A5040151362- Asthma and respiratory diseases
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Sharing Economy and Platforms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Vascular Malformations and Hemangiomas
- Pulmonary Hypertension Research and Treatments
- Health, psychology, and well-being
- Indoor Air Quality and Microbial Exposure
- Vascular Malformations Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Occupational exposure and asthma
- Eosinophilic Esophagitis
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Blood Coagulation and Thrombosis Mechanisms
- Bone health and osteoporosis research
- Smoking Behavior and Cessation
- Immunodeficiency and Autoimmune Disorders
- Inhalation and Respiratory Drug Delivery
- Health Literacy and Information Accessibility
- Sarcoidosis and Beryllium Toxicity Research
University of Alberta
2014-2024
Alberta Hospital Edmonton
2022-2023
Deleted Institution
2023
National Institute of Neurological Disorders and Stroke
2023
University of Saskatchewan
2020
Memorial University of Newfoundland
2020
University of Alberta Hospital
2012
King's College Hospital NHS Foundation Trust
2011
McMaster University
2000-2006
St. Joseph’s Healthcare Hamilton
2000-2002
Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses have properties. We reasoned that treatment with budesonide montelukast in combination might provide greater effects than either drug alone, the purpose of this study was to compare montelukast, alone or combination, on outcome variables after inhalation. Ten subjects...
Background and Purpose— Hereditary hemorrhagic telangiectasia (HHT) is a systemic disease characterized by mucocutaneous telangiectasias, epistaxis, arteriovenous malformations (AVMs). Intracranial hemorrhage (ICH) rates in this population are not well described. We report ICH characteristics HHT patients with brain AVMs (HHT-BAVMs). Methods— studied the first 153 HHT-BAVM follow-up data enrolled Brain Vascular Malformation Consortium Project. estimated after BAVM diagnosis. Results— The...
Objective: Many household products contain fragrances. Little is known about exposure to fragrances on human health, particularly within the airways. This study aimed evaluate how common fragrance (i.e. air fresheners, cleaning products) affect people with asthma, who frequently report sensitivity these products. of have volatile organic compounds or semi-volatile compounds. evaluated nine materials in an aerosol formulation assess effects airway physiology, inflammation and symptom...
Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) is a receptor for PGD2 and by T cells, eosinophils, basophils, ILC2 cells. CRTh2 expression CD4(+) identifies the subset, these have been characterized as allergen-specific central memory Recently, activation of -CRTh2 pathway in lungs was associated with severe asthma.To assess circulating levels related mediators asthma those who experience exacerbations.Peripheral blood expressing were flow cytometry qRT-PCR....
We report the case of a 54-year-old woman who underwent living-related renal transplantation for end-stage disease from IgA nephropathy. She was subsequently diagnosed with antibody-mediated rejection (AMR) and received rituximab, potent B-cell suppressive agent. After therapy she developed Pneumocystis jirovecii pneumonia (PJP) requiring hospitalization. discuss increasing literature use rituximab AMR need PJP prophylaxis in this setting.
Background Protease-Activated Receptor-2 (PAR-2), a G protein coupled receptor activated by serine proteases, is widely expressed in humans and involved inflammation. PAR-2 activation the airways plays an important role development of allergic airway expression known to be upregulated epithelium asthmatic subjects, but its on immune inflammatory cells patients with asthma has not been studied. Methods We recruited 12 severe 24 mild/moderate asthmatics from University Alberta Hospital Asthma...
People with severe asthma account for 5% to 10% of all asthmatic patients; however, this small group uses the majority health care resources. Novel methods are needed cope burden that minority patients places on system. A clinic patient, who was monitored through University Alberta’s Virtual Asthma Clinic (Edmonton, Alberta) is presented. Despite optimization his disease and individualized education (provided by a certified educator), patient remained oral glucocorticosteroids (OGS) control...
Abnormal gastrointestinal permeability (GIP) has been implicated in a number of diseases, including chronic intestinal inflammatory disorders such as Crohn's well non-intestinal immunologic diseases diabetes and multiple sclerosis. Although evidence the literature demonstrates mucosal abnormalities digestive barrier asthma, previous studies have assessed only colonic permeability, while ignoring mucosal-associated lymphoid tissue (MALT) rich areas small intestine. Alterations GIP may lead to...
