A5088808223- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Ocular Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Forecasting Techniques and Applications
- Otitis Media and Relapsing Polychondritis
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Various Chemistry Research Topics
- Connexins and lens biology
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MRI in cancer diagnosis
Minnesota Eye Consultants
2025
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Pennsylvania State University
2023
Abstract Machine learning (ML) is being widely adopted by organizations to assist in selecting personnel, commonly scoring narrative information or eliminating the inefficiencies of human scoring. This combined article presents six such efforts from operational selection systems actual organizations. The findings show that ML can score collected candidates either writing orally response assessment questions (called constructed response) as accurately and reliably judges, but much more...
Conjunctival sac microbiome alterations have been reported to be closely associated with many ocular diseases. However, the characteristic of conjunctival in allergic conjunctivitis (AC) was scarcely described. In this study, we aimed identify differences composition AC patients compared normal controls (NCs) using high-throughput 16S rDNA sequencing metagenomic analysis. The samples from 28 and 39 NC were collected. V3-V4 region rRNA gene performed on illumina MiSeq platform. Alpha...
To explore the impact of coronavirus disease 2019 (COVID-19) on prognosis patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV), share experience in managing them during pandemics.This is a retrospective study nAMD PCV treated at Peking Union Medical College Hospital from 31 December to 1 August 2020. Baseline demographic clinical characteristics, best corrected visual acuity (BCVA), optical coherence tomography (OCT) features, duration...
To study the clinical features, microbial spectrum, associated factors and prognosis of endogenous endophthalmitis (EE) in a group Chinese patients.The medical records from 32 eyes 29 patients diagnosed with EE Peking Union Medical College Hospital January 2009 to October 2019 were reviewed.The initial visual acuity (VA) 30 this was worse than 20/400. Twenty-three fungal nine bacterial endophthalmitis. The most common isolates Candida Klebsiella pneumoniae, respectively. Several rare fungi...
Abstract Background To comprehend the complexities of pathophysiological mechanisms and molecular events that contribute to proliferative diabetic retinopathy (PDR) evaluate diagnostic value aqueous humor (AH) in monitoring onset PDR. Methods A cohort containing 16 PDR 10 cataract patients another validation 8 4 were studied. AH was collected subjected proteomics analyses. Bioinformatics analysis a machine learning-based pipeline called inference biomolecular combinations with minimal bias...
Huiying Chua*, Xiangda Pengab*, Yan Lia*, Yuebin Zhanga, Hanyi Minc* & Guohui Lia*a Laboratory of Molecular Modeling and Design, State Key Reaction Dynamics, Dalian Institute Chemical Physics, Chinese Academy Science, Liaoning, Chinab University Sciences, Beijing, Chinac Medical Science Peking Union College Hospital, Ophthalmology, China
To evaluate the effect of silicone oil (SO) on peripapillary blood flow using OCT angiography. This prospective case series recruited patients with unilateral rhegmatogenous retinal detachment (RRD) who underwent vitrectomy and SO tamponade. Patients were examined before removal at 10 days, 1 month, 3 months after a spectral domain angiography device (RTVue XR Avanti, Optovue Inc., CA, USA) for measurement radial capillaries (RPC) vessel density (VD) in global field, superior hemifield,...
To report a novel surgical approach for the scleral fixation of Rayner 620 H intraocular lens (IOL) with Gore-Tex suture and its outcomes at 6 months postoperatively.19 consecutive patients who underwent IOL Peking Union Medical College Hospital between June 2020 2021 were included. Data on best-corrected visual acuity (BCVA), spherical equivalent, total astigmatism/axis, short-term long-term complications, corresponding management follow-up collected.Nineteen (11 men 8 women) mean age 62.7...
Purpose To develop diagnostic recommendations for diffuse large B-cell vitreoretinal lymphoma (VRL) in Chinese patients.Methods Retrospective observational case series. Seventy-three eyes of 40 VRL patients and 8 control were analyzed. Eighteen from Beijing Tongren Hospital 46 literature involved as validations.Results Diagnostic methods included (1) typical clinical manifestations; (2) vitreous cytology; (3) immunohistochemical examination or choroid/retina; (4) aqueous humor cytokine; (5)...
