A5090709150- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Glutathione Transferases and Polymorphisms
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Trace Elements in Health
- Cardiovascular Disease and Adiposity
- Extracellular vesicles in disease
- Dermatologic Treatments and Research
- Vascular Malformations Diagnosis and Treatment
- Iron Metabolism and Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Leadership, Courage, and Heroism Studies
- CNS Lymphoma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Antioxidant Activity and Oxidative Stress
- Pain Management and Treatment
- Cinema History and Criticism
- Robotics and Sensor-Based Localization
Minnesota Eye Consultants
2019-2025
Cascade Engineering (United States)
2023
University of California, Davis
2012-2020
University of Pennsylvania
2009-2014
Penn Presbyterian Medical Center
2010-2013
Ophthalmology Associates (United States)
2008
Stony Brook University
1992
State University of New York
1992
University of Minnesota
1988
First Congregational Church
1947
Age-related macular degeneration (AMD) is the leading cause of blindness in elderly. Evidence suggests oxidative stress plays a role disease. To assess potential contribution epigenetic regulation antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, tissue-specific genetic modulation that affects gene expression.Using Infinium HumanMethylation27 Illumina platform, performed bisulfite sequencing compare methylation status postmortem retina pigment epithelium...
PURPOSE.Iron dysregulation can cause retinal disease, yet iron regulatory mechanisms are incompletely understood.The peptide hormone hepcidin (Hepc) limits uptake from the intestine by triggering degradation of transporter ferroportin (Fpn).Given that Hepc is expressed in retina and Fpn cells constituting blood-retinal barrier, authors tested whether may produce to limit import.METHODS.Retinas Ϫ/Ϫ mice were analyzed histology, autofluorescence spectral analysis, atomic absorption...
To correlate retinal function and visual sensitivity with morphology revealed by ultrahigh-resolution imaging adaptive optics-optical coherence tomography (AO-OCT), on patients geographic atrophy.Five eyes from five subjects were tested (four atrophy [66.3 ± 6.4 years, mean 1 SD] one normal [61 years]). Photopic scotopic multifocal electroretinograms (mfERGs) recorded. Visual fields assessed microperimetry (mP) combined a scanning laser ophthalmoscope for high-resolution confocal fundus...
Nonarteritic anterior ischemic optic neuropathy (NAION) results in nerve damage with retinal ganglion cell (RGC) loss. An NAION model, rodent (rAION), was used to determine AION-associated mechanisms of RGC death and associated regional changes.rAION induced male Wistar rats, the retinas analyzed at various times after induction. RGCs were positively identified by both retrograde fluorogold labeling brain-expressed X-linked protein-1/2 (Bex1/2) immunoreactivity. fluorescein-tagged annexin-V...
Cell death can be induced by exogenous reactive oxygen species (ROS). Endogenous ROS also play a role in cell triggered agents that are not themselves ROS. One of the most potent ROS-generating systems is iron-catalyzed Fenton reaction. Herein, authors tested whether iron plays an important diverse stimuli retinal pigment epithelial (RPE) cells.The ability chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to chelate intracellular labile was human line ARPE-19. The SIH protect against...
Purpose To use ultra-high-resolution optical coherence tomography (OCT) subclinical anatomic alterations to explain suboptimum vision despite pseudophakic cystoid macula edema (CME) resolution. Setting University of California–Davis, Sacramento, California, USA. Design Case study. Methods This study comprised patients who had cataract phacoemulsification surgery. Cases resolved postoperative CME (diagnosed postoperatively by 1 month and year) were included. Exclusion criteria included any...
The main objective of this pilot study was to identify circulatory microRNAs in aqueous or plasma that were reflecting changes vitreous diabetic retinopathy patients. Aqueous, and samples collected from a total 27 patients undergoing vitreoretinal surgery: 11 controls (macular pucker macular hole patients) 16 with diabetes mellitus(DM): DM-Type I proliferative retinopathy(PDR) (DMI-PDR), DM Type II PDR(DMII-PDR) nonproliferative DR(DMII-NPDR). MicroRNAs isolated using Qiagen microRNeasy kit,...
Purpose.: Two methods were used to study the stages of macular telangiectasia (MacTel): Power-Doppler optical coherence tomography (PD-OCT), which allows imaging retinal circulation in three dimensions, and pigment density (MPOD), quantifies distribution carotenoids. Methods.: Among 49 patients with MacTel identified, 12 eyes (6 patients) 7 age-matched control (7 imaged a custom-built Fourier-domain OCT instrument acquire PD-OCT images. MPOD was measured using heterochromatic flicker...
Mutations in the RP1 gene can cause retinitis pigmentosa. We identified a spontaneous L66P mutation caused by two adjacent point mutations Rp1 colony of C57BL/6J mice. Mice homozygous for exhibited slow, progressive photoreceptor degeneration throughout their lifespan. Optical coherence tomography imaging found abnormal reflectivity at 1 month age. Histology shortening and disorganization inner outer segments thinning nuclear layer. Electroretinogram a- b-wave amplitudes were decreased with...
One way to problematize heterosexuality is acknowledge the tacitly assumed connection between heterosexual preference in males and their `masculinity', i.e. dissimilarity women personality behaviour. The political implications of `masculinity' construct are central what makes participation by a volatile subject for feminists. By analyzing disentangling ideological equivocation men who not sexually attracted considered resemble behaviour, it possible theorize feminist that would involve with...
Purpose: Previously, two cytosolic antioxidant enzymes, Glutathione S-transferase Mu 1 (GSTM1) and 5 (GSTM5), were reduced in retinas with age-related macular degeneration (AMD). This study compared genomic copy number variations (gCNV) of these enzymes AMD versus controls.Methods: Genomic (gCN) assays performed using Taqman Gene Copy Number Assays (Applied Biosystems, Darmstadt, Germany) technical quadruplicate for both GSTM1 GSTM5. Peripheral leukocyte RNA levels controls triplicates....
Perioperative infection and inflammation prophylaxis after ocular surgery has evolved over the years along with improvements in surgical equipment a growing interest alternatives to standard topical eye drops. The purpose of this study is evaluate outcomes novel, modified-dropless protocol for 23-gauge (23-G), 25-gauge (25-G) 27-gauge (27-G) micro-incision vitrectomy (MIVS) that omits any intraocular injections antibiotics or steroids.This Institutional Review Board-approved, single-surgeon...
To evaluate visual and safety outcomes for 25-gauge (25G) 27-gauge (27G) micro-incision vitrectomy platforms (MIVS) the treatment of epiretinal membrane full-thickness macular holes.Retrospective analysis all patients who underwent internal limiting (ILM) peel surgery from January 2017 through December 2018. 207 cases met eligibility criteria inclusion. Primary endpoint was post-operative Best-Corrected Distance Visual Acuity (BCVA) at 6 months.For combined, mean logMAR BCVA improved 0.57 (±...
We describe a case of anteriorly dislocated, Yamane-fixated secondary intraocular lens (IOLs) with pigmentary dispersion syndrome. The patient presented significant visual impairment and elevated pressure despite being maximally treated all topical antihypertensive medications. iris-IOL touch was confirmed by ultrasound biomicroscopy, fundus examination revealed evidence pigment granules on the optic disc. previous IOL repositioned using double-needle adaptation Yamane technique Kim's...