A5017520150- Amyotrophic Lateral Sclerosis Research
- Diabetes Management and Research
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Diabetes Treatment and Management
- Genetic Neurodegenerative Diseases
- Diabetes Management and Education
- Neurological diseases and metabolism
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- Obesity and Health Practices
- Alzheimer's disease research and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Neuroimaging Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced MRI Techniques and Applications
- Monetary Policy and Economic Impact
- Diet, Metabolism, and Disease
- Fiscal Policy and Economic Growth
- Cerebral Palsy and Movement Disorders
- Asthma and respiratory diseases
- Neurological disorders and treatments
University of Alberta
2016-2025
Bharti Hospital
2016-2025
Chandigarh University
1987-2025
Women and Children’s Health Research Institute
2016-2025
Mayo Clinic in Arizona
2020-2025
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Christian Medical College & Hospital
2022-2024
Indraprastha Apollo Hospitals
2024
Saifee Hospital
2024
Inhaled allergens, acting through IgE-dependent mechanisms, are important triggers of asthma symptoms and inducers airway hyperresponsiveness inflammation. The effect anti-IgE recombinant humanized monoclonal antibody-E25 (rhuMAb-E25) on the provocation concentration allergen causing a 15% fall in FEV1 (allergen PC15) during allergen-induced early asthmatic response (EAR) was assessed multicenter, randomized, double-blind, parallel group study. Ten 11 allergic subjects randomized to receive...
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand pharmacology. Herein, we report the pharmacology SAR studies both vitro vivo of mitragynine pseudoindoxyl (3), an oxidative rearrangement product corynanthe alkaloid mitragynine. 3 its corresponding corynantheidine analogs show promise potent analgesics a mechanism action that...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by degeneration of upper motor neurons (UMN) arising from the cortex in brain and lower (LMN) brainstem spinal cord. Cerebral changes create differences activity captured functional magnetic resonance imaging (fMRI), including spontaneous simultaneous occurring between regions known as resting state networks (RSNs). Progressive neurodegeneration observed ALS may lead to disruption RSNs which could provide...
KEY POINTS Amyotrophic lateral sclerosis (ALS) is a debilitating, progressive disease with degeneration of motor neurons in the brain and spinal cord causing weakness, muscle atrophy, fasciculations spasticity.[1][1] Onset limbs, extremity weakness impairment mobility,
RILUZOLE, a glutamate antagonist, has been shown to be efficacious in the treatment of patients with amyotrophic lateral sclerosis (ALS), allowing prolonged survival and time tracheostomy. The efficacy riluzole thought result from reduced excitotoxicity on motor neurons ALS, but this never demonstrated directly vivo. N-acetylaspartate (NAA), compound that is readily measured vivo using proton magnetic resonance spectroscopy, can used as surrogate marker for neuronal loss or sublethal injury....
Abstract Introduction Currently, there are no tools that can accurately predict which patients with mild cognitive impairment (MCI) will progress to Alzheimer's disease (AD). Texture analysis uses image processing and statistical methods identify patterns in voxel intensities cannot be appreciated by visual inspection. Our main objective was determine whether MRI texture could used conversion of MCI AD. Methods A method 3‐dimensional, whole‐brain compute features from T1‐weighted MR images....
<h3>Objective</h3> To evaluate progressive white matter (WM) degeneration in amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> Sixty-six patients with ALS and 43 healthy controls were enrolled a prospective, longitudinal, multicenter study the Canadian Neuroimaging Consortium (CALSNIC). Participants underwent harmonized neuroimaging protocol across 4 centers that included diffusion tensor imaging (DTI) for assessment of WM integrity. Three visits accompanied by clinical assessments...
Palladium is a versatile catalyst, but the synthesis of palladium nanoparticles (PdNPs) usually attained at high temperature in range 160 °C to 200 using toxic reducing agents such as sodium borohydride. We report PdNPs low-cost and environmentally-friendly route ambient temperatures. Quercetin diphosphate (QDP), naturally-derived flavonoid, was employed reducing, capping, stabilizing agent. The effect optimized produce perfectly spherical PdNP with sizes ranging from 0.1 0.3 microns...
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as pain reliever and for attenuation opioid withdrawal symptoms. Using the tools natural products chemistry, chemical synthesis, pharmacology, we provide detailed in vitro vivo pharmacological characterization alkaloids kratom. We report that metabolism kratom's major alkaloid, mitragynine, mice leads formation (a) potent mu receptor agonist antinociceptive agent, 7-hydroxymitragynine, through...
Alzheimer's disease is the most prevalent neurodegenerative disorder characterized by degeneration of brain. It classified as a brain causing dementia that presents with memory loss and cognitive impairment. Experts primarily use imaging other tests to rule out disease. To automatically detect patients from healthy controls, this study adopts vision transformer architecture, which can effectively capture global or long-range relationship image features. further enhance network's performance,...