A5061307194- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glaucoma and retinal disorders
- HER2/EGFR in Cancer Research
- Respiratory Support and Mechanisms
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Corneal surgery and disorders
- Complementary and Alternative Medicine Studies
- Advanced Proteomics Techniques and Applications
- Glycosylation and Glycoproteins Research
- Neuroendocrine Tumor Research Advances
- Ophthalmology and Eye Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
Kyung Hee University
2016-2025
Chung-Ang University Hospital
2020-2025
Chung-Ang University
2021-2025
Kyung Hee University Medical Center
2017-2023
Kyung Hee University Dental Hospital
2021-2023
Seoul National University Hospital
2023
Seoul National University
2023
Korea University
2005-2019
Weatherford College
2019
ORCID
2019
Epidermal Growth Factor (EGF), a protein pivotal in cell proliferation and survival, has recently shown promise alleviating inflammation. This study investigates EGF's impact on M1 macrophages, exploring its potential for anti-inflammatory anti-vasculogenic interactions with corneal endothelial cells (CECs). Polarized macrophages treated EGF exhibited suppression of gene expressions related to inflammatory vasculogenic signals. The effects were observed co-culture systems human CECs (HCECs),...
Chronic obstructive pulmonary disease (COPD) is one of the major morbidities in public health, and use mHealth technology for rehabilitation patients with COPD can help increase physical activity ameliorate respiratory symptoms.This study aimed to develop a comprehensive management platform improve quality life COPD.The comprised following 2 stages: (1) pilot stage which prototype app was developed; (2) fully-fledged development apps 1 patient monitoring website were developed. We conducted...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are standard of care for patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) common mutations (Del19 or L858R); however, 7%-23% NSCLC tumors harbor uncommon mutations. These highly heterogeneous, and developments in detection techniques helping to identify little no clinical data.
Purpose: We report a case of bilateral nasal and temporal four-site scleromalacia following cosmetic conjunctivectomy, successfully managed with simultaneous restoration surgery at all four sites using autologous tragal perichondrium preserved scleral graft.Case summary: A 56-year-old woman who underwent conjunctivectomy on both eyes 15 years earlier, presented intermittent eye pain. Examination revealed calcium plaques in areas. The most extensive avascular area was the region right eye,...
Background: Non-small cell lung cancer (NSCLC) exhibits low survival rates. Although immune checkpoint inhibitors (ICIs) have become first-line treatment for NSCLC, their limited response to ICI monotherapy has led exploration of combination treatments. However, the high incidence treatment-related adverse events associated with conventional drug combinations highlighted need alternative herbal therapy. Bojungikki-tang (BJIKT), a traditional medicine, been used treat gastrointestinal...
To evaluate the incidence and risk of drug-induced interstitial lung disease (DIILD) associated with anti-neoplastic drugs among patients cancer in Korea. This nested case-control study included 457,685 diagnosed treated from a retrospective nationwide population-based cohort between 2017 2021. The rate DIILD risks by drug categories were analyzed. Among 270,595 patients, 2,634 developed ILD, resulting an 4.12 per 1,000 person-years (95% confidence interval (CI): 3.97-4.28). was more...
To analyze anterior, posterior, and total corneal refractive profiles thickness using anterior segment swept-source optical coherence tomography (AS SS-OCT) in Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) patients. This retrospective study compared 23 eyes from 14 SJS/TEN patients (Group 2) with age- sex-matched controls 1). AS SS-OCT measured pachymetry. Parameters included power (TCP) values, posterior-to-anterior curvature ratio (P/A ratio), maximal (Kmax), profiles....
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. has intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through signaling cascade airway epithelium. We have investigated effects inhibitor, gefitinib, on ovalbumin (OVA)-induced, allergic inflammation epithelia mice. OVA-sensitized mice were pretreated with gefitinib at two different doses (12.5 50 mg/kg) then challenged OVA. OVA challenge increased total count...
Purpose Lung cancer is among the most common cancers. Bronchoalveolar lavage fluid (BALF) can be easily obtained from patients with lung The aim to develop a novel proteomic method of molecule‐based sensitive detection biomarkers BALF. Experimental Design BALF samples are collected segmental bronchus 14 cancers Kyung Hee University Hospital. First, proteome depleted using depletion column, and then peptides prepared enriched low abundant proteins fractionated by high pH reverse phase liquid...
Hyaluronic acid (HA) is widely used in medicine, especially for contouring or volumizing soft tissue and intra-articular injection. However, it not well known that HA injection can cause life-threatening pulmonary complications. We recently experienced a case of woman who was diagnosed with diffuse alveolar hemorrhage (DAH) after receiving an illegal vaginal filler A 54-year-old female visited our clinic complaining hemoptysis dyspnea. Chest computed tomographic (CT) scan showed ground glass...
Although programmed death-ligand 1 (PD-L1) expression is widely accepted as a predictive and prognostic biomarker in immunotherapy, its implications lung cancer patients with driving mutations are still unclear. The objective of this study to determine the association between PD-L1 treatment outcome epidermal growth factor receptor (EGFR)-mutated treated tyrosine kinase inhibitors (TKIs).We retrospectively enrolled EGFR-mutant, advanced adenocarcinoma who received first-line EGFR-TKIs...
Real-time digital image processing to optimally enhance low vision is now realizable with recent advances in personal computers. This study aimed evaluate the efficacy of a wearable smartphone-based aid (LVA) customizable enhancement patients visual impairment. We recruited 35 subjects impairment and who were literate cognitively capable. The completed training session provided LVA for 4-week use. Visual functions including binocular best-corrected distance, intermediate, near acuities;...
Small cell lung cancer (SCLC) is one of the malignant cancers with aggressive progression and poor prognosis. Bronchoalveolar lavage fluid (BALF) has been arising recently as a potential source biomarkers for cancers. In this study, we performed quantitative BALF proteomic analysis to identify SCLC.BALF were collected from tumor-bearing lungs non-tumor five SCLC patients. Then, proteomes prepared TMT-based mass spectrometry analysis. Differentially expressed proteins (DEP) identified when...
Adenovirus is a common pathogen of acute upper respiratory infection in children and generally self-limiting. Severe adenovirus infections have been reported immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. pneumonia immunocompetent has rarely optimal treatment not established. We report case community-acquired severe which was successfully treated with early administration oral ribavirin.A 39 year-old, previously healthy Korean male...
Abstract The aim of the study was to investigate prognostic significance advanced lung cancer inflammation index (ALI) in patients with limited-stage small-cell (LS-SCLC) undergoing definite chemo-radiotherapy (CRT). We included 87 LS-SCLC from South Korea, treated between 2005 and 2019 CRT. ALI calculated using body mass index, serum albumin, neutrophil–lymphocyte ratio. categorized 38 into high group (ALI ≥ 44.3) 48 low < 44.3). Patients exhibited longer overall survival (OS) than...