A5103089294- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Diseases and Tuberculosis
- Cancer-related Molecular Pathways
- Infective Endocarditis Diagnosis and Management
- Medical Imaging and Pathology Studies
- Fibroblast Growth Factor Research
- Inflammasome and immune disorders
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Redox biology and oxidative stress
- Nitric Oxide and Endothelin Effects
- Protease and Inhibitor Mechanisms
- Cardiovascular Function and Risk Factors
- Diagnosis and treatment of tuberculosis
- Asthma and respiratory diseases
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Occupational and environmental lung diseases
- Occupational exposure and asthma
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
Saiseikai Fukuoka General Hospital
2016-2025
Osaka University
2024
Japan Anti Tuberculosis Association
2007-2022
Nagoya Institute of Technology
2019
Osaka National Hospital
2016-2018
University of the Ryukyus
2007-2014
Tomishiro Central Hospital
2013
Kurume University
2001-2010
University of the Ryukyus University Hospital
2009-2010
Nippon Medical School
2009
Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual pneumonia (UIP), nonspecific (NSIP) and cryptogenic organising (COP). We investigated whether periostin, a matrix protein, could be used as biomarker to assess histopathological types of IIPs. performed immunohistochemical analyses in each type IIP, examined serum levels periostin IIP patients analysed the relationship between pulmonary functions with idiopathic fibrosis (IPF)....
Approximately 20% of human cancers are estimated to develop from chronic inflammation. Recently, the NF-κB pathway was shown play an essential role in promoting inflammation-associated cancer, but JAK/STAT pathway, another important signaling proinflammatory cytokines, remains be investigated. Suppressor cytokine signaling-1 (SOCS1) acts as physiological regulator responses, and silencing SOCS1 gene by DNA methylation has been found several cancers. Here, we demonstrated that SOCS1-deficient...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of interstitial lung disease (ILD). The precise molecular mechanisms IPF remain poorly understood. However, analyses mice receiving bleomycin (BLM) as model established the importance preceding inflammation for formation fibrosis. Periostin recently characterized matricellular protein involved in modulating cell functions. We found that periostin highly expressed tissue patients with IPF, suggesting it may...
Administration of several chemotherapeutic drugs, such as bleomycin, busulfan, and gefitinib, often induces lethal lung injury. However, the precise mechanisms responsible for this drug-induced injury are still unclear. In present study, we examined role proinflammatory cytokines IL-18 IL-1beta in mechanism bleomycin-induced We performed immunohistochemical analysis receptor (R) alpha chain expression lungs five patients with Enhanced both IL-18Ralpha was observed all To support data...
SA-I, SA-II *The morphofunctional phenotype description (M) may contain more information using standard abbreviations, such as AVB, atrioventricular block; WPW, Wolff-Parkinson-White syndrome; LQT, prolongation of the QT interval; AF, atrial fibrillation; ↓R, low electrocardiogram voltages; ↓PR, short PR interval.† Organ (O) involvement in addition to H subscript (for heart) should be expanded for M
Thioredoxin (TRX) is a multifunctional redox (reduction/oxidation)-active protein that scavenges reactive oxygen species by itself or together with TRX-dependent peroxiredoxin. TRX also has chemotaxis-modulating functions and suppresses leukocyte infiltration into sites of inflammation. Leukocyte oxidative stress may be involved in the pathogenesis several diseases, including interstitial lung diseases (ILD). We examined effects two mouse models human ILD. Recently, we established new model...
In response to vascular insults, inflammatory cytokines stimulate smooth muscle cells (SMCs) express an inducible isoform of nitric oxide synthase (iNOS). Asymmetric dimethylarginine (ADMA), endogenous NO inhibitor, is metabolized by dimethylaminohydrolase (DDAH). To determine whether the ADMA-DDAH system regulates cytokine-induced production, cultured rat SMCs were exposed interleukin-1beta (IL-1beta). IL-1beta (1 100 U/mL) dose-dependently stimulated not only iNOS but also DDAH expression...
