A5022406738- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nitric Oxide and Endothelin Effects
- Respiratory and Cough-Related Research
- Receptor Mechanisms and Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Lymphoblastic Leukemia research
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Renin-Angiotensin System Studies
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Allergic Rhinitis and Sensitization
- Sarcoidosis and Beryllium Toxicity Research
- Antifungal resistance and susceptibility
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Neuroendocrine regulation and behavior
- Peptidase Inhibition and Analysis
- Spinal Fractures and Fixation Techniques
- Chronic Myeloid Leukemia Treatments
National Hospital Organization
2015-2024
Fukuoka Hospital
2015-2024
Tohoku University
1997-2024
Tokyo Metropolitan University
2011-2024
Akita University
2015-2024
Hyogo University
2024
Osaka University
1999-2024
Hokusho University
2010-2024
International University of Health and Welfare
2024
Hyogo Medical University
2022
In Brief Study Design. We evaluated the trajectories of atlantoaxial transarticular and C2-pedicle screws in 3 dimensions using computerized tomography. Objective. To compare anatomic risk for vertebral artery injury associated with screws. Summary Background Data. The fixation technique C1-lateral mass combined is considered a safer preventing than fixation. However, few reports have compared that Methods. A total 62 consecutive patients cervical lesions were 3-dimensional images...
Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by obstructive pulmonary disease remain unclear. Objectives: To assess whether use reduces the number exacerbations and improves other physiological parameters in patients with disease. Methods: We enrolled 104 participants (aged ⩾40 yr) daytime hypercapnia (Global Initiative Chronic Obstructive Lung Disease stages 2-4) receiving oxygen therapy (⩾16 h/d ⩾1 mo) randomly...
Many educators in the United States have recently become interested lesson study, a professional development approach popular Japan, as promising source of ideas for improving education (Stigler and Hiebert 1999). Numerous schools school districts attempted to use study improve their teaching practice student learning (Council Basic Education 2000; Germain- McCarthy 2001; Lewis 2002; Research Better Schools Stepanek Weeks 2001).
An 82-year-old man had been diagnosed with asthma. He experienced repeated exacerbations requiring treatment a systemic corticosteroid despite being treated medications including high-dose fluticasone furoate/umeclidinium/vilanterol, montelukast sodium, and theophylline; mepolizumab was then initiated. The patient free from for 15 months; however, he suffered post-obstructive pneumonia atelectasis secondary to mucoid impaction in the right middle lobe of lung, accompanied by productive...
Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses have properties. We reasoned that treatment with budesonide montelukast in combination might provide greater effects than either drug alone, the purpose of this study was to compare montelukast, alone or combination, on outcome variables after inhalation. Ten subjects...
We recently demonstrated that stimulation of gp130 by a combination soluble interleukin 6 receptor (sIL-6R) and IL-6 but not alone significantly stimulates the ex vivo expansion primitive hematopoietic progenitors generation erythroid cells from human CD34+ in presence stem cell factor (SCF). Here, we show is found low positively on most cells, whereas IL-6R expressed only 30-50% these cells. Although colonies generated FACS-sorted CD34+IL-6R+ were granulocyte/macrophage (GM) colonies,...
In Brief Study Design. Case report. Objective. To stress the importance of fusion angle occipitocervical spine based on an unusual case upper-airway obstruction after a posterior from occipital bone to second cervical vertebra (O–C2) in flexed position. Summary Background Data. It is well known that malalignment occipito-cervicothoracic may cause dysphagia or, rarely, dyspnea. However, best our knowledge, there have been no previous English reports prolonged O–C2 fusion. Methods. We present...
In rheumatoid arthritis (RA), it is well known that synovial fibroblasts (RSF) produce matrix metalloproteinases (MMPs) when stimulated with proinflammatory cytokines such as interleukin-1beta (IL-1beta), which causes joint destruction. We have previously shown hyaluronan (HA) inhibits IL-1beta actions in RSF via CD44, the principal HA receptor. However, CD44 mediates effects only partially, and intracellular events after binding to its receptors remain unclear. investigated role of...