A 30-year-old female presented shortly after cadaveric renal transplantation with respiratory distress typical of a bacterial infection. Following initial improvement, she developed progressive failure, initially felt to be secondary cytomegalovirus Two bronchoalveolar lavages were nondiagnostic, and an open lung biopsy was performed, which revealed pulmonary alveolar proteinosis (PAP) reaction exogenous lipid pneumonia (ELP). The ELP considered the use marijuana, in form weed oil, that...
The purpose of this study was to explore the perceptions about self-management among people who were being followed up in a severe asthma clinic by specialists for confirmed, overall asthma. Such insight informs how best tailor programs difficult treat patient population.In-depth tape-recorded interviews eight adults with transcribed and analyzed salient themes using content analysis.To self-manage their illness, over time participants sought information from variety sources that they often...
Steroids, inhaled and systemic, are used to treat airway inflammation in patients with asthma; however, steroids recognized cause a number of side effects, including osteoporosis. We evaluated the prevalence osteopenia/osteoporosis moderate-severe asthma managed through Edmonton Regional Severe Asthma Centre.We performed retrospective chart review analyzed 57 charts on followed specialty clinic, recorded their bone mineral density (BMD). Steroid use was reviewed frequency compared requiring...
Hereditary hemorrhagic telangiectasia (HHT) is a disease of abnormal vasculature where patients are predisposed to strokes multiple etiologies. We assessed yearly stroke incidence among Albertans with HHT and compared the general population. Given tendency for in patients, we expected have higher incidence, particular at younger ages.Population-based administrative health data on inpatient ambulatory admissions were extracted over 16-year period using International Classification Diseases...
Contrast transthoracic echocardiography (TTCE) is used to screen hereditary hemorrhagic telangiectasia (HHT) patients for right-to-left shunts (RLS) associated with increased stroke risk. We hypothesized that contrast transcranial Doppler (TCDc), shown be highly sensitive detecting RLS in patent foramen ovale, will as comparable TTCE screening HHT patients.We compared and TCDc 12 who also underwent CT pulmonary studies determine arteriovenous malformation (PAVM) presence. The sensitivity...
A case of persistent hematologic abnormalities in a patient receiving long-term omalizumab therapy for severe asthma is reported.During the course her treatment at an clinic, 24-year-old woman was noted to have increased white blood cell counts, with elevated myeloid counts; were first documented more than 12 months previously. The had been taking 2 years and also immune globulin common variable immunodeficiency. Based on results bone marrow aspiration biopsy, she diagnosed as having mild...
To assess the prevalence of co-morbid psychiatric disorders in asthmatic patients a Western Canadian Regional Severe Asthma Center.A prospective study was completed evaluated through Edmonton Clinic (ERSAC). A standardised evaluation, Mini International Neuropsychiatric Interview (MINI) screen used to identify possible disorders.Twenty-four individuals with moderate severe asthma, who presented for treatment at ERSAC, were recruited and underwent assessment MINI screen. The average patient...
Asthma is an independent risk factor for invasive pneumococcal disease; however, the immune response of adult asthma patients to vaccination unknown. We explore serologic with moderate severe 23-valent polysaccharide vaccine (PPSV23).Seventeen that had not been vaccinated against pneumococcus over 5 previous years were prospectively recruited from a tertiary care clinic. Serum was analyzed presence antibodies five capsular (CP) antigens (6B, 9V, 19A, 19F, 23F) before and 4 weeks after PPSV23...
Severe asthma constitutes a subgroup of approximately 10% all cases. Approximately one-half these individuals have refractory form the disease in which atopy and T-helper cell 2-skewed immunological response may not be as closely linked to other phenotypes asthma. This suggests that is explained by response, mechanisms important this category nonatopic The authors present case involving 55-year-old Caucasian man with nonatopic, adult-onset asthma, nonsteroidal anti-inflammatory drug...
A 39-year-old right-handed man presented to his family physician with sudden-onset weakness in right arm and leg that had lasted 10 minutes resolved completely. In the year before presentation, he an episode of on side face difficulty comprehending