A5039311266- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Peptidase Inhibition and Analysis
- Nosocomial Infections in ICU
- Obstructive Sleep Apnea Research
- Tuberculosis Research and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Pneumonia and Respiratory Infections
- Toxic Organic Pollutants Impact
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Mosquito-borne diseases and control
- Neuroscience of respiration and sleep
- Immune Response and Inflammation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
Kaohsiung Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Kaohsiung Medical University
2009-2025
Chang Gung University of Science and Technology
2014-2024
National Sun Yat-sen University
2024
Chang Gung Memorial Hospital
2007-2023
Linkou Chang Gung Memorial Hospital
2022
China Medical University
2021
China Medical University Hospital
2021
Memorial Hospital of South Bend
2009-2021
Aumolertinib (formerly almonertinib; HS-10296) is a novel third-generation EGFR tyrosine kinase inhibitor (TKI) with revealed activity against EGFR-sensitizing mutations and T790M mutation.Patients locally advanced or metastatic NSCLC who developed an mutation after progression on first- second-generation TKI therapy were enrolled in this registrational phase 2 trial of aumolertinib at 110 mg orally once daily (NCT02981108). The primary end point was objective response rate (ORR) by...
Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi. Acute respiratory distress syndrome (ARDS) serious complication of scrub typhus. This study retrospectively reviewed the medical records 72 patients diagnosed with from January 1998 to August 2006 in Kaohsiung Chang Gung Memorial Hospital Taiwan. Eight ARDS were included study; other without used as controls. The mortality rate for was 25%. eight seldom had underlying diseases. Initial presentations dyspnea and...
Abstract The association between sepsis and segmented neutrophil-to-monocyte (SeMo) ratio is unclear. We postulated that an increase in dynamic SeMo measurement can be applied risk stratification. This retrospective study included 727 consecutive patients medical intensive care units (ICUs), including a subpopulation of 153 patients. According to the leukocyte (white blood cell, WBC) count on day 3 (normal range, 4,000/µL 12,000/µL) delta (value minus value 1; normal SeMo, <7), were...
Importance Arginine deprivation using ADI-PEG20 (pegargiminase) combined with chemotherapy is untested in a randomized study among patients cancer. ATOMIC-Meso (ADI-PEG20 Targeting of Malignancies Induces Cytotoxicity-Mesothelioma) pivotal trial comparing standard first-line plus pegargiminase or placebo nonepithelioid pleural mesothelioma. Objective To determine the effect pegargiminase-based on survival mesothelioma, an arginine-auxotrophic tumor. Design, Setting, and Participants This was...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposed a new severity assessment system emphasizing clinical symptom evaluation by COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scores. aim of the study was to evaluate effectiveness two scoring systems in evaluating patients. A population based cross-sectional employing computer-assisted telephone interviewing (CATI) surveying epidemiology Taiwan. Among 6600 subjects recruited (age >...
Real-world clinical experience with afatinib as a treatment for advanced lung adenocarcinoma harboring uncommon epidermal growth factor receptor (EGFR) mutations (G719X, L861Q and S768I) has rarely been reported. We aimed to perform retrospective multicenter study analyze therapy in untreated EGFR mutations. Between May 2014 June 2021, the data of 90 stage IIIB/IV patients (G719X/L861Q/S768I) treated first-line from cancer center database Linkou, Tucheng, Kaohsiung Chang Gung Memorial...
To compare the clinical and laboratory characteristics disease severity between adults children with dengue in Taiwan 2002, we retrospectively studied 661 serologically confirmed dengue-infected patients (606 55 children) admitted June December 2002 to a single medical centre. The charts of were reviewed for demographic, clinical, imaging information. Compared children, adult found have: higher incidences arthralgia (P<0.001), myalgia (P=0.002), headache (P=0.028), abdominal pain (P=0.004)...
Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns nephrotoxic of OPFRs yet to be investigated in patients chronic kidney disease (CKD). We conducted a cross-sectional study involving 166 CKD stratified by estimated glomerular filtration rate (eGFR) severity proteinuria. The urinary concentrations 10 OPFR compounds were measured evaluate patterns. Clinical...
