A5026127785- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Chromatin Remodeling and Cancer
- Fibroblast Growth Factor Research
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Health Systems, Economic Evaluations, Quality of Life
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Economic and Financial Impacts of Cancer
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
Instituto de Salud Carlos III
2014-2024
Hospital Universitario Infanta Sofía
2009-2023
Hospital Universitario HM Sanchinarro
2012-2022
Escuela Nacional de Sanidad
2014-2021
Centro Nacional de Microbiologia
2021
HM Hospitales
2014-2020
Ministerio de Ciencia, Innovación y Universidades
2020
Henry Ford Hospital
2017
University of Zurich
2017
Centro Oncológico de Galicia
2012-2016
BackgroundTo date, no immunological data on COVID-19 heterologous vaccination schedules in humans have been reported. We assessed the immunogenicity and reactogenicity of BNT162b2 (Comirnaty, BioNTech, Mainz, Germany) administered as second dose participants primed with ChAdOx1-S (Vaxzevria, AstraZeneca, Oxford, UK).MethodsWe did a phase 2, open-label, randomised, controlled trial adults aged 18–60 years, vaccinated single 8–12 weeks before screening, history SARS-CoV-2 infection....
Tumor-cell-secreted extracellular vesicles (EVs) can cross the disrupted blood-brain barrier (BBB) into bloodstream. However, in certain gliomas, BBB remains intact, which might limit EVs release. To evaluate ability of tumor-derived to BBB, we used an orthotopic xenotransplant mouse model human glioma-cancer stem cells featuring intact BBB. We demonstrated that all types tumor cells-derived EVs-apoptotic bodies, shedding microvesicles and exosomes-cross be detected peripheral blood,...
The aim of this study was to investigate selected proteomic markers the metabolic phenotype breast carcinomas as prognostic cancer progression. For purpose, a series 101 and 13 uninvolved samples were examined for quantitative differences in protein expression mitochondrial glycolytic markers. β-subunit H + -ATP synthase (β-F1-ATPase) heat shock 60 (Hsp60), glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase lactate dehydrogenase identified by immunological techniques. Correlations...
KRAS mutations in colorectal cancer primary tumors predict resistance to anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody therapy patients with metastatic cancer, and thus represent a true indicator of EGFR pathway activation status.KRAS were retrospectively studied using polymerase chain reactions subsequent sequencing codons 12 13 (exon 2) 110 tumors. These studies performed tissue samples from both the tumor their related metastases (93 liver, 84%; 17 lung, 16%). All...
Iron oxide nanoparticles (IONPs) occupy a privileged position among magnetic nanomaterials with potential applications in medicine and biology. They have been widely used preclinical experiments for imaging contrast enhancement, resonance, immunoassays, cell tracking, tissue repair, hyperthermia drug delivery. Despite these promising results, their successful translation into clinical setting is strongly dependent upon physicochemical properties, toxicity functionalization possibilities....
Purpose Bevacizumab regimens are approved for the treatment of recurrent glioblastoma in many countries. Aberrant mesenchymal-epithelial transition factor (MET) expression has been reported and may contribute to bevacizumab resistance. The phase II study GO27819 investigated monovalent MET inhibitor onartuzumab plus (Ona + Bev) versus placebo (Pla glioblastoma. Methods At first recurrence after chemoradiation, bevacizumab-naïve patients with were randomly assigned 1:1 receive Ona (15 mg/kg,...
Extracellular vesicles (EVs) are small membrane-bound which play an important role in cell-to-cell communication. Their molecular cargo analysis is presented as a new source for biomarker detection, and it might provide alternative to traditional solid biopsies. However, the most effective approach EV isolation not yet well established.
FGFR genomic alterations (amplification, mutations, and/or fusions) occur in ∼8% of gliomas, particularly FGFR1 and FGFR3. We conducted a multicenter open-label, single-arm, phase II study selective FGFR1-3 inhibitor, infigratinib (BGJ398), patients with FGFR-altered recurrent gliomas.Adults recurrent/progressive gliomas harboring received oral 125 mg on days 1 to 21 28-day cycles. The primary endpoint was investigator-assessed 6-month progression-free survival (PFS) rate by Response...
Abstract Lung cancer is the top cause of cancer‐related deceases. One reasons development resistance to chemotherapy treatment. In particular, stem cells ( CSC s), can escape treatment and regenerate bulk tumor. this article, we describe a comparison between resistant cisplatin s, both derived from non‐small‐cell lung cell lines H460 A549. Cisplatin‐resistant were obtained after single with drug. s isolated by culture in defined media, under nonadherent conditions. The clonogenic, could be...
One of the major limitations associated with platinum use is resistance that almost invariably develops in different tumor types.In current study, we sought to identify epigenetically regulated microRNAs as novel biomarkers lung and ovarian cancers, ones highest ratios chemo-resistance.Methods: We combined transcriptomic data from microRNA mRNA under influence an epigenetic reactivation treatment a panel four paired cisplatin -sensitive -resistant cell lines, followed by real-time expression...
Obstructive sleep apnoea (OSA) is associated with cancer incidence and mortality. The contribution of the immune system appears to be crucial; however, potential role monocytes natural killer (NK) cells remains unclear. Quantitative reverse transcriptase PCR, flow cytometry in vitro assays were used analyse phenotype response activity 92 patients OSA (60 recently diagnosed untreated 32 after 6 months treatment continuous positive airway pressure (CPAP)) 29 healthy volunteers (HV). We...
Health information grows exponentially (doubling every 5 years), thus generating a sort of inflation science, i.e. the generation more knowledge than we can leverage.In an unprecedented data-driven shift, today doctors have no longer time to keep updated.This fact explains why only one in five medical decisions is based strictly on evidence, which inevitably leads variability.A good solution lies clinical decision support systems, big data analysis.As processing large amounts gains...