A5087705837- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Delphi Technique in Research
- IL-33, ST2, and ILC Pathways
- School Health and Nursing Education
- Voice and Speech Disorders
- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Clinical practice guidelines implementation
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Health Policy Implementation Science
- Eosinophilic Esophagitis
- Pharmacological Effects and Assays
- Neuroscience of respiration and sleep
- Health Literacy and Information Accessibility
- Olfactory and Sensory Function Studies
- Dermatology and Skin Diseases
- Respiratory Support and Mechanisms
- Food Allergy and Anaphylaxis Research
Université Laval
2016-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015-2024
University of British Columbia
2006-2024
University of Toronto
2006-2024
Université de Montréal
2007-2024
St. Michael's Hospital
2016-2024
University of Ottawa
2024
McGill University
2006-2024
University of Calgary
2024
University of Saskatchewan
2003-2024
The assessment of asthma control is pivotal to the evaluation treatment response in individuals and clinical trials. Previously, control, severity, exacerbations were defined assessed many different ways.The Task Force was established provide recommendations about standardization outcomes relating trials practice, for adults children aged 6 years or older.A narrative literature review conducted evaluate measurement properties strengths/weaknesses outcome measures relevant exacerbations....
Abstract Background Asthma is a major cause of disability, health resource utilization and poor quality life world-wide. We set out to generate estimates the global burden asthma in adults, which may inform development strategies address this common disease. Methods The World Health Survey (WHS) was developed implemented by Organization 2002-2003. A total 178,215 individuals from 70 countries aged 18 45 years responded questions related symptoms. prevalence based on responses relating...
Thymic stromal lymphopoietin (TSLP) is an epithelial-cell-derived cytokine that may be important in initiating allergic inflammation. AMG 157 a human anti-TSLP monoclonal immunoglobulin G2λ binds TSLP and prevents receptor interaction.In this double-blind, placebo-controlled study, we randomly assigned 31 patients with mild asthma to receive three monthly doses of (700 mg) or placebo intravenously. We conducted allergen challenges on days 42 84 evaluate the effect reducing maximum percentage...
Eosinophilic asthma is a phenotype of characterized by the persistence eosinophils in airways. IL-5 involved activation and survival eosinophils.To evaluate effect antibody to IL-5, reslizumab, patients with eosinophilic that poorly controlled high-dose inhaled corticosteroid.Patients were randomly assigned receive infusions reslizumab at 3.0 mg/kg (n = 53) or placebo baseline Weeks 4, 8, 12, stratification Asthma Control Questionnaire (ACQ) score less than equal 2 greater 2. The primary...
The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions motor vehicles, the rising trend can only be explained by gross changes in environments where we live. world economy been transformed over last 25 years with developing countries being at core these changes. Around planet, both developed countries, are undergoing profound Many considered have negative...
Inhaled allergens, acting through IgE-dependent mechanisms, are important triggers of asthma symptoms and inducers airway hyperresponsiveness inflammation. The effect anti-IgE recombinant humanized monoclonal antibody-E25 (rhuMAb-E25) on the provocation concentration allergen causing a 15% fall in FEV1 (allergen PC15) during allergen-induced early asthmatic response (EAR) was assessed multicenter, randomized, double-blind, parallel group study. Ten 11 allergic subjects randomized to receive...
Although asthma is a chronic disease, the expected rate of spontaneous remissions adult and stability diagnosis are unknown.To determine whether current could be ruled out medications safely stopped in randomly selected adults with physician-diagnosed asthma.A prospective, multicenter cohort study was conducted 10 Canadian cities from January 2012 to February 2016. Random digit dialing used recruit participants who reported history established within past 5 years. Participants using...
<b>GINA no longer recommends treating adults/adolescents with asthma short-acting bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily corticosteroid-containing inhaler, to reduce risk of severe exacerbations.</b>http://bit.ly/310LLzE
BACKGROUND: In 2010, the Canadian Thoracic Society (CTS) published a Consensus Summary for diagnosis and management of asthma in children six years age older, adults, including an updated Asthma Management Continuum. The CTS Clinical Assembly subsequently began formal clinical practice guideline update process, focusing, this first iteration, on topics controversy and/or gaps previous guidelines. METHODS: Four questions were identified as focus guideline: role noninvasive measurements airway...