A5089362581- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Lung Cancer Treatments and Mutations
- Sepsis Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Long-Term Effects of COVID-19
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Medical Imaging and Pathology Studies
- Antifungal resistance and susceptibility
- Diagnosis and treatment of tuberculosis
- Systemic Sclerosis and Related Diseases
Hanyang University
2015-2024
Anyang University
2020-2024
Hanyang University Medical Center
2022-2024
Hanyang University Seoul Hospital
2003-2020
Yeungnam University
2006-2014
Yeungnam University College
2013
Korea University
2011-2012
Korea University Medical Center
2008-2012
Hanyang University Guri Hospital
2011
Yeungnam University Medical Center
2011
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abnormal growth of fibroblasts scarring. While the pathogenesis IPF not clearly understood, activation transforming factor-β (TGF-β) disruption alveolar basement membrane seem to play important roles in leading excess matrix, which associated with activated matrix metalloproteinase (MMP) aberrant proliferation myofibroblasts. The Wnt/β-catenin pathway an regulator cellular differentiation signal...
Background There are limited data regarding the relationship between interstitial lung disease (ILD) and natural course of COVID-19. In this study, we investigate whether patients with ILD more susceptible to COVID-19 than those without evaluate impact on severity in Methods A nationwide cohort (n=8070) a 1:15 age-, sex- residential area-matched (n=121 050) were constructed 1 January 2020 30 May Korea. We performed nested case–control study compare proportions matched cohort. Using cohort,...
Chronic systemic corticosteroid (CS) therapy is associated with an increased risk of mortality in patients many chronic diseases. However, it has not been elucidated whether CS asthma. The aim this study was to determine the effects on long-term adult asthma.A population-based matched cohort males and females aged ≥18 years asthma performed using Korean National Health Insurance Service database from 2005 2015. Hazard ratio (HR) 95% confidence interval for all-cause among CS-dependent (CS...
BackgroundPrevious studies have suggested that respiratory virus infections may be associated with new-onset asthma. However, whether coronavirus disease 2019 (COVID-19) is an increased risk of asthma remains unclear.ObjectiveWe aimed to evaluate recent COVID-19 increases the and vaccination could mitigate this risk.MethodsWe constructed 3 different study designs using Korean National Health Insurance claim-based database: 1: COVID-19–diagnosed subjects (COVID-19 cohort) their matched...
Objectives Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung (ILD) after COVID-19 is unclear. We aimed determine whether increases risk ILD and vaccination against can reduce this risk. Methods This retrospective cohort study used data from Korean National Health Insurance claim-based database. Two groups propensity score (PS)-matched control were constructed: Study 1: participants with...
Introduction Studies that comprehensively evaluate the association between physical activity (PA) levels, particularly by quantifying PA intensity, and healthcare use requiring emergency department (ED) visit or hospitalisation in patients with chronic obstructive pulmonary disease (COPD) are limited Korea. Methods The risk of all-cause respiratory ED according to presence absence COPD level was evaluated a retrospective nationwide cohort comprising 3308 subjects (COPD cohort) 293 358...
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with fixed airflow limitation. The mechanisms underlying airway are poorly understood, and no therapeutic option available. Wnt/β-catenin signaling pathway involved various physiological pathological processes, including fibrosis smooth muscle hypertrophy. In this study, we investigated the roles asthma. Wnt7a mRNA expression was prominent induced sputum from asthma compared that healthy controls. Next,...
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than those without bronchiectasis. Using 2005–2015 from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause cohort relative to matched cohort. The effect of comorbidities over study period on was also assessed. All-cause significantly (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality...
Response to vaccines generally varies according individual factors of the vaccinated subjects such as demographics and immune status. While there are various reports associated with immunogenicity mRNA COVID-19 vaccines, little is known about those adenovirus vector vaccines. We conducted a prospective observational study assess relationships antibody level age, sex, body mass index (BMI), adverse reactions (ARs) an vaccine, ChAdOx1 nCoV-19. Healthcare workers who planned receive both first...
When assessing long-term tuberculosis (TB) mortality, few studies addressed the impact of behavior habits and socioeconomic status. Therefore, we aimed to evaluate TB mortality risk factors while accounting for potential confounders.This cohort study included survivors (n = 82 098) aged ≥20 years between 2010 2017, 1:1 age- sex-matched controls 098). The participants were followed up death 1 year after enrollment until December 2018. Long-term was adjusted (smoking, alcohol consumption, or...
Rationale: It remains unclear whether non-cystic fibrosis bronchiectasis increases the risk of lung cancer, because smoking history was not considered in previous studies. Objectives: To evaluate participants with have a higher incident cancer than those without information on status. Methods: This population-based cohort study 3,858,422 individuals who participated 2009 National Health Screening Program. We evaluated incidence (n = 65,305) and 3,793,117). followed up until date diagnosis,...
The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare risk individuals with those without using a nationwide longitudinal dataset.Using Korean National Health Insurance Service dataset 2010 2017, we identified 4845 aged ≥ 20 years 24,225 who were matched 1:5 by age sex. They followed up until date diagnosis, death, or December 31, 2019, whichever came first.During median follow-up period 6.0 (interquartile range, 3.2-8.7)...
Bronchiectasis is one of the common chronic respiratory diseases and associated with morbidity mortality. However, neither its prevalence nor etiology well-defined. We aimed to estimate risk factors bronchiectasis in adults. In a retrospective study, we analyzed radiologic findings on chest computed tomography (CT) images performed as part health-screening program. From January December 2008, 1,409 (24.6%) 5,727 participants screening program health promotion center at university hospital...
Background: Long-term corticosteroid (CS) use is associated with increased mortality in patients asthma, and comorbid bronchiectasis also frequent asthma exacerbation healthcare use. However, there limited information on whether further increases CS-dependent asthma. This study examined the impact of Methods: A retrospective cohort ⩾18 years old was established using records from Korean National Health Insurance Service database 2005 to 2015. Patients without were matched by age, sex, type...
There are conflicting results regarding endogenous estrogen exposure and risk of incident nontuberculous mycobacterial pulmonary disease (NTM-PD). In addition, evidence on impact hormone replacement therapy (HRT) NTM-PD is lacking. This study aimed to evaluate the impacts HRT in postmenopausal women.This population-based cohort comprised 1 400 095 women without previous who participated 2009 national health screening exam South Korea. The was followed until date NTM-PD, death, or December...
The aim of this study is to examine the impact tumor necrosis factor inhibitors (TNFI) on nontuberculous mycobacterium (NTM) infection in rheumatoid arthritis (RA) patients a tuberculosis (MTB) endemic area. We selected 1089 TNFI-treated RA and 4356 untreated using propensity-matching analysis according age, gender, Charlson comorbidity index Korean National Health Insurance Service database from July 2009 December 2010. Both groups were followed-up until end 2016 measure incidence...
Measurement of the fraction nitric oxide (FeNO) in exhaled air is useful management asthma. A new hand-held (NO) analyzer, NIOX MINO, simple and easy to use clinical practice. In this study, FeNO values measured using MINO were compared with those obtained a stationary chemiluminescence Sievers NOA280i.FeNO was 100 adults, both NOA280i. Nine (9.0%) these subjects had The first acceptable measurement mean two measurements NOA280i compared.There significant correlation between concentrations...