A5074784103- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Medical Imaging Techniques and Applications
- Asthma and respiratory diseases
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Pleural and Pulmonary Diseases
China Medical University
2016-2025
China Medical University Hospital
2016-2025
China Medical University
2007-2024
Asia University
2023
Chung Shan Medical University Hospital
2020
Chiayi Chang Gung Memorial Hospital
2019
National Yang Ming Chiao Tung University
2018
National Chung Hsing University
2018
First Affiliated Hospital of Xi'an Jiaotong University
2017
Bridge University
2016
PURPOSE Pembrolizumab monotherapy is standard first-line therapy for metastatic non–small-cell lung cancer (NSCLC) with programmed death ligand 1 (PD-L1) tumor proportion score (TPS) ≥ 50% without actionable driver mutations. It not known whether adding ipilimumab to pembrolizumab improves efficacy over alone in this population. METHODS In the randomized, double-blind, phase III KEYNOTE-598 trial (ClinicalTrials.gov identifier: NCT03302234 ), eligible patients previously untreated NSCLC...
Several studies have shown that gallic acid (GA) induces apoptosis in different cancer cell lines, whereas the mechanism of action GA-induced at molecular level human non-small-cell lung NCI-H460 cells is not well-known. Here, GA decreasing percentage viable was investigated; involved G2/M phase arrest and intracellular Ca(2+) production, loss mitochondrial membrane potential (DeltaPsi(m)), caspase-3 activation. The efficacious induction DNA damage observed 50-500 microM for 24 and/or 48 h...
This study assesses different technologies for detecting epidermal growth factor receptor (EGFR) mutations from circulating tumor DNA in patients with EGFR T790M-positive advanced non-small cell lung cancer (NSCLC) the AURA3 (NCT02151981), and it evaluates clinical responses to osimertinib platinum-pemetrexed according plasma T790M status.Tumor tissue biopsy samples were tested during screening cobas Mutation Test (cobas tissue). Plasma collected at baseline retrospectively analyzed v2...
Aumolertinib (formerly almonertinib; HS-10296) is a novel third-generation EGFR tyrosine kinase inhibitor (TKI) with revealed activity against EGFR-sensitizing mutations and T790M mutation.Patients locally advanced or metastatic NSCLC who developed an mutation after progression on first- second-generation TKI therapy were enrolled in this registrational phase 2 trial of aumolertinib at 110 mg orally once daily (NCT02981108). The primary end point was objective response rate (ORR) by...
Abstract Purpose: The final analyses of the INSIGHT phase II study evaluating tepotinib (a selective MET inhibitor) plus gefitinib versus chemotherapy in patients with MET-altered EGFR-mutant NSCLC (data cut-off: September 3, 2021). Patients and Methods: Adults advanced/metastatic NSCLC, acquired resistance to first-/second-generation EGFR inhibitors, gene copy number (GCN) ≥5, MET:CEP7 ≥2, or IHC 2+/3+ were randomized 500 mg (450 active moiety) 250 once daily, chemotherapy. Primary endpoint...
Abstract Benzyl isothiocyanate (BITC) and phenethyl (PEITC), a member of the family, have been shown to exhibit antineoplastic ability against many human cancer cells. In this study, we found that exposure osteogenic sarcoma U‐2 OS cells BITC PEITC led induce morphological changes decrease percentage viable in time‐ dose‐dependent manner. induced cell cycle arrest at G2/M phase 48 h treatment inhibited levels regulatory proteins such as cyclin A B1 but promoted level Chk1 p53 arrest. marked...
Background/Aim: Matrix metalloproteinase-9 (MMP-9) expression is upregulated in various diseases, including lung cancer. However, the role of MMP-9 genotype cancer susceptibility remains uncertain. This study aimed to clarify contribution promoter rs3918242 genotypes risk Taiwan. Materials and Methods: The 358 patients 716 healthy controls were determined using polymerase chain reaction-restriction fragment length polymorphism methodology. Results: Individuals carrying variant CT or TT did...
Several studies have reported an association between chronic obstructive pulmonary disease (COPD) and periodontal diseases. However, a large-scale population-based cohort study was previously absent from the literature. Therefore, we evaluated risk of diseases in patients with COPD nationwide population. From National Health Insurance claims data Taiwan, identified 22,332 who were newly diagnosed during 2000 to 2010. For each case, two individuals without randomly selected frequency matched...
Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to compensatory PI3K/AKT activation and thus contributes desensitization of cells inhibitors. The underlying molecular mechanism this event is not yet understood. In study, our data showed that induction Akt activity by inhibitors was specifically observed in HER2-positive breast cells. Silence HER2, or overexpression HER2 kinase-dead mutant, prevents response inhibition,...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are standard of care for patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) common mutations (Del19 or L858R); however, 7%-23% NSCLC tumors harbor uncommon mutations. These highly heterogeneous, and developments in detection techniques helping to identify little no clinical data.
Background/Aim: In the literature, studies about role of matrix metalloproteinase-2 (MMP-2) in pterygium diagnosis are mainly based on its protein expression. The MMP-2 variants has never been examined. aim this study was to examine association genotypes with risk. Materials and Methods: rs243865 rs2285053 were genotyped 140 cases 280 non-pterygium controls by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping technology. Results: genotypic...
Over-expression of matrix metalloproteinase-1 (MMP-1) has been suggested as a biomarker for endometriosis. However, the genetic influence MMP-1 in pathogenesis endometriosis remains unclear, with its role yet to be fully elucidated. This study aimed investigate association between rs1799750 promoter polymorphisms and risk developing hospital-based case-control included 203 women diagnosed 636 age-matched controls. Genotyping polymorphism was conducted using polymerase chain...
Bufalin has been shown to be effective against a variety of cancer cells, but its role in lung never studied an animal model. In this study, we evaluated bufalin effects human cell line NCI-H460 both vitro and vivo. caused significant cytotoxicity cells at concentration as low 1 μM. DNA condensation was observed bufalin-treated dose-dependent manner. Mitochondrial membrane potential (ΔΨm ) reduced reactive oxygen species (ROS) were increased cells. Levels several proapoptotic proteins such...
Treatment of periodontal diseases has been associated with benefit outcomes for patients chronic obstructive pulmonary disease (COPD). However, no population-based cohort study conducted. We evaluated this relationship by retrospective using a large population data. Using the National Health Insurance claims data Taiwan, we identified 5562 COPD who had received treatment as group. The comparison group was selected at 1:1 ratio matched propensity score estimated age, sex, date diagnosis and...
Obese people have higher risk of respiratory symptoms. The relationship between obesity and lung function varies with age, race, geographical region. objective this study is to examine the effects body mass index on spirometric tests among adults in Xi'an city. This a cross-sectional study. Pulmonary testing was conducted participants recruited from Xi'an, China July August 2012. Force expiratory volume first second (FEV1), force vital capacity (FVC), FEV1/FVC, peak flow (PEF), forced at...
Glioblastoma is the most common primary malignant tumor of central nervous system, with an annual incidence 5.26 per 100000 people. The clinical outcome standard therapy and survival rate remain poor; therefore, there unmet need for a new strategy to treat this lethal disease. Although amentoflavone was known have anticancer potential in various types cancers, its antiglioblastoma ability mechanism unrecognized. We demonstrated that may suppress glioblastoma invasion migration by transwell...
Numerous studies have reported the over-expression of radiation-sensitive protein 51 (RAD51) in various types cancer. However, role RAD51 genotypes lung cancer remains largely unknown. This study aimed to assess impact common variant rs1801320 (G-135C) on risk Taiwan.