A5035962765- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Pain Management and Opioid Use
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- DNA Repair Mechanisms
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Carcinogens and Genotoxicity Assessment
- Pediatric Pain Management Techniques
- Cancer survivorship and care
- Healthcare Systems and Reforms
- Palliative Care and End-of-Life Issues
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Economic and Financial Impacts of Cancer
Hospital Kuala Lumpur
2020-2025
Beacon College
2024
Cancer Research Malaysia
2024
Sunway University
2019-2022
University of Malaya
2012-2014
University Malaya Medical Centre
2014
University of Glasgow
2010-2013
Beatson West of Scotland Cancer Centre
2005-2013
Cancer Research UK Scotland Institute
2010-2011
Western Infirmary
2006
Current management of locally advanced rectal cancer includes neoadjuvant chemoradiation in selected patients to increase the chance a tumour-free circumferential resection margin. There is uncertainty over role and selection criteria for additional systemic therapy this group patients. In retrospective study we investigate association between markers inflammatory response (SIR) outcome from treatment.One hundred fifteen with undergoing preoperative had recording full blood count parameters...
Abstract In order to implement more effective policies for cancer pain management, a better understanding of current practices is needed. Physicians managing and patients experiencing were randomly surveyed across 10 Asian countries assess attitudes perceptions toward management. A total 463 physicians (77.3% oncologists) with median experience 13 years included. Medical school training on opioid use was considered inadequate by 30.5% 55.9% indicated ≤10 h continuing medical education ( CME...
MET amplification (METamp), a mechanism of acquired resistance to EGFR tyrosine kinase inhibitors, occurs in up 30% patients with non-small-cell lung cancer (NSCLC) progressing on first-line osimertinib. Combining osimertinib inhibitor, such as tepotinib, an oral, highly selective, potent may overcome METamp-driven resistance. INSIGHT 2 (NCT03940703), international, open-label, multicenter phase II trial, assesses tepotinib plus advanced/metastatic EGFR-mutant NSCLC and METamp, determined...
9021 Background: METamp is a common resistance mechanism developed in patients (pts) with EGFRm NSCLC treated osimertinib. MET tyrosine kinase inhibitors (TKIs) such as tepotinib may be effective treating these pts after Here we report interim data from the INSIGHT 2 study evaluating + osimertinib previously Methods: In this open-label Phase II (INSIGHT 2, NCT03940703), advanced progression on 1L received 500 mg (450 active moiety) 80 once daily. was centrally detected tissue biopsy (TBx) by...
Background: The prevalence of undertreated cancer pain remains high. Suboptimal control affects quality life and results in psychological emotional distress. Barriers to adequate include fear opioid dependence its side effects. Aim: To investigate the attitudes perceptions morphine use advanced patients their caregivers examine influence caregivers’ on patients’ acceptance morphine. Design: Qualitative study involving semi-structured individual interviews transcribed verbatim analyzed...
Background: Afatinib can be started at a dose lower than the recommended starting of 40 mg/day for treatment epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), however outcomes in real-world clinical practice remains unclear.
Response rates of epidermal growth factor receptor (
The purpose of this study was to demonstrate how magnetic resonance imaging (MRI) patient position protocols influence registration quality in patients with oropharyngeal cancer undergoing radical radiotherapy and the consequences for gross tumour volume (GTV) definition planning.Twenty-two underwent a computed tomography (CT), diagnostic MRI (MRI(D)) an within immobilization mask (MRI(RT)). Clinicians delineated GTV on CT viewing MRI(D) separately (GTV(C)); registered (GTV(D)) MRI(RT)...
Cancer is the leading cause of deaths in world. A widening disparity cancer burden has emerged between high income and low-middle countries. Closing this divide an ethical imperative but there a dearth data on services from developing This was multi-center, retrospective observational cohort study which enrolled women with breast (BC) attending 8 participating centers Malaysia 2011. All patients were followed up for 12 months diagnosis to determine their access therapies. We assess care...
Renal cell carcinoma (RCC) is a histopathologically and molecularly heterogeneous disease with the chromophobe subtype (chRCC) accounting for approximately 5% of all cases. The median overall survival advanced RCC has improved significantly since advent tyrosine kinase inhibitors mammalian target rapamycin (mTOR) inhibitors. However, high-quality evidence use new generation in patients chRCC lacking. Few published case reports have highlighted temsirolimus chRCC. Here, we report 36-year-old...
Nasopharyngeal carcinoma (NPC) is the commonest radiocurable cancer in Malaysia. This study aimed to determine treatment outcomes and late effects of radiotherapy for NPC patients treated University Malaya Medical Centre (UMMC).All newly diagnosed with referred Oncology unit at UMMC from 2004-2008 were retrospectively analyzed. Treatment 5 years overall survival (OS), disease free (DFS), cause-specific (CSS), loco- regional control (LRC) radiotherapy-related effects. The Kaplan-Meier method...
The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a well recognised paraneoplastic phenomenon and the vast majority are associated with small cell lung carcinoma. Rarely however, non-small variety can sometimes be responsible this report describes such an occurrence. Uniquely in case, after chemotherapy SIADH improved parallel tumour response has not been reported previously.
Abstract Aim To examine the treatment practices for cancer pain relief and adverse event management, factors related to patient outcomes in participating countries/regions. Methods The study was a cross‐sectional survey conducted between September December 2013 10 countries/regions across Asia. Adult patients with history of at least 1 month before entry completed questionnaire. Results A total 1190 were included. mean Box Scale‐11 (BS‐11) score 6.0 (SD 2.1), 86.2% experiencing...