SHIVs...
To analyze a case series of retinal vasculitis reported to the American Society Retina Specialists (ASRS) following Food and Drug Administration approval brolucizumab for treatment neovascular age-related macular degeneration.The ASRS Research Safety in Therapeutics Committee analyzed clinical imaging characteristics from submitted reports after brolucizumab.Retinal was 26 eyes 25 patients (22 [88%] female) with brolucizumab. Imaging studies were available 24 eyes. Most cases (92%)...
Importance Aflibercept, 8 mg, may have greater therapeutic benefits compared with aflibercept, 2 in patients neovascular age-related macular degeneration (nAMD), including potentially improved outcomes and decreased treatment burden. Objective To assess safety efficacy of nAMD. Design, Setting, Participants The CANDELA trial was a phase 2, randomized, single-masked, open-label, 44-week clinical conducted the US. Treatment-naive active subfoveal choroidal neovascularization secondary to nAMD...
Mechanisms of brain and retinal iron homeostasis have become subjects increased interest after the discovery elevated levels in brains patients with Alzheimer's disease retinas age-related macular degeneration. To determine whether ferroxidase ceruloplasmin (Cp) its homolog hephaestin (Heph) are important for homeostasis, we studied from mice deficient Cp and/or Heph. In normal mice, Heph localize to Müller glia pigment epithelium, a blood-brain barrier. Mice both Heph, but not each...
<h3>Objective</h3> To investigate whether iron is involved in the pathogenesis of age-related macular degeneration (AMD). <h3>Methods</h3> Postmortem AMD-affected (nonexudative or exudative) and healthy maculas were studied using 3, 3′-diaminobenzidine–enhanced Perls Prussian blue stain. The stain was quantified by computer-assisted analysis digital images. determine chelatable, sections treated with chelator deferoxamine compared adjacent, nonchelated sections. <h3>Results</h3> Compared...
Abstract Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result steep learning curve to achieve microsurgical proficiency. We introduce surgical imaging system employing four-dimensional (live volumetric time) microscope-integrated optical coherence tomography (4D MIOCT) capable of at up 10 volumes per second visualize human microsurgery. A custom...
Iron is an essential element in human metabolism but also a potent generator of oxidative damage with levels that increase age. Several studies suggest iron accumulation may be factor age-related macular degeneration (AMD). In prior studies, both overload and features AMD were identified mice deficient the ferroxidase ceruloplasmin (Cp) its homologue hephaestin (Heph) (double knockout, DKO). this study, location timing accumulation, rate reproducibility retinal degeneration, roles stress...
The authors have recently developed a high-resolution microscope-integrated spectral domain optical coherence tomography (MIOCT) device designed to enable OCT acquisition simultaneous with surgical maneuvers. purpose of this report is describe translation from preclinical testing into human intraoperative imaging.Before imaging, conditions were fully simulated for extensive MIOCT evaluation in custom model eye system. Microscope-integrated images then acquired normal volunteers and during...
Aflibercept-related sterile inflammation, an event that is poorly understood, has been the subject of ongoing postmarketing reports.To analyze cases aflibercept-related inflammation reported to American Society Retina Specialists (ASRS) Therapeutic Surveillance Committee (TSC), independent task force formed monitor drug- and device-related safety events.A retrospective review 56 in 55 patients was performed all after aflibercept injection were voluntarily by 12 practices throughout United...
Oxidative stress is believed to be important in physiological aging and age-related diseases. Iron a potent pro-oxidant implicated several While serum ferritin, as an estimate of body stores iron, has been shown increase with age, few studies have directly addressed the effect age on human neural tissue iron levels. We used atomic absorption spectrophotometry assess quantitatively levels within eye structures, retina retinal pigment epithelium/choroid normal eyes various ages both sexes....
purpose. To study photoreceptor apoptosis and iron migration as mechanisms of retinotoxicity in a rabbit model subretinal hemorrhage (SRH) to assess intravitreal triamcinolone acetonide (IVTA) for anti-apoptotic neuroprotective effects. methods. In adult rabbits, eyes were studied histologically after injection autologous blood. For comparisons control with injected 2 mg IVTA, morphometric analysis was performed light microscopy, whereas quantified terminal dUTP nick end labeling (TUNEL)...
After the recent approval of ocriplasmin by Food and Drug Administration, postmarketing safety concerns have been raised vitreoretinal community. The American Society Retina Specialists Therapeutic Surveillance Committee was commissioned to monitor drug-related device-related adverse events. purpose this report is analyze experience in context available premarketing data.Periodic aggregate reports consisting premarketing, or clinical trial, data (n = 999 injections) through July 16, 2013...