Andriana Ι. Papaioannou
A5010301737- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Esophagitis
- Pleural and Pulmonary Diseases
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Obstructive Sleep Apnea Research
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Occupational and environmental lung diseases
- Pharmaceutical studies and practices
- Occupational exposure and asthma
- Ultrasound in Clinical Applications
- Nutrition and Health in Aging
National and Kapodistrian University of Athens
2016-2025
Sotiria General Hospital
2022-2025
e-Trikala (Greece)
2024
Respiratory Clinical Trials
2023
University General Hospital Attikon
2015-2022
Centre Eugène Marquis
2022
Université de Rennes
2022
Inserm
2022
Sismanoglio General Hospital
2011-2021
Translational Research Institute
2021
Pulmonary rehabilitation (PR) remains grossly underutilised by suitable patients worldwide. We investigated whether home-based maintenance tele-rehabilitation will be as effective hospital-based and superior to usual care in reducing the risk for acute chronic obstructive pulmonary disease (COPD) exacerbations, hospitalisations emergency department (ED) visits. Following completion of an initial 2-month PR programme this prospective, randomised controlled trial (between December 2013 July...
Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe cohorts.What is the prevalence phenotypes population asthma, can these be differentiated by clinical biomarker variables?This was an historical registry study. Adult available blood eosinophil count (BEC) from 11 countries enrolled International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood phenotype...
Abstract Sirtuin-1 (SIRT1) and SIRT6, NAD + -dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of lung associated increased oxidative stress. Here, we show that stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not related miR-34b/c, concomitant reduction SIRT1/-6 bronchial epithelial cells (BEAS2B), was also observed...
International registries provide opportunities to describe use of biologics for treating severe asthma in current clinical practice. Our aims were real-life global patterns biologic (continuation, switches, and discontinuations) asthma, elucidate reasons underlying these patterns, examine associated patient-level factors.This was a historical cohort study including adults with enrolled into the Severe Asthma Registry (ISAR; http://isaregistries.org, 2015-2020) or CHRONICLE Study (2018-2020)...
Previous studies investigating the impact of comorbidities on effectiveness biologic agents have been relatively small and short duration not compared classes agents.
COPD is a major healthcare problem and cause of mortality worldwide. patients at increased risk are those who more symptomatic, have lower lung function diffusing capacity the for carbon monoxide, decreased exercise capacity, belong to emphysematous phenotype concomitant bronchiectasis. Mortality seems be greater in experience exacerbations suffer from cardiovascular and/or metabolic diseases. To predict death patients, several composite scores been created using different parameters. In...
Background To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers assessment of biologic efficacy from structured clinical trials. Aim elucidate associations individual or their combinations with pre-to-post changes in asthma real-life. Methods This was a registry-based, cohort study using data 23 countries, which shared International Severe Asthma Registry (May 2017-February 2023). The...
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As first global registry for adults with asthma, ISAR enabled individual registries standardize pool their data, creating a comprehensive, harmonized dataset sufficient statistical power address key research questions knowledge gaps. Today, is largest repository real-world data on curating nearly 35,000 patients...
Serum uric acid is increased in respiratory disease, especially the presence of hypoxia and systemic inflammation. We evaluated serum as a biomarker for prediction mortality future acute exacerbation chronic obstructive pulmonary disease (AECOPD). was measured 314 eligible consecutive patients on admission AECOPD. Patients were monthly 1 year. Uric levels higher with more severe airflow limitation those experiencing frequent exacerbations. High (≥6.9 mg·dL(-1)) an independent predictor...
According to induced sputum cell count, four different asthma phenotypes have been recognized (eosinophilic, neutrophilic, mixed and paucigranulocytic). The aim of this study was detect functional inflammatory characteristics patients with paucigranulocytic asthma.A total 240 asthmatic were categorized into the according counts in sputum. All underwent pulmonary function tests, measurement fraction exhaled nitric oxide (FeNO). levels IL-8, IL-13 eosinophilic cationic protein (ECP) also...
The impact of depressive symptoms on outcomes acute exacerbations chronic obstructive pulmonary disease (AECOPD) has not been thoroughly evaluated in prospective studies. We prospectively enrolled 230 consecutive patients hospitalised for AECOPD, without previous diagnosis depression. Depressive were with Beck's depression inventory. Pulmonary function tests, arterial blood gases, COPD assessment test (CAT) and Borg dyspnoea scale recorded admission days 3, 10 40. Patients monthly 1 year....
Idiopathic pulmonary fibrosis acute exacerbation (IPF-AE) constitutes IPF's most devastating event, representing the unexpected superimposition of diffuse alveolar damage unknown etiology. Guidelines recommend high-dose steroids treatment despite unproven benefit. We hypothesized that previous immunosuppression and administration adversely affect IPF-AE outcome. studied all consecutive patients hospitalized in our department for IPF deterioration from 2007 to June 2013. Our protocol...
BackgroundInvestigation for the presence of asthma comorbidities is recommended by GINA as their can complicate management.ObjectiveTo understand prevalence and pattern multimorbidity in adults with severe association asthma-related outcomes.MethodsThis was a cross-sectional study using data from International Severe Asthma Registry 22 countries. Thirty were identified categorized priori either (1) potentially T2-related, (2) oral corticosteroid (OCS)-related or (3) mimicking/aggravating...
BACKGROUND Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS), nor compared to effectiveness continuing HOCS alone. OBJECTIVE To examine the initiating a large, real-world cohort adult severe asthma and HOCS. METHODS This was propensity-score-matched, prospective study using data from International Severe Asthma Registry (http://isaregistries.org/). Between January 2015 February 2021, (long-term OCS ≥1 year or ≥4 courses rescue...
Evidence from large epidemiological studies has shown that obesity may predispose to increased Th2 inflammation and increase the odds of developing asthma. On other hand, there is growing evidence suggesting metabolic dysregulation occurs with obesity, more specifically hyperglycemia insulin resistance, modify immune cell function in some degree systemic inflammation. Insulin resistance seldom on its own, most cases constitutes a clinical component syndrome, along central dyslipidemia....
Pleural effusion is a common complication of various diseases. Conventional methods are not always capable establishing the cause pleural effusion, so alternative tests needed. The aim this study was to explore means discriminating between different groups, malignant, parapneumonic and tuberculous, based on combined function seven biological markers. Adenosine deaminase (ADA), interferon-γ, C-reactive protein (CRP), carcinoembryonic antigen, interleukin-6, tumour necrosis factor-α vascular...
The association between systemic sclerosis and pulmonary arterial hypertension (PAH) is well recognized. Vascular endothelial growth factor (VEGF) has been reported to play an important role in hypertension. aim of the present study was examine relationship systolic artery pressure, clinical functional manifestations disease serum VEGF levels sclerosis. Serum were measured 40 patients with 13 control subjects. All underwent examination, function tests echocardiography. higher sPAP ≥ 35 mmHg...