Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abnormal growth of fibroblasts scarring. While the pathogenesis IPF not clearly understood, activation transforming factor-β (TGF-β) disruption alveolar basement membrane seem to play important roles in leading excess matrix, which associated with activated matrix metalloproteinase (MMP) aberrant proliferation myofibroblasts. The Wnt/β-catenin pathway an regulator cellular differentiation signal...

Airway remodeling is a key characteristic of chronic asthma, particularly in patients with fixed airflow limitation. The mechanisms underlying airway are poorly understood, and no therapeutic option available. Wnt/β-catenin signaling pathway involved various physiological pathological processes, including fibrosis smooth muscle hypertrophy. In this study, we investigated the roles asthma. Wnt7a mRNA expression was prominent induced sputum from asthma compared that healthy controls. Next,...

Bronchiectasis is one of the common chronic respiratory diseases and associated with morbidity mortality. However, neither its prevalence nor etiology well-defined. We aimed to estimate risk factors bronchiectasis in adults. In a retrospective study, we analyzed radiologic findings on chest computed tomography (CT) images performed as part health-screening program. From January December 2008, 1,409 (24.6%) 5,727 participants screening program health promotion center at university hospital...

Abstract The role of protein kinase C (PKC) in the induction nitric oxide (NO) synthesis murine peritoneal macrophages was examined. Phorbol ester, a PKC activator, had no effect on NO by itself, whereas IFN-gamma alone modest activity. When phorbol ester used combination with IFN-gamma, there marked cooperative dose-dependent manner. This increase reflected as increased amount inducible synthase (iNOS) mRNA, determined Northern blotting. optimal shown at 6 h after treatment IFN-gamma. also...

Background. While initial education and regular evaluation of inhaler technique in patients are emphasized the management asthma chronic obstructive pulmonary disease, health care professionals not experienced using inhalers. This study assessed whether internal medicine residents used common inhalers correctly a single teaching session successfully improved their performance. Methods. We evaluated 142 from six university hospitals Korea for techniques with three different devices: metered...

Measurement of the fraction nitric oxide (FeNO) in exhaled air is useful management asthma. A new hand-held (NO) analyzer, NIOX MINO, simple and easy to use clinical practice. In this study, FeNO values measured using MINO were compared with those obtained a stationary chemiluminescence Sievers NOA280i.FeNO was 100 adults, both NOA280i. Nine (9.0%) these subjects had The first acceptable measurement mean two measurements NOA280i compared.There significant correlation between concentrations...

Abstract The degradation of polystyrene (PS) in sub‐ or supercritical water was carried out at reaction temperatures ranging from 370°C to 420°C and pressures 240 320 bar. At 370°C, where is a subcritical state, the equilibrium about 5 min, whereas 380°C 390°C, it completed 15 3 respectively. conversion state (100 wt %) higher than that (ca. 80 %). dependence on time selectivity for products—styrene monomer, styrene dimer, trimer, toluene, ethyl benzene, isopropyl triphenyl benzene—were...

Exacerbations of chronic obstructive pulmonary disease (COPD) lead to high morbidity and mortality. Respiratory virus infection is considered as one the important causes COPD exacerbations. The aim this study was assess prevalence respiratory in exacerbations find factors associated with susceptibility viral infections. Furthermore, we tried examine if caused by infections have more severe clinical outcomes comparison those non-viral causes. We enrolled patients acute who were hospitalized a...

Background/Aims Smoking is widely acknowledged as the single most important risk factor for chronic obstructive pulmonary disease (COPD). However, of COPD in nonsmokers exposed to secondhand smoke remains controversial. In this study, we investigated association exposure with prevalence who reported never smoking. Methods This study was based on data obtained from Korean National Health and Nutrition Examination Surveys (KNHANES) conducted 2008 2010. Using nationwide stratified random...

The rapid response system (RRS) is an innovative designed for in-hospital, at-risk patients but underutilization of the RRS generally results in unexpected cardiopulmonary arrests. We implemented extended (E-RRS) that was triggered by actively screening prior to calls from primary medical attendants. These were identified laboratory data, emergency consults, and step-down units. A four-member team assembled included ICU staff, visited more than twice per day evaluation, triage, treatment...