To investigate clinical course and outcome of dengue with acute respiratory failure (ARF), to identify related risk factors for acquiring ARF in dengue, we retrospectively studied 11 patients ARF. From June December 2002, a total 606 adult were diagnosed as having dengue. Eleven (1.8%) had complications The main causes sepsis (n = 6, 54.5%) upper gastrointestinal (UGI) bleeding 3, 27.3%). mortality rate was 72.7% 8). Additionally, univariate analysis showed that age, dyspnea, cough,...
Background . Endothelial-derived microparticles (EDMPs) and platelet-derived (PDMPs) have been reported to be increasing in various diseases including malignant diseases. Here, we investigated whether these MPs may useful biomarkers for predicting lung cancer (LC) disease status, cell type, or metastasis. Methods Results One hundred thirty LC patients were prospectively enrolled into the study between April 2011 February 2012. Flow cytometric analysis demonstrated that circulating levels of...
Background Patients with early-stage lung cancer who have a high baseline lymphocyte-to-monocyte ratio (LMR) favorable prognosis. However, the prognostic significance of LMR in patients advanced-stage EGFR-mutant non-small cell (NSCLC) receiving first-line epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) has not been established. We conducted retrospective analysis to investigate influence on clinical outcomes including progression-free survival (PFS) and overall...
Background . This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC). Methods and Results One hundred seven were prospectively enrolled into between April 2011 February 2012, each patient received regular follow-up after enrollment. Levels of four MPs circulation, (1) platelet-derived activated (PDAc-MPs), (2) apoptotic (PDAp-MPs), (3) endothelial-derived...
Purpose: A low body mass index (BMI) is a poor prognostic marker of acute exacerbations and mortality in patients with COPD. However, the impact overweight obesity on COPD-related outcomes uncertain. The aim this study was to examine whether high BMI associated frequent exacerbator phenotype (≥2/year) Taiwanese Patients methods: Data were obtained from Taiwan Obstructive Lung Disease study, retrospective, observational nationwide survey COPD conducted at 12 hospitals Taiwan. Multivariate...
Background Treatment for stage III non‐small cell lung cancer (NSCLC) of unresectable disease mainly involves concurrent chemoradiation (CRT). Post‐CRT consolidation treatment with durvalumab is a major therapeutic advance that provides survival benefit in this group patients. However, the performance strategy remains to be studied real‐world setting. Methods A total 31 patients who had control post‐CRT were included early access program (EAP) as an intent‐to‐treat cohort and retrospectively...
Abstract KEYNOTE‐033 (NCT02864394) was a multicountry, open‐label, phase 3 study that compared pembrolizumab vs docetaxel in previously treated, programmed death‐ligand 1 (PD‐L1)‐positive, advanced non‐small cell lung cancer (NSCLC), with most patients enrolled mainland China. Eligible were randomized (1:1) to 2 mg/kg or 75 mg/m every weeks. Primary endpoints overall survival (OS) and progression‐free evaluated sequentially using stratified log‐rank tests, first PD‐L1 tumor proportion score...
Currently, the clinical outcomes of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) baseline brain metastasis receiving first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs) are not clear. The present study aimed to assess EGFR-mutated NSCLC who received first-line EGFR-TKIs. In study, a retrospective analysis charts was performed investigate EGFR-TKIs in metastasis. Data from 197 gefitinib, erlotinib or afatinib between May 2013...
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety nemonoxacin compared levofloxacin patients CAP.A phase 3, multicenter, randomized (2:1) controlled trial conducted adult CAP receiving 500 mg or orally once daily for 7-10 days. Clinical, microbiological response adverse events were assessed....
Background Sepsis-induced immune dysfunction ranging from cytokines storm to immunoparalysis impacts outcomes. Monitoring enables better risk stratification and mortality prediction is mandatory before widely application of immunoadjuvant therapies. We aimed develop validate a scoring system according patients' status for 28-day prediction. Methods A prospective observational study cohort adult sepsis patients admitted ICU between August 2013 June 2016 at Kaohsiung Chang Gung Memorial...