A5088475144- Rheumatoid Arthritis Research and Therapies
- Heme Oxygenase-1 and Carbon Monoxide
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Neonatal Health and Biochemistry
- Endometrial and Cervical Cancer Treatments
- Extracellular vesicles in disease
- Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Autoimmune and Inflammatory Disorders Research
- Circular RNAs in diseases
- Autoimmune Bullous Skin Diseases
- Intraperitoneal and Appendiceal Malignancies
- Hemoglobin structure and function
- Cannabis and Cannabinoid Research
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
Peking University Shenzhen Hospital
2021-2025
Chinese PLA General Hospital
2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Chang'an University
2024-2025
The Coordinating Center
2025
Beijing University of Posts and Telecommunications
2023-2024
Huashan Hospital
2010-2024
Fudan University
2008-2024
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might contributed high-altitude adaptation Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Han Chinese, and Japanese, while Yi 75 ) performed comparable analyses on coding all genes—their exomes. Both studies converged gene, endothelial Per-Arnt-Sim domain protein 1 (also...
Benefiting from more precise imaging and radiotherapy, patients with locoregionally nasopharyngeal carcinoma (NPC) have a significantly higher survival rate. Nonetheless, distant metastasis is still the predominant mode of failure. Advances in cancer research highlighted that pathological angiogenesis necessary for tumor by offering oxygen, nutrients, or cell metastatic conduits. MicroRNAs (miRNAs), class small noncoding RNAs, are increasingly implicated modulation physiological conditions....
Myopia is the most common ocular disorder worldwide, and high myopia in particular one of leading causes blindness. Genetic factors play a critical role development myopia, especially myopia. Recently, exome sequencing approach has been successfully used for disease gene identification Mendelian disorders. Here we show successful application to identify an autosomal dominant disorder, have identified potentially responsible monogenic form. We captured exomes two affected individuals from Han...
Nasopharyngeal cancer ( NPC ) is an endemic type of head and neck with a high rate cervical lymph node metastasis. Metastasis the major cause death in patients. Increasing evidence indicates that exosomes play pivotal role promoting metastasis by enhancing angiogenesis ECM degradation. Matrix metalloproteinase 13 important kind matrix proteinase often overexpressed various tumors increases risk However, little known about potential MMP 13‐containing . In this study, we found was cells...
Early detection of resistance to platinum-based therapy is critical for improving the treatment ovarian cancers. We have previously found that increased expression annexin A3 a mechanism platinum in cancer cells. Here we demonstrate can be detected culture medium cells, particularly these cells express high levels A3. Levels were then determined sera from patients using an enzyme-linked immunosorbent assay. Compared with those normal donors, contain significantly higher Furthermore, serum...
Abstract Exosomes are nano-vesicles secreted by tumor cells. can transfer complex biological information and induce a diverse signaling response in wide array of pathological conditions, such as hypoxia. Hypoxia is associated with aggressive phenotypes poor outcomes nasopharyngeal carcinoma (NPC) patients. Here, we analyzed the role exosomes from hypoxic NPC cells enhancing metastases normoxic hypoxia-induced factor-1α (HIF-1α)-dependent manner. HIF-1α rapidly accumulates trans-activates...
Nasopharyngeal carcinoma ( NPC ) is one of the most common malignancies head and neck. It arises from nasopharynx epithelium associated with high morbidity mortality. Long non‐coding RNA (lnc have been reported to regulate gene interaction play critical roles in carcinogenesis progression. Lnc ‐ ROR , a recently identified lnc has shown be involved initiation, progression metastasis several tumors, including hepatocellular carcinoma, breast cancer glioma. However, whether remains unknown....
Interferon stimulation of cells leads to the tyrosine phosphorylation latent Stat1 and subsequent transient accumulation in nucleus that requires canonical transport factors. However, mechanisms control predominantly cytoplasmic localization unstimulated have not been resolved. We uncovered constitutive energy- factor-independent nucleocytoplasmic shuttling is a property unphosphorylated Stat1, Stat3, Stat5. The NH2- COOH-terminal Stat domains are generally dispensable, whereas alkylation...