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to the active cortisol. 11β-HSD1 may be involved in resolution of inflammation. In present study, we investigate anti-inflammatory effects 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344), a selective inhibitor, lipopolysaccharide (LPS)-activated C57BL/6J mice and macrophages. LPS increased activity expression macrophages, which was inhibited by KR-66344. addition, KR-66344...

Pigtail catheter drainage is a common procedure for the treatment of pleural effusion and pneumothorax. The most complications pigtail insertion are pneumothorax, hemorrhage chest pains. Cerebral air embolism rare, but often fatal. In this paper, we report case cerebral in association with effusion. A 67-year-old man being presented dyspnea, cough right-side pains was administered antibiotics pneumonia. pneumonia failed to resolve loculated parapneumonic developed. inserted order drain...

Objectives: We report a case of death due to asthma attack in plastic injection process worker with history asthma.Methods: To assess task relevance, personal including occupational and medical records were reviewed.Samples the substances utilized collected by visiting patient's workplace.The work environment actual was reproduced laboratory, released evaluated.Results: The confirmed that conventional remission.The analysis resins discharged from simulation revealed styrene, which causes...

Invasive pulmonary aspergillosis (IPA) is rarely reported in patients who have normal immune function. Recently, IPA risk was nonimmunocompromised hosts, such as with chronic obstructive disease and critically ill intensive care units. Moreover, influenza infection also believed to be associated among immunocompetent patients. However, most reports on A infection, including pandemic H1N1, B were scarcely reported. Here, we report probable a fatal clinical course an patient infection. We...

Whether indoor painting aggravates preexisting allergic diseases remains unclear. We aimed to evaluate the impact of new classroom on aggravation asthma, rhinitis (AR), and atopic dermatitis (AD) in children. Studied school was previously painted with conventional water-based paint 20 years ago had natural ventilation system. identified a total 172 children aged 10-12 17 classrooms, which were allocated newly rooms low-volatile organic compounds (VOC), paint, or existing rooms. After...

Gastric mucosal damage by iron pills is often reported. However, pill aspiration uncommon. Oxidation of the impacted causes bronchial that progresses to chronic inflammation, necrosis, endobronchial stenosis and rarely, perforation. We reported a case 92-year-old woman with productive cough significant left-sided atelectasis. Bronchoscopy revealed substantial luminal narrowing exudative inflammation left main bronchus. Bronchial washing cytology showed necroinflammatory exudate small amount...

EPHB2 is a member of the Eph receptor tyrosine kinase family and direct transcriptional target β‐catenin/TCF. plays an important role in maintaining correct positioning proliferative compartment crypt‐villous axis. A loss expression has been observed human tumors, particularly colonic adenomas carcinomas. search was made for mutations at A9 tract exon 17, allelic gene locus, promoter hypermethylation 81 sporadic gastric cancers order to determine if genetic or epigenetic alterations are...

Congenital cystic adenomatoid malformation (CCAM) is an uncommon, nonhereditary anomaly caused by arrest of lung. Patients with CCAM may present respiratory distress as newborns, or remain asymptomatic until later in life. type I rarely found association bronchial atresia (BA) adults; we such a case.A 54-year-old female presented chronic cough and blood-tinged sputum. Physical examination laboratory tests were unremarkable. Chest radiographs CT scan the chest showed multiple large air-filled...

Inhibition of angiogenesis is considered a promising therapeutic approach for cancer treatment. Our previous genetic research showed that the use cell-penetrating peptide to inhibit pleckstrin homology (PH) domain 3-phosphoinositide-dependent kinase 1 (PDK1) was viable suppress pathological angiogenesis. Herein, we synthesized and characterized novel small molecule, CU05-1189, based on our prior study present evidence first time this compound possesses antiangiogenic properties both in vitro...

Background In uncontrolled hemoptysis patient, bronchial arteriography and artery embolization (BAE) is a important procedure in diagnosis treatment. The aim of this study to assess the incidence contrast-induced nephropathy risk factors (CIN) after BAE. Methods We retrospectively reviewed medical records patients who underwent BAE two university hospitals from January 2003 December 2011. CIN was defined as rise serum creatinine more than 25% baseline value or 0.5 mg/dL at between 48 hours...

Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration nitric oxide in nasal cavity air (nNO) influenced by allergic rhinitis and/or sinusitis, both which are causes UACS. We measured nNO levels patients with UACS and those other causes. also examined usefulness measuring for differentiating sinusitis from sinusitis. study included 93 adult lasting more than threeweeks....