A5107503516- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Neuroscience of respiration and sleep
- Pneumonia and Respiratory Infections
- Lipoproteins and Cardiovascular Health
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Lipids, and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
- Nursing Diagnosis and Documentation
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Antimicrobial Peptides and Activities
- Helicobacter pylori-related gastroenterology studies
- Chronic Disease Management Strategies
- Neonatal Respiratory Health Research
- Sleep and Wakefulness Research
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2015-2025
Kyoto University
2021
National Taipei University
2004-2021
Kaohsiung Veterans General Hospital
2019
Kaohsiung Medical University
2019
National Taiwan University
2019
National Yang Ming University Hospital
2013-2017
University of Taipei
2013
American College of Chest Physicians
2008
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As first global registry for adults with asthma, ISAR enabled individual registries standardize pool their data, creating a comprehensive, harmonized dataset sufficient statistical power address key research questions knowledge gaps. Today, is largest repository real-world data on curating nearly 35,000 patients...
Background To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers assessment of biologic efficacy from structured clinical trials. Aim elucidate associations individual or their combinations with pre-to-post changes in asthma real-life. Methods This was a registry-based, cohort study using data 23 countries, which shared International Severe Asthma Registry (May 2017-February 2023). The...
ABSTRACT Background and Objective Symptom‐based questionnaires handheld lung function devices are widely used for COPD case finding, but the optimal combination remains unclear. This study aimed to compare diagnostic accuracy (DA) of various combinations develop a case‐finding strategy. Methods cross‐sectional, prospective, observational enrolled participants aged ≥ 40 years with respiratory symptoms 10 smoking pack‐years. Participants completed three (COPD questionnaire [CDQ],...
Airway remodeling with smooth muscle cell (SMC) hyperplasia is a feature of chronic asthma. We investigated the potential for tryptase, major secretory product human mast cells, to act as growth factor airway SMCs. Because this serine protease can activate proteinase-activated receptor-2 (PAR-2), we also examined actions SLIGKV, peptide agonist PAR-2. Incubation lung tryptase provoked twofold increase in [ 3 H]thymidine incorporation; similar numbers was found when used MTS assay. The effect...
Asthmatic patients have higher numbers of mast cells in the smooth muscle layer airways than normal subjects. Human airway (HASMCs) are a source various cytokines including transforming growth factor beta1 (TGF-beta1), which is chemotactic for cells. We thus examined potential interaction between HASMCs and investigated, particular, hypothesis that after stimulation, can induce cell chemotaxis through production cytokines. Supernatants treated with major product tryptase had increased...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposed a new severity assessment system emphasizing clinical symptom evaluation by COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scores. aim of the study was to evaluate effectiveness two scoring systems in evaluating patients. A population based cross-sectional employing computer-assisted telephone interviewing (CATI) surveying epidemiology Taiwan. Among 6600 subjects recruited (age >...
BACKGROUND Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS), nor compared to effectiveness continuing HOCS alone. OBJECTIVE To examine the initiating a large, real-world cohort adult severe asthma and HOCS. METHODS This was propensity-score-matched, prospective study using data from International Severe Asthma Registry (http://isaregistries.org/). Between January 2015 February 2021, (long-term OCS ≥1 year or ≥4 courses rescue...
Abstract Allergenic serine proteases are important in the pathogenesis of asthma. One these, Pen c 13, is immunodominant allergen produced by Penicillium citrinum. Many induce cytokine expression, but whether 13 does so human respiratory epithelial cells not known. In this study, we investigated caused IL-8 release and activated protease-activated receptors (PARs) airway cells. airway-derived A549 normal cells, induced a dose-dependent manner. also increased time-dependent manner cleaved...
Summary Sleep disorders are common non‐motor symptoms in patients with Parkinson's disease. Our study aims to explore the relationship between non‐apnea sleep and future This is a cohort using nationwide database. The participants were recruited from Taiwan National Health Insurance Research Database 2000 2003. A total of 91 273 adult who had without pre‐existing disease enrolled. An age‐, gender‐, income‐, urbanization‐ Charlson comorbidity index score‐matched control consisting was...
Cysteinyl leukotrienes (CysLTs) play an important role in the pathogenesis of airway remodeling. We investigated interaction between epithelium and CysLTC4, contribution this to fibrosis. Human epithelial cells were grown on air-liquid interface culture inserts. CysLTC4 was employed stimulate cells. Conditioned medium following stimulation coincubated with human lung fibroblasts. Our results have demonstrated that stimulates cells, through a p38 mitogen-activated protein kinase (MAPK)...
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a major in Asia. However, how to manage specifically Asian COPD patients has not been proposed. Awareness of very low and underdiagnosis/undertreatment common countries. Low utilization function test inhalers also problem. Moreover, high smoking prevalence air pollution are barriers managing with COPD. The relatively body mass index can increase their risk for experiencing adverse effects from drugs. Physicians should consider the...
Background: REMIT is the first real-world study of mepolizumab effectiveness in patients with severe asthma (SA) Taiwan. Objectives: The primary objective evaluated changes clinically significant exacerbations (CSEs; defined as use oral corticosteroids (OCS) or emergency department (ED) visits and/or hospitalizations) 12 months pre- and post-mepolizumab treatment. Secondary objectives assessed number CSEs requiring ED visits/hospitalizations daily maintenance OCS (mOCS) dosage Three-...
Background: Pulmonary function tests offer crucial parameters for evaluating lung health and predicting clinical outcomes. Hyperlipidemia, a prevalent metabolic disorder, has been linked to declining pulmonary function. Statins are an essential therapy lowering lipid levels in hyperlipidemia. Objectives: This study aims investigate the therapeutic potential of statins mitigating decline Design: is retrospective cohort study. Methods: Out 8286 patients who underwent spirometry testing from...
Small airway dysfunction (SAD) is prevalent in asthma and chronic obstructive pulmonary disease (COPD). Aging acknowledged to be associated with the loss of small structures. However, impact aging pathophysiological changes on SAD COPD remains unclear. We aimed investigate entity change-related assessed by spirometry impulse oscillometry (IOS). retrospectively reviewed adult patients diagnosed or between May 2017 August 2021 Taipei Veterans General Hospital. Treatment-naïve aged ≥60 years...
The independent risk factors for death in patients admitted asthma exacerbation have not been thoroughly investigated. This study aimed to investigate these and the relationship between mortality prescription patterns of anti-asthmatic medications exacerbation. Using a nested case-control design, we identified 267 cases (death after admission) 1035 controls (survival from Taiwan National Health Insurance Research Database (NHIRD) 2001 2010. Conditional logistic regressions were used estimate...
Abstract We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma chronic obstructive pulmonary disease (ACO). A total 75 228 COPD patients were identified as ACO, which was independently associated with increased exacerbations. Microarray analysis 404 differentially methylated loci (DML) in ACO patients, 6575 DML those rapid lung function decline discovery cohort. In validation cohort, had hypermethylated PDE9A (+ 30,088)/ ZNF323 (− 296),...