A5048322657- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Respiratory Support and Mechanisms
- Thermoregulation and physiological responses
- Trauma and Emergency Care Studies
- Airway Management and Intubation Techniques
- Traumatic Brain Injury Research
- Photoacoustic and Ultrasonic Imaging
- Climate Change and Health Impacts
- Anesthesia and Neurotoxicity Research
- Allergic Rhinitis and Sensitization
- Cardiovascular Health and Disease Prevention
- Pericarditis and Cardiac Tamponade
- Mechanical Circulatory Support Devices
- Ocular Surface and Contact Lens
- Nicotinic Acetylcholine Receptors Study
- Disaster Response and Management
- Neonatal and fetal brain pathology
Dong-A University Hospital
2010-2025
Neurological Surgery
2018-2023
Hospital de Clínicas de Porto Alegre
2021
Boston University
2021
Grady Memorial Hospital
2021
Boston Medical Center
2021
Universidade Federal do Rio Grande do Sul
2021
Sound Shore Medical Center
2020
Dong-A University
2011-2019
Soonchunhyang University
2014-2018
<b>Background: </b> Intracranial hemorrhage is a serious possible complication in patients with brain arteriovenous malformation (AVM). Several morphologic factors associated hemorrhagic AVM presentation have been established, but their relevance for the risk of subsequent remains unclear. <b>Methods: The authors analyzed follow-up data on 622 consecutive from prospective Columbia database, limited to period between initial diagnosis and start treatment (i.e., any endovascular, surgical, or...
The morbidity from spontaneous hemorrhage of untreated brain arteriovenous malformations (AVM) is not well described.The 241 consecutive AVM patients (mean age 37+/-16 years, 52% women) the prospective Columbia Databank initially presenting with were evaluated using Rankin Scale (RS) and National Institute Health Stroke (NIHSS). From patients, 29 (12%) had subsequent intracranial during follow-up. For further comparisons, 84 non-AVM intracerebral Northern Manhattan Study (NOMAS) served as a...
Endovascular brain cooling as a method for rapid and selective induction of hypothermic neuroprotection has not been systematically studied in humans. In this clinical pilot study we investigated the feasibility, safety, physiologic responses short-term with IC-CSI.We 18 patients (50 +/- 10 years old, 9 women) undergoing follow-up cerebral angiography after previous treatment vascular malformations. Isotonic saline (4-17 degrees C) was infused into 1 internal carotid artery at 33 mL/min...
To evaluate the pharmacokinetic characteristics of 2-mg and 4-mg nicotine polacrilex lozenges, following four separate studies were conducted in healthy adult smokers: (a) A single-dose, four-way crossover (replicate design) study to compare lozenge gum, (b) a two-way (c) multiple-dose, lozenges administered every 90 min gums 60 at 2- dose levels, (d) three-way profiles when three different ways: (i) Used as directed, (ii) chewed immediately swallowed, (iii) chewed, retained mouth for 5 min,...
Background and PurposezzThere is little information available about the effects of Emergency Medical Service (EMS) hospital notification on transfer intrahospital processing times in cases acute ischemic stroke.MethodszzThis study retrospectively investigated real imaging for suspected stroke (AS) with EMS a requirement intravenous (IV) tissue-type plasminogen activator (t-PA) without notification.Also we compared intra-hospital receiving t-PA between patients prehospital...
Antiplatelet therapy, where regimens are tailored based on platelet function testing, has been introduced into neurointerventional surgery. This nationwide registry study evaluated the effect and safety of antiplatelet therapy in stent assisted coiling for unruptured aneurysms compared with conventional using a standard regimen.This enrolled 1686 patients 44 participating centers who received between January 1, 2019 December 31, 2019. The regimen (aspirin clopidogrel) was used all group...
Background and Purpose— To assess the outcome in acute ischemic stroke patients not eligible for systemic thrombolysis (outside 3-hour time window, after surgery, or on anticoagulant) undergoing endovascular recanalization therapy (ERT) at Columbia University Medical Center (CUMC) to determine US nationwide usage of ERT stroke. Methods— Patients treated CUMC from 2001 2004 Nationwide Inpatient Sample (NIS) comprising 20% all admissions United States 1999 2002 were analyzed retrospectively....
To determine the effect of brain lesion pattern on early recovery after severe traumatic injury (TBI).In a setting multimodal rehabilitation unit at level I trauma center, 135 consecutive survivors TBI (mean age, 40 years, 25% women) were studied prospectively. Assessment disability was performed weekly using an extended Barthel Index (eBI) ranging from -325 to +100 points. Clinical and morphologic variables tested in multivariate logistic regression models predictors outcome.Imaging...
Cerebral autoregulation (CA) enables the brain to maintain stable cerebral blood flow (CBF). CA can be assessed noninvasively by determining correlations between CBF velocity (CBFV) and spontaneous changes in pressure. Postrecording signal analysis methods have included both frequency- time-domain methods. However, test-retest reliability, cross-validation, determination of normal values not been adequately established.In 53 healthy volunteers, a transfer function was applied calculate phase...
The feasibility of rapid cerebral hypothermia induction in humans with intracarotid cold saline infusion (ICSI) was investigated using a hybrid approach jugular venous bulb temperature (JVBT) sampling and mathematical modeling transient steady state brain distribution. This study utilized both forward modeling, which temperatures were predicted based on input temperatures, inverse where inferred JVBT. Changes ipsilateral anterior circulation territory (IACT) estimated eight patients as...
Several
<i>Background:</i> We aimed to identify the rate of major neurologic improvement (MNI) at 24 h following endovascular recanalization therapy (ERT) for acute ischemic stroke and its association with short-term outcome. <i>Methods:</i> retrospectively reviewed consecutive patients presenting our institution over 4 years undergoing ERT. Angiograms were independently reviewed. Data on demographics, medical history, initial NIHSS score, 24-hour site vascular lesion, pre-...