ABSTRACT Background and objective: The usefulness of two tests in the serodiagnosis chronic pulmonary aspergillosis (CPA) was compared. were serum Aspergillus galactomannan antigen test (Platelia (R) ) by enzyme‐linked immunoassay (EIA) using old new cut‐off indexes, precipitating antibody test. Methods: Both Aspergillus‐ Platelia EIA positivity measured sera 28 patients at time diagnosis CPA. Results: Serum 89.3% (25/28) CPA patients. 21.4% (6/28) index (≥1.5) 50% (14/28) (≥0.5)—still less...
To examine the efficacy of selective repetitive transcranial magnetic stimulation (rTMS) therapy guided by functional near-infrared spectroscopy (fNIRS) combined with intensive speech (iST) on post-stroke patients aphasia.Eight right-handed aphasia in chronic stage after stroke were grouped into left and right hemisphere-activated for a language task based pre-intervention fNIRS. Those hemisphere activation received 1-Hz TMS to inferior frontal gyrus (RtIFG; low-frequency rTMS [LFS] group),...
Abstract A 78‐year‐old Japanese woman with no smoking history suffered from near‐fatal coronavirus disease 2019 (COVID‐19) requiring four‐week invasive mechanical ventilation, subsequent radiological features of pulmonary fibrosis. Although methylprednisolone gradually improved her respiratory condition, oxygenation and exercise tolerance had drastically deteriorated, necessitating high‐flow nasal cannula oxygen therapy. In parallel tapering systemic steroid, the patient was treated...
This study aims to explore the application of vibration stimulation for early detection and assessment knee osteoarthritis severity, using a porcine joint. Accelerometers are attached femurs tibias measure vibratory responses under simulated osteoarthritic conditions. Frequency response functions generated from acceleration data quantified root mean square deviation (RMSD) relative baseline To ensure reliability results, coherence filter is applied, confirming significant differences across...
Interferon (IFN)-γ reduces airway responses after allergen challenge in mice. The mechanisms of this effect are not clear. These studies investigate whether IFN-γ can reverse prolonged IFN-γ–deficient (IFN-γKO) Sensitized mice (IFN-γKO and wild-type [WT]) were challenged with ovalbumin. Airway responsiveness, eosinophils bronchoalveolar lavage fluid, lung lymphocyte subsets (CD4+ CD8+) measured 24 hours 8 weeks challenge. In further experiments, we treated IFN-γKO recombinant starting 4 the...
To determine the potential contribution of intermittent low-dose methotrexate (MTX) treatment (2-8 mg/week) to postoperative complications, we studied 122 patients with rheumatoid arthritis (RA) who had 201 surgical procedures. The MTX were allocated two groups: those continued (group A, 77 procedures) and discontinued more than 1 week B, 21 procedures). no group C (103 incidence infection, poor wound healing, flare-up RA was compared between three groups. Postoperative infection occurred in...
Cardio-facio-cutaneous (CFC) syndrome is a multiple congenital anomaly/mental retardation characterized by distinctive facial appearance, ectodermal abnormalities, and heart defects. Clinically, it overlaps with both Noonan Costello syndrome, which are caused mutations in 2 genes that encode molecules of the RAS/MAPK (mitogen activated protein kinase) pathway (PTPN11 HRAS, respectively). Recently, KRAS, BRAF, MEK1/2 have been identified patients CFC syndrome. Somatic KRAS BRAF various...
To assess the incidence of and risk factors associated with postherpetic neuralgia (PHN) after hematopoietic cell transplantation (HCT) varicella zoster virus (VZV) infection, we conducted a retrospective chart review 418 consecutive patients who underwent HCT between April 2005 March 2007. The male/female ratio was 221/197, median age at 47 years (range: 0-69 years), autologous/allogeneic/syngeneic 154/263/1. Seventy-eight developed VZV infection HCT. Sixty-two had localized zoster, 11...