A5036017418- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Allergic Rhinitis and Sensitization
- Particle accelerators and beam dynamics
- Pediatric health and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Pain Management and Treatment
- Eosinophilic Esophagitis
- Peptidase Inhibition and Analysis
- Neuroscience of respiration and sleep
- Air Quality and Health Impacts
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacological Effects and Assays
- Pharmaceutical studies and practices
- Delphi Technique in Research
- Emergency and Acute Care Studies
- IL-33, ST2, and ILC Pathways
- School Health and Nursing Education
- Particle Accelerators and Free-Electron Lasers
- Pleural and Pulmonary Diseases
University of Toronto
2016-2025
Toronto General Hospital
1997-2025
University Health Network
2015-2024
University of Vermont
2024
Toronto Western Hospital
2014-2023
Atomic Weapons Establishment
2023
Texas Christian University
2022
The Spine Institute
2022
Pain Management Institute
2022
Translational Research Institute
2021
Most guidelines recommend either a long-acting beta-agonist (LABA) plus an inhaled glucocorticoid or muscarinic antagonist (LAMA) as the first-choice treatment for patients with chronic obstructive pulmonary disease (COPD) who have high risk of exacerbations. The role LABA-LAMA regimen in these is unclear.We conducted 52-week, randomized, double-blind, double-dummy, noninferiority trial. Patients had COPD history at least one exacerbation during previous year were randomly assigned to...
Background: Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations inhaled corticosteroids, long-acting β-agonists, and anticholinergic bronchodilators is common but unstudied. Objective: To determine whether combining tiotropium salmeterol fluticasone–salmeterol improves clinical outcomes in adults to COPD compared alone. Design: Randomized, double-blind, placebo-controlled trial conducted from October 2003 January 2006. Setting: 27 academic community...
Exhaled nitric oxide (NO) may aid in monitoring pulmonary disease. The single-breath NO profile (subjects with nose clip) was described as a peak followed by plateau (NO(PLAT)). Published exhaled values vary greatly, possibly due to contamination nasal and differing respiratory maneuvers. We developed technique measure NO, without having the subject maintain positive expiratory pressure (ensuring vellum closure), we examined variation NO(PLAT) over range of flows (4.2 1,550 ml/s). rose...
Inhaled allergens, acting through IgE-dependent mechanisms, are important triggers of asthma symptoms and inducers airway hyperresponsiveness inflammation. The effect anti-IgE recombinant humanized monoclonal antibody-E25 (rhuMAb-E25) on the provocation concentration allergen causing a 15% fall in FEV1 (allergen PC15) during allergen-induced early asthmatic response (EAR) was assessed multicenter, randomized, double-blind, parallel group study. Ten 11 allergic subjects randomized to receive...
Telephone surveys describing suboptimal asthma control may be biased by low response rates. In order to obtain an unbiased assessment of and assess its impact in primary care, care physicians used a 1-page questionnaire 50 consecutive patients. Of the 10,428 patients assessed 354 physicians, 59% were uncontrolled, 19% well-controlled 23% totally controlled. Physicians overestimated control, regarding only 42% as uncontrolled. more likely report plans alter regimens uncontrolled than...
There is limited data on the risk factors and phenotypical characteristics associated with spirometrically confirmed COPD in never-smokers general population.To compare by gender severity of airway obstruction ever-smokers.We analysed from 5176 adults aged 40 years older who participated initial cross-sectional phase population-based, prospective, multisite Canadian Cohort Obstructive Lung Disease study. Never-smokers were defined as those a lifetime exposure <1/20 pack year. Logistic...
There are no studies on withdrawal of inhaled corticosteroids in patients long-term triple therapy the absence frequent exacerbations.To evaluate efficacy and safety direct de-escalation from to indacaterol/glycopyrronium nonfrequently exacerbating with chronic obstructive pulmonary disease (COPD).This 26-week, randomized, double-blind, triple-dummy study assessed change (110/50 μg once daily) or continuation (tiotropium [18 μg] daily plus combination salmeterol/fluticasone propionate...
Rationale: Studies of excised lungs show that significant airway attrition in the “quiet” zone occurs early chronic obstructive pulmonary disease (COPD).Objectives: To determine if total number airways quantified vivo using computed tomography (CT) reflects airway-related changes and is associated with lung function decline independent emphysema COPD.Methods: Participants multicenter, population-based, longitudinal CanCOLD (Canadian Chronic Obstructive Lung Disease) study underwent...
BACKGROUND: Two Canadian studies showed that 55% of patients with asthma had daily symptoms (in 1996) and 57% suffered from poorly controlled 1999). OBJECTIVES: To assess the state control adult Canadians, knowledge practices physicians actively involved in care asthma. METHODS: Telephone interviews were conducted adults 18 to 54 years age who been diagnosed at least six months before survey, did not have chronic obstructive pulmonary disease a smoking history fewer than 20 pack‐years....
Chronic exposure to traffic-related air pollution (TRAP) may contribute premature mortality, but few studies date have addressed this topic.In study we assessed the association between TRAP and mortality in Toronto, Ontario, Canada.We collected nitrogen dioxide samples over two seasons using duplicate two-sided Ogawa passive diffusion samplers at 143 locations across Toronto. We calibrated land use regressions predict NO2 on a fine scale within used interpolations levels of particulate...
BACKGROUND: Several sets of Canadian guidelines for the diagnosis and management asthma have been published over past 15 years. Since last revision 1999 Asthma Consensus Report, important new studies highlighted need to incorporate information into guidelines. OBJECTIVES: To review literature on adult between January 2000 June 2003; evaluate influence evidence recommendations made in Guidelines its 2001 update; report management. METHODS: Three specific topics which affected previous were...
Relapse after the treatment of acute asthma in emergency room is common (occurring 25 to 30 percent cases) and not accurately predicted by any available measurements. We studied usefulness prednisone reducing this high rate relapse.One hundred twenty-two patients treated for exacerbations were assigned a randomized, double-blind fashion receive at discharge either eight days (the dose being tapered from 40 0 mg per day) or matching placebo. Ninety-three subsequently discharged participated...