A5051078035- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Sexual Differentiation and Disorders
- Cancer-related Molecular Pathways
- Breast Cancer Treatment Studies
- Hypothalamic control of reproductive hormones
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine Tumor Research Advances
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- interferon and immune responses
- Sperm and Testicular Function
- Plant Reproductive Biology
- Vasculitis and related conditions
- Chromatin Remodeling and Cancer
- Urological Disorders and Treatments
- Ovarian function and disorders
Riley Hospital for Children
2005-2024
Eli Lilly (United States)
2020-2024
Indiana University – Purdue University Indianapolis
2001-2024
Indiana University School of Medicine
2003-2024
Indiana University Health
2018-2024
Indiana University
2012
Icahn School of Medicine at Mount Sinai
2011
Pierre Fabre (Germany)
2010
University of Pennsylvania
2008-2010
Penn Presbyterian Medical Center
2008-2010
Iron is an essential element in human metabolism but also a potent generator of oxidative damage with levels that increase age. Several studies suggest iron accumulation may be factor age-related macular degeneration (AMD). In prior studies, both overload and features AMD were identified mice deficient the ferroxidase ceruloplasmin (Cp) its homologue hephaestin (Heph) (double knockout, DKO). this study, location timing accumulation, rate reproducibility retinal degeneration, roles stress...
Abstract Context: The LHX4 LIM-homeodomain transcription factor has essential roles in pituitary gland and nervous system development. Heterozygous mutations are associated with combined hormone deficiency. Objectives: Our objectives were to determine the nature frequency of patients deficiency examine functional outcomes observed mutations. Design: gene sequence was determined from patient DNA. biochemical regulatory properties aberrant proteins characterized using structural predictions,...
PURPOSE.Iron dysregulation can cause retinal disease, yet iron regulatory mechanisms are incompletely understood.The peptide hormone hepcidin (Hepc) limits uptake from the intestine by triggering degradation of transporter ferroportin (Fpn).Given that Hepc is expressed in retina and Fpn cells constituting blood-retinal barrier, authors tested whether may produce to limit import.METHODS.Retinas Ϫ/Ϫ mice were analyzed histology, autofluorescence spectral analysis, atomic absorption...
The Her2 oncogene is expressed in ∼25% of human breast cancers and associated with metastatic progression poor outcome. Epidemiological studies report that cancer incidence mortality rates are higher women type 2 diabetes. Here, we use a mouse model -mediated on background hyperinsulinemia to determine how elevated circulating insulin levels affect primary tumor growth lung metastasis. Hyperinsulinemic (MKR + / ) mice were crossed doxycycline-inducible Neu-NT (MTB/TAN) produce the...
Abstract Background In MONARCH 2, abemaciclib plus fulvestrant significantly improved median progression-free survival (PFS, 16.4 vs 9.3 months, hazard ratio [HR] 0.553) and overall (OS, 46.7 37.3 months; HR 0.757) compared with placebo in hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-negative (HER2-negative) advanced breast cancer (ABC) patients who were endocrine therapy (ET) resistant, regardless of menopausal status. Here, we report findings the...
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in cancer, androgen signaling activates cyclin D-CDK4/6, driving proliferation resistance hormonal manipulation prostate This study was designed detect signals of clinical activity abemaciclib treatment-refractory metastatic castration-resistant cancer (mCRPC).
Abstract Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case hypothalamic as the primary presentation toddler found to have CNS+ B‐cell lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia dramatically improved induction consolidation...
Abstract Purpose: In MONARCH 2, abemaciclib plus fulvestrant significantly prolonged progression-free survival (PFS) and overall (OS) versus placebo in patients with hormone receptor positive (HR+), HER2− advanced breast cancer. This exploratory analysis assessed the efficacy of across subgroups receiving study therapy as first- or second-line treatment for metastatic disease. Patients Methods: Improvements were estimated using Cox models, a test interactions was performed. Results: The...
Abstract MONARCH 2 is a global, randomized, double‐blind, phase 3 study of abemaciclib/placebo + fulvestrant in patients with hormone receptor positive, human epidermal growth factor 2‐negative advanced breast cancer. The East Asian population comprised 212 (31.7%) the 669 intent‐to‐treat trial. Consistent primary analysis, this subpopulation analysis indicated progression‐free survival benefit abemaciclib arm. median overall was not reached arm and 48.9 months placebo (hazard ratio 0.80;...
1068 Background: The frequent use of anthracyclines and taxanes in breast cancer's adjuvant setting has lead to drug resistance cardiac toxicity. This raised the need for new agents metastatic setting. Cisplatin-vinorelbine combination recently showed interesting results with an overall response rate 64%. Nevertheless, cisplatin was limited by frequently induced nausea, vomiting, nephrotoxicity. Liposomal (Lipoplatin) is a nontoxic alternative agent cisplatin. aim this study evaluate...
Phytoestrogens are ubiquitous compounds in nature. They found largely soy but also abundant legumes and vegetables. include a wide variety of chemicals with diverse estrogenic antiestrogenic activities. Different phytoestrogens have different mechanisms action based on estrogen receptor subtypes, endogenous concentrations, cellular genetic make-up. Effects the reproductive system been known for decades several vitro animal studies. Their roles humans remain unclear. Several beneficial health...
Polycythemia vera (PV) is a common cause of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). The postpartum period precipitating cofactor. An additional heparin-induced thrombocytopenia/thrombosis (HIT/T) leads to life-threatening condition in which transjugular intrahepatic portosystemic shunting (TIPS) seems be the only life-saving procedure. We describe case subacute BCS PVT late period. diagnosis was established using CT scan, MRI, Doppler ultrasonography abdominal vessels...
1119 Background: Capecitabine (C), vinorelbine (V) and docetaxel (D) are effective in the 1st-line treatment of metastatic breast cancer (MBC). Based on efficacy tolerability Navcap (M. Ghosn et al. Anticancer Research 2006) followed by MBC Cancer Chemother Pharmacol 2007), we initiated a 2 arm phase II randomized study. Primary Objective: To compare objective response rate (ORR) 8 cycles vs. 4 12 weekly setting MBC. Methods: Patients (pts) with measurable disease, no prior chemotherapy...
No AccessJournal of UrologyPEDIATRIC UROLOGY1 Oct 2003Turner Syndrome (45x) with Clitoromegaly NADINE G. HADDAD, GAIL H. VANCE, ERICA A. EUGSTER, MARY M. DAVIS, and MARTIN KAEFER HADDADNADINE HADDAD More articles by this author , VANCEGAIL VANCE EUGSTERERICA EUGSTER DAVISMARY DAVIS KAEFERMARTIN View All Author Informationhttps://doi.org/10.1097/01.ju.0000085983.81063.3fAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked...