A5100770039- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Chromatin Remodeling and Cancer
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Protease and Inhibitor Mechanisms
- Genomic variations and chromosomal abnormalities
- Mitochondrial Function and Pathology
Institute of Biophysics
2016-2025
Chinese Academy of Sciences
2016-2025
Sichuan University
2022-2025
Institute of Modern Physics
2025
University of Chinese Academy of Sciences
2016-2024
Wuhan University
2023-2024
Institute of Forest Ecology, Environment and Protection
2024
Chengdu Third People's Hospital
2024
Chinese Academy of Forestry
2024
Sun Yat-sen University
2016-2023
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might contributed high-altitude adaptation Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Han Chinese, and Japanese, while Yi 75 ) performed comparable analyses on coding all genes—their exomes. Both studies converged gene, endothelial Per-Arnt-Sim domain protein 1 (also...
The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional regulation and other DNA-related biological processes. Here, we report the 11-angstrom-resolution cryogenic electron microscopy (cryo-EM) structures 30-nanometer fibers reconstituted presence linker histone H1 with different nucleosome repeat lengths. show H1-dependent left-handed twist repeating tetranucleosomal structural units, within which four nucleosomes zigzag back forth straight DNA. asymmetric...
The histone variants H3.3 and H2A.Z have recently emerged as two of the most important features in transcriptional regulation, molecular mechanism which still remains poorly understood. In this study, we investigated regulation on chromatin dynamics during activation. Our vitro biophysical biochemical investigation showed that promoted compaction repressed activity. Surprisingly, with only four to five amino acid differences from canonical H3, greatly impaired higher-ordered folding gene...
Abstract The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D organization that determines its identity. An unresolved question is how type-specific structures are established during development. Here, we analyzed in muscle cells from mice lacking the lineage transcription factor (TF), MyoD, versus wild-type mice. We show MyoD functions “genome organizer” specifies architecture to development, H3K27ac insufficient for...
Abstract In the eukaryotic nucleus, heterochromatin forms highly condensed, visible foci known as (HF). These HF are enriched with linker histone H1, a key player in condensation and silencing. However, it is unknown how H1 aggregates condenses heterochromatin. this study, we established that facilitates by enhancing inter- intrachromosomal interactions between within heterochromatic regions of Arabidopsis (Arabidopsis thaliana) genome. We demonstrated drives formation via phase separation,...
In higher eukaryotes, the centromere is epigenetically specified by histone H3 variant Centromere Protein-A (CENP-A). Deposition of CENP-A to requires chaperone HJURP (Holliday junction recognition protein). The crystal structure an HJURP–CENP-A–histone H4 complex shows that binds a CENP-A–H4 heterodimer. C-terminal β-sheet domain caps DNA-binding region heterodimer, preventing it from spontaneous association with DNA. Our analysis also revealed novel site in distinguishes its ability bind...
Histone acetylation is a hallmark for gene transcription. As histone acetyltransferase, MOZ (monocytic leukemia zinc finger protein) important HOX expression as well embryo and postnatal development. In vivo, forms tetrameric complex with other subunits, including several chromatin-binding modules regulatory functions. Here we report the solution structure of tandem PHD (plant homeodomain) (PHD12) human in free state 1.47 Å crystal H3K14ac peptide, which reveals structural basis recognition...