A5072949193- Nitric Oxide and Endothelin Effects
- Kawasaki Disease and Coronary Complications
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Hormonal Regulation and Hypertension
- Congenital Heart Disease Studies
- Cardiovascular Conditions and Treatments
- Eicosanoids and Hypertension Pharmacology
- Blood Pressure and Hypertension Studies
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Molecular Biology Techniques and Applications
- Congenital heart defects research
- Coronary Interventions and Diagnostics
- Renin-Angiotensin System Studies
- Angiogenesis and VEGF in Cancer
- Parathyroid Disorders and Treatments
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Circular RNAs in diseases
Oregon Health and Science University Hospital
2024
University of Washington
2017-2024
Seattle Children's Hospital
2024
Kurume University
2009-2017
Seattle University
2015
Cardiovascular Institute Hospital
2009-2014
University of the Ryukyus
2009
Kyushu University
2009
Tokyo Women's Medical University
2006-2009
University of Alberta
2007-2008
The etiology of hepatopulmonary syndrome (HPS), a common complication cirrhosis, is unknown. Inflammation and macrophage accumulation occur in HPS; however, their importance unclear. Common bile duct ligation (CBDL) creates an accepted model HPS, allowing us to investigate the cause HPS.
Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition O2-sensitive K+ channels in DA smooth muscle cells. Subsequent membrane depolarization and calcium influx through L-type initiates functional closure. We hypothesize that Rho-kinase activation an additional mechanism sustains constriction.The effect increased PO2 on activity expression was assessed DAs from neonates with hypoplastic left-heart syndrome (n=15) rabbits (339 term 99 preterm rabbits). inhibitors...
Background In muscular dystrophy, cardiac function deteriorates with time and heart failure is one of the major causes death. Although combination angiotensin-converting enzyme inhibitors (ACEI) β-blockers improves in adults, little known about efficacy those drugs patients dystrophy. Methods Results The effect β-blocker, carvedilol, and/or ACEI on ventricular dystrophy was studied. Carvedilol an were given to 13 (ACEI group; mean age 18 years, range 7-27 years), only 15 (carvedilol 8-29...
Hypertensive patients with large blood pressure variability (BPV) have aggravated end-organ damage. However, the pathogenesis remains unknown. We investigated whether exaggerated BPV aggravates hypertensive cardiac remodeling and function by activating inflammation angiotensin II–mediated mechanisms. A model of superimposed on chronic hypertension was created performing bilateral sinoaortic denervation (SAD) in spontaneously rats (SHRs). SAD increased to a similar extent Wistar Kyoto SHRs...
Introduction Kawasaki disease (KD) is a diffuse vasculitis in children. Response to high dose intravenous gamma globulin (IVIG), the primary treatment, varies according genetic background. We sought identify loci, which associate with treatment response using whole genome sequencing (WGS). Method performed WGS 472 KD patients 305 IVIG responders and 167 non-responders defined by AHA clinical criteria. conducted logistic regression models test additive effect entire cohort four subgroups...
Background The basic mechanisms of thromboembolism in cyanotic congenital heart disease (CCHD) have not been well clarified. P-selectin on the platelets reflects platelet activation. Thrombomodulin is a critical cofactor for thrombin-mediated activation protein C and anticoagulant activity endothelium. present study was performed to evaluate whether exists patients with CCHD. Methods Results Platelet as marker activation, plasma thrombomodulin level markers endothelium thrombin -...
Background:It has been shown that increased short-term blood pressure (BP) variability (BPV) aggravates hypertensive cardiac remodeling in spontaneously rats (SHRs) through a angiotensin II (angII) system. However, little was known about the renal damage induced by large BPV. Thus, histological changes kidney were investigated and candesartan, an angII type 1 receptor blocker (ARB), also examined to see whether it would prevent SHRs with BPV.Methods Results:Bilateral sinoaortic denervation...
Obesity may affect the clinical course of Kawasaki disease (KD) in children and multisystem inflammatory syndrome (MIS-C) associated with COVID-19.
AimsUnsatisfactory effects of therapeutic angiogenesis in critical limb ischaemia may be ascribed to use circulating angiogenic cells (CACs) derived from atherosclerotic patients with impaired neovascularization-related capacities. We tested whether ultrasound cell stimulation can restore the
Background: Thromboembolic events account for significant morbidity and mortality after the Fontan procedure, but underlying mechanisms remain unclear. P-selectin on platelets indicates platelet activation. Thrombomodulin (TM), a receptor thrombin major anticoagulant proteoglycan endothelial membrane, reflects activity of endothelium. The present study investigated hypothesis that balance between activation biological function is impaired in patients. Methods Results: Platelet as marker...
Background: Hypertensive patients with large blood pressure variability (BPV) have aggravated target organ damage. Because the aldosterone/mineralocorticoid receptor (MR) system is a possible mechanism of hypertensive damage, we investigated in spontaneously rats (SHRs) whether specific MR blocker, eplerenone, would prevent BPV-induced aggravation cardiac remodeling. Methods and Results: A rat model combination hypertension BPV was created by performing bilateral sinoaortic denervation (SAD)...
The effects of therapeutic angiogenesis by intramuscular injection early pro-angiogenic cells (EPCs) to ischemic limbs are unsatisfactory. Oxidative stress in the may accelerate apoptosis injected EPCs, leading less neovascularization. Forkhead transcription factor 4 (FOXO4) was reported play a pivotal role signaling EPCs response oxidative stress. Accordingly, we assessed whether FOXO4-knockdown (FOXO4KD-EPCs) could suppress stress-induced and augment neovascularization capacity limbs. We...
Extracorporeal membrane oxygenation (ECMO) provides a rescue for children with severe cardiac failure. It has previously been shown that triiodothyronine (T3) improves function by modulating pyruvate oxidation during weaning. This study focused on fatty acid (FA) metabolism modulated T3 weaning from ECMO after injury. METHODS AND RESULTS: Nineteen immature piglets (9.1-15.3 kg) were separated into 3 groups (6.5 h) and wean: normal circulation (Group-C); transient coronary occlusion (10 min)...
Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence silencing cell cycle genes. Cardiac myocytes (CMs) accumulate during demethylation H3K9me3 inhibits gene exit CMs; however, it unclear if this process mediated HP1s. In study, we created a conditional CM-specific HP1 gamma (HP1γ) knockout (KO) mouse model tested whether HP1γ required for cardiac growth. KO mice...
Abstract Kawasaki disease (KD) is a multisystem inflammatory illness of infants and young children that can result in acute vasculitis. The mechanism coronary artery aneurysms (CAA) KD despite intravenous gamma globulin (IVIG) treatment not known. We performed Whole Genome Sequencing (WGS) association analysis racially diverse cohort patients treated with IVIG, both using AHA guidelines. defined aneurysm ( N = 234) as z ≥ 2.5 large (CAA/L) (N 92) 5.0. conducted logistic regression models to...
Background. The heart consists of various kinds cell components. However, it has not been feasible to separately analyze the gene expression individual laser microdissection (LMD) method, a new technology collect target cells from microscopic regions, used for malignancies. We sought establish method selectively muscular and vascular regions sections compare marker expressions with this method. Methods Results. Frozen left ventricle were obtained Wistar-Kyoto rats (WKY) stroke-prone...