Interleukin (IL)-18 production and pulmonary function were evaluated in patients with chronic obstructive disease (COPD) order to determine the role of IL-18 COPD. Immunohistochemical techniques used examine lungs very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV, n = 16), smokers (n 27) nonsmokers 23). Serum cytokine levels analysed GOLD I-IV 62), 34) 47). Persistent small airway inflammation was observed ex-smokers proteins strongly expressed alveolar...
Background —The Rho/Rho-associated kinase (Rho-kinase) system is implicated in various cellular functions, including migration, proliferation, and apoptosis. Because a possible role of the suggested neointima formation after vascular injury, we sought to examine whether new specific Rho-kinase inhibitor, Y27632, prevents balloon-injured rat carotid artery, if so, investigate effects Y27632 on apoptosis smooth muscle cells (SMCs) injured artery. Methods Results —Y27632 was administered...
Hypertensive patients with large blood pressure variability (BPV) have aggravated end-organ damage. However, the pathogenesis remains unknown. We investigated whether exaggerated BPV aggravates hypertensive cardiac remodeling and function by activating inflammation angiotensin II–mediated mechanisms. A model of superimposed on chronic hypertension was created performing bilateral sinoaortic denervation (SAD) in spontaneously rats (SHRs). SAD increased to a similar extent Wistar Kyoto SHRs...
The purpose of this study was to evaluate the MR findings ganglioneuroma and correlate imaging histologic features.Conventional SE contrast-enhanced dynamic MRI used examine 10 patients with pathologically confirmed ganglioneuroma. morphologic features, signal intensity, enhancement pattern tumors were retrospectively analyzed correlated features.Capsules present in all histologically also detected five on postcontrast T1-weighted images. A whorled appearance corresponding interlacing...
Cytokines exert biological functions by activating Janus tyrosine kinases (JAKs), and JAK inhibitors JAB (also referred to as SOCS1 SSI1) CIS3 (SOCS3) play an essential role in the negative regulation of cytokine signaling. We have found that transgenic (Tg) mice expressing a mutant (F59D-JAB) exhibited more potent STAT3 activation severe colitis than did wild-type littermates after treatment with dextran sulfate sodium. now find there is prolonged JAKs STATs response number cytokines T...
ABSTRACT Resistance of Mycobacterium tuberculosis to pyrazinamide (PZA) derives mainly from mutations in the pncA gene. We developed a reverse hybridization-based line probe assay with oligonucleotide probes designed detect . The detection PZA resistance was evaluated 258 clinical isolates M. sensitivity and specificity obtained by this new were both 100%, consistent results conventional susceptibility testing. This can be used sputa patients. It appears reliable widely applicable and, given...
Background:It has been shown that increased short-term blood pressure (BP) variability (BPV) aggravates hypertensive cardiac remodeling in spontaneously rats (SHRs) through a angiotensin II (angII) system. However, little was known about the renal damage induced by large BPV. Thus, histological changes kidney were investigated and candesartan, an angII type 1 receptor blocker (ARB), also examined to see whether it would prevent SHRs with BPV.Methods Results:Bilateral sinoaortic denervation...
Liver abscesses can be associated with biliary disease and are occasionally accompanied by portal vein thrombosis. Hepatic artery obstruction has been reported to result from aneurysms, thrombosis, iatrogenic factors, arterial dissection; however, the best of our knowledge, no cases liver abscess hepatic have reported. A 51-year-old man presented a chief complaint heartburn. detailed investigation revealed common bile duct stones an 8-cm multilocular in left lobe liver. Choledocholithiasis...
A 69-year-old woman was diagnosed with extrahepatic portal vein occlusion and liver cirrhosis. Computed tomography (CT) magnetic resonance imaging (MRI) revealed a ring-enhanced tumor. tumor biopsy detected small bile duct proliferation without atypia map-like pattern on immunostaining for glutamine synthetase, resulting in focal nodular hyperplasia diagnosis. CT after 4 years the increased The patient suspected of intrahepatic cholangiocarcinoma based MRI findings. re-conducted, (small...