A5050770042- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
- Eosinophilic Disorders and Syndromes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Emergency and Acute Care Studies
- Obstructive Sleep Apnea Research
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Human Health and Disease
Tan Tock Seng Hospital
2013-2024
BackgroundExacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous.ObjectiveWe sought to investigate the sputum cellular, mediator, microbiome profiles both COPD exacerbations.MethodsPatients with severe or moderate-to-severe were recruited prospectively a single center. Sputum mediators available in 32 asthmatic patients 73 assessed at exacerbation. Biologic clusters determined by using factor cluster analyses on panel mediators. Patterns clinical...
Background To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers assessment of biologic efficacy from structured clinical trials. Aim elucidate associations individual or their combinations with pre-to-post changes in asthma real-life. Methods This was a registry-based, cohort study using data 23 countries, which shared International Severe Asthma Registry (May 2017-February 2023). The...
Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare sputum serum inflammatory profiles in moderate-to-severe asthma during stable exacerbation events.We recruited 102 adults 34 children with asthma. The were assessed at baseline, 3, 6, 12-month follow-up visits. Thirty-seven subjects onset severe exacerbation. Forty mediators 43 measured. Receiver-operator characteristic (ROC) curves constructed...
Abstract Background and Objective While the lung microbiome in severe asthma has been studied, work employed targeted amplicon‐based sequencing approaches without functional assessment with none focused on multi‐ethnic Asian populations. Here we investigate clinical relevance of microbial phenotypes Asians using metagenomics. Methods Prospective clinical, radiological, immunological measures were performed a cohort ( N = 70) recruited across two centres Singapore. Sputum was subjected to...
<b>Background:</b> Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous. <b>Objective:</b> To investigate sputum cellular, mediator microbiome profiles COPD exacerbations. <b>Methods:</b> Patients with severe or moderate-to-severe were prospectively recruited to a single centre. Sputum mediators available in 32 73 patients at exacerbation. Biologic clusters determined using factor cluster analyses on panel mediators. Patterns clinical parameters,...
<b>Introduction:</b> While the lung microbiome in severe asthma (SA) has been characterized, there remains a lack of metagenomic studies Asian cohorts. <b>Methods:</b> Patients with SA (N=70) were prospectively recruited, clinical data collated, and sputum samples subjected to deep shotgun sequencing evaluate microbiomes. followed up for two consecutive years exacerbations requiring steroid bursts, emergency room visits and/or hospitalization recorded. <b>Results:</b> Median age cohort was...
This work was supported by Asthma UK [08/11], the Medical Research Council [grant number MR/J00345X/1], Wellcome Trust 098351/Z/12/Z], Cambridge NIHR Biomedical Centre, Senior Fellowship (to CEB) WT082265], AirPROM 7th EU Framework grant and Leicester Centre.
Asthma is a common respiratory condition seen in primary care.It characterised by symptoms and variable expiratory airflow limitation due to underlying chronic airway inflammation.Diagnosis should be established promptly prevent misdiagnosis inappropriate management.Objective lung function assessment therefore recommended guide the care physician.This article describes use of spirometry, its role diagnosis asthma control.Barriers spirometry are also discussed with suggested interventions.
<b>Background/Aims:</b> Asthma exacerbations needing emergency department (ED) treatment pose a burden on the healthcare system. As many are related to poor compliance, patient counseling and prescription of ICS might reduce reattendances. We aimed study impact asthma nurse-led counselling ED practices reduction 30-day (30d) <b>Methods:</b> conducted 9-year retrospective multicentre, observational in 2 academic hospitals Singapore. All adult patients with an exacerbation presenting were...
plethysmography; dynamic ultrasound evaluation of postural stability; respiratory rehabilitation (Tx) as recommended by ERS [DOI: 10.