A5042037984- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Multiple and Secondary Primary Cancers
- Breast Cancer Treatment Studies
- Respiratory viral infections research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Blood groups and transfusion
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
City Of Hope National Medical Center
2024-2025
Nanjing University of Aeronautics and Astronautics
2025
City of Hope
2025
Liaoning Cancer Hospital & Institute
2024
Dalian University of Technology
2024
Ministry of Education of the People's Republic of China
2024
Northwest University
2021-2024
Xi'an Medical University
2015-2024
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might contributed high-altitude adaptation Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Han Chinese, and Japanese, while Yi 75 ) performed comparable analyses on coding all genes—their exomes. Both studies converged gene, endothelial Per-Arnt-Sim domain protein 1 (also...
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, represents a male individual first known culture to settle in Greenland. Sequenced average depth 20×, we recover 79% diploid genome, amount close practical limit current sequencing technologies. identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), which 6.8% have not been reported previously. estimate raw read contamination be no higher than 0.8%. use...
Purpose: Novel biomarkers for the diagnosis of prostate cancer (PCa) are urgently required. Increasing evidence suggests that exosomal microRNAs (miRNAs or miRs) in serum may be potential noninvasive certain diseases. The objective present study was to investigate and assess whether miR-141 is an effective biomarker human PCa. Methods: In study, exosomes were isolated from patients with PCa, benign hyperplasia (BPH), healthy volunteers. total RNA extracted level analyzed by quantitative...
Abstract In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently occur PCa patients, and resorption is observed all metastatic under histopathologic assessment. The mechanisms that balance the activities of osteoblasts osteoclasts remain unclear. We unexpectedly discovered exosomes are critical mediators regulation homeostasis results osteoclastic thereby promotes tumor growth bone. evaluated how derived from...
Recent trends have identified increasing number of young individuals with rectal and colon cancers. These individuals, who are younger than 50 years old, in most instances would not meet screening guidelines. We aimed to report the characteristics trend rising proportion being diagnosed cancers at our institutions.This study included 3381 cancer patients from Mayo Clinic registry 1972 2017 were or < old. Patient described. The Cochran-Armitage test was used see if change percentage age had a...
Exosomes from cancer cells, which contain microRNA and reach metastasis loci prior to stimulate the formation of a metastatic microenvironment. Previous studies have shown that exosomal miR-141-3p is associated with prostate (PCa). However, role regulatory mechanism in microenvironment bone metastases require further study. In this study, we performed series experiments vivo vitro determine whether MDA PCa 2b cells regulates osteoblast activity promote osteoblastic metastasis. We demonstrate...
Coronavirus disease 2019 (COVID-19) is a highly infective caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). Previous studies of COVID-19 pneumonia outbreak were based on information from general population. Limited data are available for hemodialysis patients with pneumonia. This report describes clinical characteristics in an in-center patient, as well our experience implementing steps to prevent spread among patients. The diagnosis, infection control, and...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the third most common that causes large-scale infections worldwide. The correlations between pathogen susceptibility and blood type distribution have attracted attention decades ago. current retrospective study aimed to examine correlation SARS-CoV-2 infection, progression, prognosis in patients with disease 2019 (COVID-19). With 265 from multiple medical centers two established cohorts, we found A population...
Background A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection Japanese. This study evaluates effects of these risk Chinese, where HBV is most popular world. Methods and Findings We have assessed relationship between single nucleotide polymorphisms (rs3077 rs9277535) chronic independent case-control studies. The first population Chinese Han included 736 patients 782 spontaneously recovered controls. second set was...
Water-air amphibious trans-media unmanned vehicles(UAVs) have shown great potential for application due to their ability switch flexibly between air flight and underwater navigation, especially in complex missions such as search rescue, environmental monitoring, military reconnaissance, where they play a distinctive role. Through literature research, the characteristics, applications of water-air transmedia UAVs are introduced, advancements at home abroad reviewed according classification...
Electric vehicles have gained significant traction, with hybrid and fully electric cars trucks increasingly replacing traditional fuel-powered vehicles. However, the development of electrified aircraft has received comparatively less public attention. This research study aims to explore evolution aviation its future potential. It delves into history examines various types propulsion systems, including all-electric, series hybrid, parallel turboelectric configurations. The also analyzes...
ECMO techniques are commonly used to save critically ill patients with life-threatening conditions. The importance of nurses in the team and caring for has been demonstrated, but impact core competency dimension on not explored. level competence intensive care unit (ICU) is also influenced by mutiple factors. Moreover, training specialist closely related research competencies, there inconsistencies standards diverse contents exploratory stage, which still need be improved. To understand...
Iron-sulfur (Fe-S) clusters are ubiquitous cofactors essential to various cellular processes, including mitochondrial respiration, DNA repair, and iron homeostasis. A steadily increasing number of disorders being associated with disrupted biogenesis Fe-S clusters. Here, we conducted whole-exome sequencing patients optic atrophy other neurological signs mitochondriopathy identified 17 individuals from 13 unrelated families recessive mutations in FDXR, encoding the membrane-associated...
T-cell exhaustion was initially identified in chronic infection mice and subsequently described humans with cancer. Although the distinct signature of exhausted T (TEX) cells cancer has been well investigated, molecular mechanism is not fully understood. Using single-cell RNA sequencing, we report here that TEX esophageal are more heterogeneous than previously clarified. Sprouty RTK signaling antagonist 1 (SPRY1) notably enriched two subsets CD8+ cells. When overexpressed, SPRY1 impaired...
Compare overall survival (OS) and breast cancer-specific (BCSS) outcomes of conservative therapy (BCT) mastectomy in a large cohort patients with early-stage triple negative cancer (TNBC), using propensity score-based matching approach.Surveillance, Epidemiology, End Results (SEER) database was used to study the role RT early stage TNBC. Primary end points were OS BCSS. Cox proportional hazard regression models Kaplan-Meier plots generate desired outcomes. Propensity score done minimize...
Reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) has low fidelity compared with RTs other retroviruses and cellular DNA polymerases. We others have previously found that the DNA-dependent polymerization (DDDP) M184V-mutated HIV-1 RT is significantly higher than wild-type RT. Viruses containing M184V substitution are highly resistant to (−)-2′-dideoxy-3′-thiacytidine (3TC) in vitro patients treated 3TC monotherapy. It was interest determine RNA-dependent (RDDP)...