Heme oxygenase (HO) catalyzes the conversion of heme to biliverdin with release iron and carbon monoxide. HO-1 is highly inducible by a large number physical chemical factors. CoPP known be potent effective inducer activity in many tissues. Here we report that up-regulates via Bach1 Nrf2 human liver cells. did not influence hepatic or mRNA levels, but markedly reduced protein levels increasing degradation (t(1/2) from 19 h 2.8 h), increased decreasing 2.5 9 h). Silencing Bach1-siRNA...
To identify the rheumatoid arthritis (RA) characteristics associated with increased herpes zoster (HZ) risk in Corrona registry RA patients, and to evaluate initiators of tumor necrosis factor inhibitors (TNFi) or non-TNFi biologic agents (among those who were currently on had been previously treated methotrexate [MTX]) conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) other than MTX.Cox regression modeling estimated association between first HZ incidence selected...
Abstract Circular RNA (circRNA) is a key regulator in the development and progression of human cancers. Previous studies confirmed circRNA‐0008717 (circABCB10) as an oncogene osteosarcoma, but regulatory effect circABCB10 nonsmall cell lung cancer (NSCLC) still unclear. In current study, we examined expression different NSCLC lines. Bioinformatics analysis, Cell Counting Kit‐8 assays, Transwell migration, fluorescein reporting experiments, xenografts mice were used to detect on proliferation...
Objective: The purpose of our study is to investigate the role miR-17-5p in angiogenesis nasopharyngeal carcinoma and crosstalk between HUVECs CNE-2 via exosomes. Methods: Firstly, flow cytometry, cell viability assay, transwell tube formation were used explore angiogenesis. Then zebrafish model was confirm effects on qRT-PCR analysis Immunofluorescence assay expression NPC tissues cells compared normal control. Besides, vitro assays analyze biological functions NPC. What's more, vivo detect...
Video-assisted thoracoscopic surgery (VATS) lobectomy has been shown to be a safe, minimally invasive approach for the surgical management of lung cancer. Despite evidence supporting oncologic efficacy, recent reports indicate that less than half lobectomies are performed by VATS. We examined nationwide practice patterns identify specific predictors VATS adoption.Premier hospital data (2010 2014) were used open and procedures treatment primary Propensity score method was match operations...
// Bo You 1, * , Xiaolei Cao 2, Xiaoyi Shao 3 Haosheng Ni 1 Si Shi Ying Shan Zhifeng Gu 4 Yiwen Department of Otorhinolaryngology Head and Neck surgery, Affiliated Hospital Nantong University, Nantong, Jiangsu Province, China 2 Pathology, Medical School Pathogen Immunology, Rheumatology, These authors contributed equally to this work Correspondence to: You, e-mail: youyiwen_nantong@163.com Gu, guzhifeng@126.com Keywords: exosomes, HAX-1, nasopharyngeal carcinoma, angiogenesis, prognosis...
No published studies exist comparing the effectiveness of tofacitinib with other advanced therapies for treatment rheumatoid arthritis (RA) in real-world clinical practice. Here, we report differences compared standard care, tumor necrosis factor inhibitors (TNFi), or without concomitant methotrexate (MTX), using US Corrona registry data.
Abstract The objectives of this analysis were to assess the prevalence Sjögren’s syndrome (SS) associated with rheumatoid arthritis (RA) and compare baseline characteristics patients RA without SS. Adult from a large observational US registry (Corrona RA), ≥ 1 visit for assessment SS status between 22 April 2010 28 February 2018, considered. Patients versus compared. was determined yes/no variable reported at enrollment into Corrona follow-up visits. Outcomes unadjusted in RA, by disease...