A5075967215- Cervical Cancer and HPV Research
- HIV Research and Treatment
- Kawasaki Disease and Coronary Complications
- Hepatitis B Virus Studies
- Genetic Associations and Epidemiology
- Genital Health and Disease
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Viral-associated cancers and disorders
- Reproductive tract infections research
- Colorectal and Anal Carcinomas
- HIV/AIDS Research and Interventions
- Global Cancer Incidence and Screening
- Coronary Artery Anomalies
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Cardiovascular Issues in Pregnancy
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- Immunodeficiency and Autoimmune Disorders
- Migration, Health and Trauma
- Gene expression and cancer classification
- Herpesvirus Infections and Treatments
University of Alabama at Birmingham
2016-2025
Alabama Department of Public Health
2025
University of North Florida
2024
University of Florida
2024
O'Neal Comprehensive Cancer Center
2022
University of Alabama
2021-2022
Jefferson County Department of Health
2019-2020
Brigham and Women's Hospital
2020
University of Washington
2012-2017
San Francisco VA Medical Center
2013
Breast cancer (BCa), a leading malignancy among women, is characterized by morphological and molecular heterogeneity. While early-stage, hormone receptor, HER2-positive BCa are treatable, triple-negative metastatic remains largely untreatable. Advances in sequencing proteomic technologies have improved our understanding of the alterations that occur during initiation progression enabled identification subclass-specific biomarkers therapeutic targets. Despite availability abundant omics data...
Background— A functional polymorphism in the inhibitory IgG-Fc receptor gene Fc γ RIIB influences intravenous immunoglobulin (IVIG) response Kawasaki disease (KD), a vasculitis preferentially affecting coronary arteries children. We tested hypothesis that polymorphisms activating receptors ( RIIA , RIIIA and RIIIB ) also influence susceptibility, IVIG treatment response, artery patients with KD. Methods Results— genotyped using pyrosequencing 443 KD, including 266 trios 150 single...
Abstract Background Menstruation, a natural biologic process is associated with restrictions and superstitious beliefs in Nepal. However, factual data on women’s perspectives menstrual practices are scarce. This study aimed to assess socio-cultural perceptions of among urban Nepalese women the Kathmandu valley. Methods Using clustered random sampling, 1342 adolescent girls menstruating age (≥15 years) from three districts valley completed survey related restriction. was cross-sectional using...
Whole-genome multiomic profiles hold valuable information for the analysis and prediction of disease risk progression. However, integrating high-dimensional multilayer omic data into risk-assessment models is statistically computationally challenging. We describe a statistical framework, Bayesian generalized additive model ((BGAM), present software inputs models. used BGAM from The Cancer Genome Atlas survival after diagnosis breast cancer. developed sequence studies to (1) compare...
AbstractNotI linking clones, localized to the human chromosome 3p21.3 region and homozygously deleted in small cell lung cancer lines NCI-H740 NCI-H1450, were used search for a putative tumor suppressor gene(s). One of these NL1G210, detected 2.5-kb mRNA all examined tissues, expression being especially high heart skeletal muscle. Two overlapping cDNA clones containing entire open reading frame isolated from library fully characterized. Computer analysis GenBank database revealed sequence...
The implementation of highly active antiretroviral therapy (HAART) among HIV-positive patients results in immune reconstitution, slower progression HIV disease, and a decrease the occurrence opportunistic infections. However, impact HAART on cervical human papillomavirus (HPV) infection, clearance, persistence high-risk adolescents remains controversial. HIV-negative female were enrolled Reaching for Excellence Adolescent Care Health (REACH) longitudinal cohort study. At each semi-annual...
AbstractDeclines in HIV care and treatment adherence among HIV-infected women from pregnancy to the postpartum period have significant implications for clinical outcomes overall well-being of women, especially due immunosuppression during period. While increased risk mortality associated with discontinuation is well established, reasons nonadherence are largely unknown. Eighteen were recruited four clinics Alabama participate focus groups or individual interviews discuss barriers...
Persistent infection with human papillomavirus (HPV) causes essentially all precancerous cervical lesions and cancer in females thus is an important intermediate phenotype to cancer. A majority of infected individuals naturally clear HPV viral infection, but the virus persists a subset hosts mechanism for this differential outcome not well described. Most epidemiological studies have been cross-sectional nature, even longitudinal studies, definition persistence or clearance has defined....
Background: This study assessed human papillomavirus (HPV), cervical cancer, and HPV vaccine knowledge awareness among women in two sub-populations Nepal - Khokana, a traditional Newari village the Lalitpur District about eight kilometers south of Kathmandu, Sanphebagar, development committee within Achham rural Far-Western Nepal. Methods: Study participants were recruited during health camps conducted by Fertility Care Center, Nepali non-governmental organization. Experienced staff...
Introduction Kawasaki disease (KD) is a diffuse vasculitis in children. Response to high dose intravenous gamma globulin (IVIG), the primary treatment, varies according genetic background. We sought identify loci, which associate with treatment response using whole genome sequencing (WGS). Method performed WGS 472 KD patients 305 IVIG responders and 167 non-responders defined by AHA clinical criteria. conducted logistic regression models test additive effect entire cohort four subgroups...
Background: The role of host genetics in the development subclinical atherosclerosis context HIV-infected persons who are being treated with highly active antiretroviral therapy (HAART) is not well understood. Methods: present genome-wide association study (GWAS) based on 177 HIV-positive Caucasian males receiving HAART participated Fat Redistribution and Metabolic Change HIV Infection (FRAM) Study. Common internal carotid intima–media thicknesses (cIMT) measured by B-mode ultrasound were...
Background: Rurality, race, and age at diagnosis are important predictors in head neck cancer (HNC) prognosis. However, literature on the associations of rurality race with HNC is limited. Data geographical, racial, gender disparities young patients (diagnosed ≤45 years) also scarce. Materials Methods: This retrospective study assesses rural-urban, diagnosis, using electronic medical records (Cerner) data 4258 (1538 residing rural counties 2720 urban counties) from National Cancer...
Some individuals are readily infected with low human immunodeficiency virus type 1 (HIV-1) exposure, whereas others appear less susceptible, suggesting that host genetics plays a role in the viral entry pathway. The matched case-control study design measured risk exposures provides an avenue for discovering genes involved susceptibility to infection.
Summary Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of highly effective vaccine. Approximately 5% HBV‐infected adults develop chronic hepatitis B, which may result in liver cirrhosis or hepatocellular carcinoma. Variants interleukin‐10 ( IL10 ) have been previously associated with and progression to Single nucleotide polymorphisms (SNP; n = 42) from , IL19 IL20 gene regions were examined for an association HBV outcome, either recovered,...
Objective: In a recent genome-wide association study of HIV-1-infected individuals in the Euro-CHAVI cohort, viral load set-point was strongly associated with genotypes defined by two single nucleotide polymorphisms (SNPs) (rs9264942 and rs2395029) within human major histocompatibility complex (MHC) region on chromosome 6. We attempted to confirm this finding African–Americans address whether these SNPs are linkage disequilibrium leukocyte antigen (HLA) class I alleles that mediate innate...
Nepal has one of the highest cervical cancer rates in South Asia. Only a few studies populations from urban areas have investigated type specific distribution human papillomavirus (HPV) Nepali women. Data on high-risk HPV (HR-HPV) types are not currently available for rural Nepal. We aimed to assess HR- among women while assessing self-collected and clinician-collected cervico-vaginal specimens as sample collection methods screening.Study participants were recruited during health camp...