Congenital cataract (CC) is the leading cause of visual impairment or blindness in children worldwide. Because highly genetic and clinical heterogeneity, a molecular diagnosis lens disease remains challenge.In this study, we tested three-generation Chinese family with autosomal dominant CCs by targeted sequencing 45 CC genes on next generation evaluated pathogenicity detected mutation protein structure, pedigree validation, dynamics (MD) simulation.A novel 15 bp deletion GJA8...
To investigate the changes in aqueous humor (AH) protein profiles before and after intravitreal conbercept (IVC) treatment proliferative diabetic retinopathy (PDR) patients. Ten PDR patients provided 20 samples of AH (pre group) (post IVC treatment. Liquid chromatography-tandem mass spectrometry was performed to identify proteins. Bioinformatics analysis used explore functional relevance differentially expressed proteins (DEPs) hub Parallel reaction monitoring (PRM) method verify another 8 4...
Retinal pigment epithelium (RPE) dysfunction, manifested as drusen formation and RPE mottling, is a characteristic lesion of aging. The mechanism dysfunction remains unknown. Previous animal studies have proven that the activation NLRP3 inflammasome in leads to apoptosis pyroptosis, which may play very important role development age-related macular degeneration (AMD). However, there lack clinical evidence support above hypothesis. Herein, we report 38-year-old Chinese Han woman who had...
In order to determine the possible aqueous humor (AH) proteins involved in diabetic nephropathy (DN) progression, we performed gel electrophoresis-liquid chromatography-tandem mass spectrometry protein profiling of AH samples from 5 patients with proliferative retinopathy (PDR) combined DN and PDR. Function enrichment analyses were carried out after identification differentially expressed (DEPs). Protein-protein interaction networks then built Search Tool for Retrieval Interacting Genes...
Janus kinase 1 (JAK1) is a key member in the interferon (IFN) signaling pathway. Recent studies suggested single-nucleotide polymorphisms (SNPs) IFN pathway genes are associated with outcomes of hepatitis B virus (HBV) infection and response to IFNα therapy. The aim study investigate whether SNPs JAK1 were HBV therapy.We enrolled 395 chronic (CHB) patients 251 subjects inactive carrier state, 256 CHB who received treatment, therapy efficacy evaluated. Twelve SNPs: rs310227, rs7531799,...
Purpose: To evaluate the performance of xTAG liquid chip technology (xTAG-LCT) for etiological diagnosis acute retinal necrosis (ARN).Methods: Fifteen vitreous and 3 aqueous samples from 18 ARN patients were analyzed by xTAG-LCT multiplex PCR (mPCR)/quantitative (qPCR).Results: revealed positive results in 17 samples: 10 Varicella Zoster Virus (VZV) alone; 5 VZV Epstein-Barr virus (EBV); 1 herpes simplex viruses type (HSV-1) EBV; VZV, HSV-1 EBV. While mPCR same as all samples, only 2 7 EBV...
Abstract Purpose To investigate the changes in aqueous humor (AH) protein profiles before and after intravitreal aflibercept (IVA) treatment patients with proliferative diabetic retinopathy (PDR). Methods 5 PDR provided 10 samples of AH IVA (pre-group vs. post-group). Proteins were identified using liquid chromatography-tandem mass spectrometry. Then, bioinformatics was employed to functional significance differentially expressed proteins (DEPs) hub proteins. Results A total 16 DEPs...
Abstract Background To compare the value and efficiency of three-dimensional (3D) heads-up surgical system traditional microscopic (TM) in teaching learning vitreoretinal surgeries. Methods Twenty ophthalmologists scrub nurses were recruited as teachers, 45 junior ophthalmology residents trainee doctors, nurses, medical students observers. Each teacher observer assigned to both a 3D-assisted TM-assisted surgery then asked complete satisfaction questionnaires for systems at end each surgery....
In the present work, we introduce and demonstrate steps involved in using interpretable natural language processing (NLP) to predict decision-making organizational contexts. Interpretability is important for scientific advancement, bias detection mitigation, user trust, ethical legal compliance. this study, discuss why NLP interpretability a variety of methods that can be applied throughout model development process. Using assessment center data from recent machine learning competition...